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High-performance concrete (HPC) is increasingly used in construction due to its superior strength and durability. However, current stress block parameters used for designing normal-strength concrete cannot be safely applied to HPC. To address this issue, new stress block parameters have been proposed through experimental works, which are used for designing HPC members. In this study, the behavior of HPC was investigated using these stress block parameters. Two-span beams made of HPC were tested under five-point bending, and an idealized stress block curve was derived from the experimental stress-strain curve for grades 60, 80, and 100 MPa. Based on the stress block curve, equations for the ultimate moment of resistance, depth of the neutral axis, limiting moment of resistance, and maximum depth of the neutral axis were proposed. An idealized load-deformation curve was also developed, which identified four significant events: first cracking, yielding of reinforced steel, crushing of concrete with spalling of cover, and ultimate failure. The predicted values were found to be in good agreement with the experimental values, and the average location of the first crack was identified to be 0.270 L, measured from the central support on either side of the span. These findings provide important insights for the design of HPC structures, contributing to the development of more resilient and durable infrastructure.
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http://dx.doi.org/10.1021/acsomega.3c01197 | DOI Listing |
Cardiovasc Res
September 2025
Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University in Saint Louis, St. Louis, MO, USA.
Aims: Although the ability of the heart to adapt to environmental stress has been studied extensively, the molecular and cellular mechanisms responsible for cardioprotection are not yet fully understood. In this study, we sought to elucidate these mechanisms for cytoprotection using a model of stress-induced cardiomyopathy.
Methods And Results: We administered Toll-like receptor (TLR) agonists or diluent to wild-type mice and assessed for cardioprotection against injury from a high intraperitoneal dose of isoproterenol (ISO) administered 7 days later.
Food Funct
September 2025
Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen, Fujian Province 361021, PR China.
Depression is a widespread mental health condition associated with impaired neuroplasticity and disrupted brain-derived neurotrophic factor (BDNF)/TrkB signaling. Black mulberry, rich in anthocyanins, shows promise as a natural intervention for its anti-oxidative and anti-inflammatory profiles. This study evaluated the antidepressant-like effects of black mulberry anthocyanins in mice subjected to chronic mild stress (CMS).
View Article and Find Full Text PDFBiochem Pharmacol
September 2025
Pharmacy College of Shihezi University/Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education/Institute for Safflower Industry Research of Shihezi University, Shihezi University, North 4th Road 221, Shihezi, China. Electronic address:
The etiology of alcoholic fatty liver (AFL) is complex, representing the early reversible stage of alcohol-associated liver disease (ALD). Alleviating oxidative stress, reducing inflammation, and preventing the development of liver fibrosis are considered the most effective strategies for treating AFL. Consequently, we selected isoliquiritigenin (ISL), a flavonoid compound recognized for its anti-inflammatory, antioxidant, and anticancer pharmacological properties.
View Article and Find Full Text PDFNeural Plast
September 2025
Department of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Astrocytes play a crucial role in ensuring neuronal survival and function. In stroke, astrocytes trigger the unfolded protein response (UPR) to restore endoplasmic reticulum homeostasis. Mesencephalic astrocyte-derived neurotrophic factor (MANF), a newly identified endoplasmic reticulum stress-induced neurotrophic factor, attenuates cerebral ischemic injury by reducing inflammatory responses.
View Article and Find Full Text PDFCureus
August 2025
Anesthesiology, Asahi General Hospital, Asahi, JPN.
Awake tracheal intubation (ATI) is a crucial technique for difficult airway management, particularly in patients with obesity, restricted neck movement, or upper airway abnormalities. Despite its efficacy, ATI is often avoided because of the technical challenges and stress it imposes on patients and anesthesiologists. We describe a new method, termed "intubation maintaining spontaneous breathing with three nerve blocks technique" (3N technique), which leverages nerve blocks to suppress reflexes, preserve spontaneous breathing, and facilitate smooth intubation.
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