Reversible therapeutic resistance in mutant lung cancer caused by loss induced lineage plasticity.

Treatment with EGFR tyrosine kinase inhibitors (EGFR TKI) is standard of care for patients with lung cancer initiated by activating mutations in the gene. While EGFR TKI treatment is effective, virtually all patients progress on therapy. Loss of function mutations in the tumor suppressor gene are associated with poor EGFR TKI outcomes, but underlying mechanisms remain unclear.

Dengue disease detection via a minimal area 2D photonic crystal nanocavity-based refractive index optical biosensor: numerical analysis.

Despite advancements in optical biosensing technologies, existing methods for detecting dengue-infected blood components often lack the sensitivity and precision required for early diagnosis, emphasizing the necessity of better sensor designs. A compact photonic crystal nanocavity-based optical sensor has been designed to detect dengue-infected blood components. The simulation is performed using the finite-difference time-domain numerical technique with a Gaussian source.

Optimization of steel anchor pile configurations for enhanced pullout resistance in expansive soil foundations.

This study aims to predict the pullout behavior of steel anchor piles in saturated expansive soil using finite element method-based PLAXIS 3D CONNECT Edition V22 software. It inspects the effects of varying pile parameters and spacings for a displacement of 10% of the pile diameter. The study evaluates the performance of single and group anchor piles by comparing square configurations (2 × 2, 3 × 3, and 4 × 4) at varying centre-to-centre (c/c) spacings of 2.

Sustainable subgrade improvement with calcium carbide residue and rice husk ash.

Expansive soils, particularly black cotton soil (BCS), present significant engineering challenges due to their high swelling potential and shrinkage behavior, leading to structural instability. This study evaluates the stabilization potential of calcium carbide residue (CCR) and rice husk ash (RHA) by assessing their combined effects on the geotechnical properties of BCS. Laboratory tests, including differential free swell (DFS), compaction, unconfined compressive strength (UCS), and California bearing ratio (CBR), were conducted to determine the optimal mix proportions.

Correction: Artificial neural network, machine learning modelling of compressive strength of recycled coarse aggregate based self-compacting concrete.

[This corrects the article DOI: 10.1371/journal.pone.

Multi-dimensional scaling for space-time transformation to achieve sustainable planning and management of water resource under changing land use pattern.

The land use transition plays an important role for terrestrial environmental services, which had a mixed impact of positive and negative on the groundwater and terrestrial water resource. The health of ecological systems and groundwater depends on the mapping and management of land use. The Ganga basin is one of the most densely populated and agriculture-intensive river systems in the South Asia and the world.

Surface-engineered vertically-aligned ZnO nanorod for sensitive non-enzymatic electrochemical monitoring of cholesterol.

Developing highly sensitive and selective non-enzymatic electrochemical biosensors for disease biomarker detection has become challenging in healthcare applications. However, advances in material science are opening new avenues for creating more dependable biosensing technologies. In this context, the present work introduces a novel approach by engineering a hybrid structure of zinc oxide nanorod (ZnO NR) modified with iron oxide nanoparticle (FeO NP) on an FTO electrode.

A grain-like cerium oxide nanostructure: synthesis and uric acid sensing application.

Utilizing nanomaterials on the working electrode of sensors enables the fabrication of highly sensitive devices for the detection of various analytes. Herein, a facile synthesis method is used to formulate a grain-like cerium oxide (CeO) nanostructure. The structural features and surface properties of the synthesized CeO nanostructure were studied, which showed that the CeO nanostructure exhibited grain-like morphology, good crystalline structure, and excellent vibrational properties.

A practical approach to demonstrate the circular economy in remediation of textile dyes using nutraceutical industrial spent.

We used Nutraceutical Industrial Coriander Seed Spent (NICSS), a readily available, cheap, eco-friendly, and ready-to-use material, as an innovative adsorbent for the bioremediation of a bisazo Acid Red 119 (AR 119) dye, which is likely a mutagen from textile industrial effluents (TIE). A laboratory-scale experiment was tailored to demonstrate the framework of the circular economy (CE) in the remediation of textile dyes using Nutraceutical Industrial Spent to align with the principles of sustainability and valorization. An experimental value of 97.

Artificial neural network, machine learning modelling of compressive strength of recycled coarse aggregate based self-compacting concrete.

This research study aims to understand the application of Artificial Neural Networks (ANNs) to forecast the Self-Compacting Recycled Coarse Aggregate Concrete (SCRCAC) compressive strength. From different literature, 602 available data sets from SCRCAC mix designs are collected, and the data are rearranged, reconstructed, trained and tested for the ANN model development. The models were established using seven input variables: the mass of cementitious content, water, natural coarse aggregate content, natural fine aggregate content, recycled coarse aggregate content, chemical admixture and mineral admixture used in the SCRCAC mix designs.

An Electroanalytical Enzymeless α-FeO-ZnO Hybrid Nanostructure-Based Sensor for Sensitive Quantification of Nitrite Ions.

Nitrite monitoring serves as a fundamental practice for protecting public health, preserving environmental quality, ensuring food safety, maintaining industrial safety standards, and optimizing agricultural practices. Although many nitrite sensing methods have been recently developed, the quantification of nitrite remains challenging due to sensitivity and selectivity limitations. In this context, we present the fabrication of enzymeless iron oxide nanoparticle-modified zinc oxide nanorod (α-FeO-ZnO NR) hybrid nanostructure-based nitrite sensor fabrication.

Superior haplotypes towards the development of blast and bacterial blight-resistant rice.

Rice blast and bacterial leaf blight, are major disease, significantly threatens rice yield in all rice growing regions under favorable conditions and identification of resistance genes and their superior haplotypes is a potential strategy for effectively managing and controlling this devastating disease. In this study, we conducted a genome-wide association study (GWAS) using a diverse set of 147 rice accessions for blast and bacterial blight diseases in replications. Results revealed 23 (9 for blast and 14 for BLB) significant marker-trait associations (MTAs) that corresponded to 107 and 210 candidate genes for blast and BLB, respectively.

SpeedFlower: a comprehensive speed breeding protocol for indica and japonica rice.

To increase rice yields and feed billions of people, it is essential to enhance genetic gains. However, the development of new varieties is hindered by longer generation times and seasonal constraints. To address these limitations, a speed breeding facility has been established and a robust speed breeding protocol, SpeedFlower is developed that allows growing 4-5 generations of indica and/or japonica rice in a year.

Decision Tree-Based Modeling of the Aeration Effectiveness of Circular Plunging Jets.

Since soft computing has gained a lot of attention in hydrological studies, this study focuses on predicting aeration efficiency () using circular plunging jets employing soft computing techniques such as reduced error pruning tree (REPTree), random forest (RF), and M5P. The study undertaken required the development and validation of models, which were achieved using 63 experimental data values with input variables, such as angle of inclination of tilt channel (α), number of plunging jets (), discharge of each jet (), hydraulic radius of each jet (HR), and Froude number (Fr. No), to evaluate the aeration efficiency (), which served as the output variable.

Investigating the Flexural Behavior of a Two-Span High-Performance Concrete Beam Using Experimentally Derived Stress Block Parameters.

High-performance concrete (HPC) is increasingly used in construction due to its superior strength and durability. However, current stress block parameters used for designing normal-strength concrete cannot be safely applied to HPC. To address this issue, new stress block parameters have been proposed through experimental works, which are used for designing HPC members.

Mechanical Properties of High-Strength Self-Compacting Concrete.

In this research work, the mechanical properties of high-strength self-compacting concrete (HSSCC) were studied. Three mixes were selected, having compressive strengths of more than 70, 80, and 90 MPa, respectively. For these three mixes, the stress-strain characteristics were studied by casting cylinders.

Al2014-Alumina Aerospace Composites: Particle Size Impacts on Microstructure, Mechanical, Fractography, and Wear Characteristics.

An Al2014-alumina (AlO) composite's characteristics are significantly influenced by the reinforcement particle size variation. Therefore, this study examines the microstructure, mechanical, fractography, and wear performance of an Al2014-AlO composite made using a unique two-stage stir casting method and various alumina weight fractions (9, 12, and 15 wt %). Three categories of alumina particle size are used, i.

Highly Sensitive Electrochemical Non-Enzymatic Uric Acid Sensor Based on Cobalt Oxide Puffy Balls-like Nanostructure.

Early-stage uric acid (UA) abnormality detection is crucial for a healthy human. With the evolution of nanoscience, metal oxide nanostructure-based sensors have become a potential candidate for health monitoring due to their low-cost, easy-to-handle, and portability. Herein, we demonstrate the synthesis of puffy balls-like cobalt oxide nanostructure using a hydrothermal method and utilize them to modify the working electrode for non-enzymatic electrochemical sensor fabrication.

Resolution of conflict of reduced sludge production with EBPR by coupling OSA to A/O process in a pilot scale SBR.

The pinnacle of all the efforts of nutrient removal is practically put-down the moment biological cells are lysed, hydrolyzed or digested causing subsequent reappearance of assimilated nitrogen and phosphorus in any biological process. While sludge reduction requires high SRT, the enhanced phosphorus assimilative uptake demands low SRT. A novel reactor configuration for enhanced sludge and phosphorus removal was put to test by incorporating a side stream anaerobic reactor to an Anaerobic-Anoxic-Aerobic (AO) SBR with a pre-anoxic chamber and an influent receiving inlet anaerobic reactor.

Electrochemical Ultrasensitive Sensing of Uric Acid on Non-Enzymatic Porous Cobalt Oxide Nanosheets-Based Sensor.

Transition metal oxide (TMO)-based nanomaterials are effectively utilized to fabricate clinically useful ultra-sensitive sensors. Different nanostructured nanomaterials of TMO have attracted a lot of interest from researchers for diverse applications. Herein, we utilized a hydrothermal method to develop porous nanosheets of cobalt oxide.

Regulation of Cyclin D1 Degradation by Ubiquitin-Specific Protease 27X Is Critical for Cancer Cell Proliferation and Tumor Growth.

Unlabelled: Cyclin D1 (CCND1) is a critical regulator of cell proliferation and its overexpression has been linked to the development and progression of several malignancies. CCND1 overexpression is recognized as a major mechanism of therapy resistance in several cancers; tumors that rely on CCND1 overexpression to evade cancer therapy are extremely sensitive to its ablation. Therefore, targeting CCND1 is a promising strategy for preventing tumor progression and combating therapy resistance in cancer patients.

A Comparative Study of Platelet-Rich Fibrin and Platelet-Rich Fibrin with Hydroxyapatite to Promote Healing of Impacted Mandibular Third Molar Socket.

Aim: The purpose of this study was to compare the efficacy of platelet-rich fibrin (PRF) and platelet-rich fibrin (PRF) with hydroxyapatite (HA) on postoperative pain, swelling, soft tissue healing and osseous regeneration in mandibular third molar extraction socket in human patient.

Materials And Methods: This prospective study included total 40 patients who reported to the Department of Oral and Maxillofacial Surgery (OMFS), Teerthanker Mahaveer Dental College and Research Centre (TMDC&RC), Moradabad (U.P.

Vertically Oriented Zinc Oxide Nanorod-Based Electrolyte-Gated Field-Effect Transistor for High-Performance Glucose Sensing.

Nanomaterial-based biosensors are a promising fit for portable and field-deployable diagnosis sensor devices due to their mass production, miniaturization, and integration capabilities. However, the fabrication of highly stable and reproducible biosensor devices is challenging. In this work, we grow a vertically oriented architecture of zinc oxide nanorods onto the active working area (i.

Development of Eco-Friendly Concrete Mix Using Recycled Aggregates: Structural Performance and Pore Feature Study Using Image Analysis.

The shortage of natural aggregates has compelled the developers to devote their efforts to finding alternative aggregates. On the other hand, demolition waste from old constructions creates huge land acquisition problems and environmental pollution. Both these problems can be solved by recycling waste materials.

New sheriff in town: Cyclic peptide inhibitors of a DUB module.

In this issue of Cell Chemical Biology, Morgan et al. (2021) show that cyclic peptides can be potent and highly specific inhibitors for deubiquitinating enzymes. This study identifies the first selective inhibitors of the cancer-associated ubiquitin-specific protease 22 (USP22).