First-in-human dosimetry and safety evaluation of Ga-αMSH derivative for PET imaging of melanoma.

Melanoma remains one of the leading causes of cancer-related mortality worldwide, necessitating advanced imaging techniques for early and accurate detection. This study assesses the dosimetry, safety, and imaging performance of a novel Ga-labeled α-melanocyte-stimulating hormone ([Ga]Ga-αMSH) derivative for targeting melanocortin 1 receptors (MC1Rs) in metastatic melanoma. In this first-in-human, prospective, open-label clinical trial, 11 patients with histologically confirmed metastatic melanoma underwent whole-body PET/CT imaging following intravenous administration of the radiolabeled compound (150 ± 10 MBq).

Bioremediation Performance of Recombinant Shewanella azerbaijanica; Considering Uranium Removal in the Presence of Nitrate.

Genetic engineering in microorganisms has emerged as a promising approach for pollutant removal from industrial wastewater. Shewanella azerbaijanica has the ability to reduce uranium. This study examined the impact of high-nitrate concentrations on uranium bioreduction in both native and recombinant bacterial strains.

Investigating the effect of thyroid shields and lead glasses on image quality and artefacts in cone beam computed tomography devices: A phantom study.

Introduction: The objective of this study is to investigate and compare the impact of thyroid shields and lead glasses on the image quality (IQ) and artefacts in dental Cone Beam CT (CBCT) images. The current study aims to evaluate the effectiveness of this protective equipment in enhancing the quality of dental CBCT images.

Methods: In this study, a New Tom dental CBCT device was used to scan Pro-Project phantom with and without thyroid shields and lead glasses in three different large, medium, and small Fields of View (FOVs).

Insight on long non-coding RNA expression profile in THP-derived macrophages infected by Mycobacterium tuberculosis H37Rv, H37Ra, and BCG.

Emerging evidence has suggested a potential role for long non-coding RNAs (lncRNAs) in transcriptome dysregulation during Mycobacterium tuberculosis (Mtb) infection. Understanding the regulatory functions of lncRNAs can provide further insight into the interaction between Mtb and the host. In this study, we sought to explore the lncRNA signature in the Mtb-infected THP1 macrophages (H37Rv, H37Ra, and BCG strains) using the publicly available RNA sequencing dataset of GSE162729.

Enhancing the adsorption of strontium (II) using TOPO impregnated Dowex 50 W-X8 resin.

In this research work, the adsorption of strontium ions from aqueous solutions was studied using Dowex 50 W-X8 resin loaded with TOPO extractant. This study introduces a novel TOPO-impregnated adsorbent with potential applications for efficient and cost-effective nuclear wastewater treatment. The influence of effective operational parameters such as initial pH of the solution, adsorbent dosage, initial strontium concentration in the solution, and contact time was evaluated.

Double 3 MJ dense plasma focus for thermonuclear drive inertial confinement fusion.

Nuclear fusion remains one of the most promising solutions for clean and sustainable energy production. However, significant challenges-including energy losses, plasma instabilities, and high operational costs-continue to hinder its practical realization. While magnetic confinement fusion (MCF) and inertial confinement fusion (ICF) have been the dominant approaches, dense plasma focus (DPF) devices present a compact and high-performance alternative.

Elucidating long non-coding RNA networks in tomato plants in response to Funneliformis mosseae colonization and cucumber mosaic virus infection.

Tomato plants face biotic challenges like infections by cucumber mosaic virus (CMV), a member of the Cucumovirus genus in the Bromoviridae family, as well as beneficial interactions, such as colonization by the symbiotic fungus Funneliformis mosseae, which belongs to the Glomeraceae family. While this symbiosis boosts nutrient uptake and stress tolerance, viral infections can reduce yield and quality. Understanding how tomatoes manage these interactions is vital for enhancing crop productivity.

Treatment of low-concentration uranium-containing wastewater utilizing Scenedesmus sp. with an emphasis on response surface methodology.

Microalgae possess various mechanisms to mitigate the toxicity of heavy metals. This study focused on the uranium removal potential of Scenedesmus sp. strain MTR 1901 from waters containing low concentrations of uranium contamination.

Investigation of the Oral Effects of Alcoholic Extract of Wild Yarrow () on Growth Performance, Immune, and Biochemical Serum Responses in Rainbow Trout ().

(AW), a plant rich in flavonoids, including lutein, apigenin, rutin, and phenolic compounds with antioxidant, antibacterial, and antifungal properties, is used in traditional medicine. In this study, the impact of AW extract on the growth, immune response, and biochemical indices of rainbow trout () was investigated. Over 8 weeks, fish were fed diets supplemented with varying concentrations of AW extract (0%, 0.

Gamma-ray and fast neutron shielding characteristics of inconel super alloys, stainless steel-304, and Pb using MCNPX, WinXCom, XMuDat, and Auto-Z software.

Fast neutron and gamma-ray attenuation characteristics of Inconel-600, -601, -625, and - 718 superalloys, stainless steel-304, and lead were studied using MCNPX Monte Carlo code, WinXCom, XMuDat, and Auto-Z computer programs. The µ, HVL, MFP, σ, σ, Z and N, and Σ were calculated for Ir, F, Cs, and Co gamma sources and 1 MeV fast neutrons. The difference between the MCNPX and calculated results was less than ± 2%.

Optimization of zirconia nanopowder precipitation process using Taguchi experimental design methodology.

The purpose of this research is to investigate the production of ZrO2 nano-powder from the product of the alkaline fusion process of Zircon mineral. The effect of surfactant type, solution pH, and calcination temperature were investigating using L9 orthogonal array in the Taguchi design of experiment method. The experiments related to the Preparation of Zirconia nano-powder were first performed on a synthetic solution prepared by dissolving Zirconium tetrachloride in deionized water.

The solvent extraction and stripping process using Alamine 336 with a case study of uranium.

In this research, a comprehensive study of the solvent extraction of uranium (VI) from acidic sulfate solutions using Alamine 336 diluted in kerosene was scrutinized. The effects of the contact time between the phases, sulfuric acid concentration, extractant concentration, uranium (VI) concentration, organic/aqueous phase ratio, and temperature were investigated. An extraction efficiency of around 99.

A survey on the determination of diagnostic reference levels in analog and digital radiography in Iran: a systematic literature review.

Introduction: Although ionizing radiation plays a key role in both diagnosis and treatment, it brings potential risks, including incidence of cancer. Diagnostic Reference Level (DRL) is described as a tool to optimize the protection in the medical exposure for diagnostic procedures. The objective of this study is to propose a new method to calculate DRL by reviewing a series of articles which are published on the DRL in radiography.

Helium and argon cold plasma effects on the 4T1 cancer cells and a triple negative mouse model of breast cancer.

Nowadays, cold atmospheric plasma (CAP) technology has developed as an innovative tool for cancer therapy. Although many studies have reported the antitumor effects of plasma in vivo and in vitro, there are many challenges, including standardization of plasma devices and treatment time for different tumors. For the first time, we aimed to evaluate and compare optimal exposure time and direction-dependent cellular effects of helium and argon plasma on the 4T1 cancer cells and a triple-negative mouse model of breast cancer.

[In]In-AMBA: A Novel Diagnostic Agent for SPECT Imaging of GRPR-Expressing Tumors.

Purpose: Gastrin-releasing peptide receptor (GRPR), a member of the bombesin G-protein-coupled receptor family, is introduced as the promising target for the diagnosis and therapy of various tumors. This study aimed to develop a novel diagnostic agent of [In]In-AMBA for single photon emission computed tomography (SPECT) imaging of GRPR expressing tumors.

Methods: In was provided from an in-house made Sn/In generator in the chloride form.

Corrigendum: Differential co-expression network analysis reveals key hub-high traffic genes as potential therapeutic targets for COVID-19 pandemic.

[This corrects the article DOI: 10.3389/fimmu.2021.

Corrigendum: Omics multi-layers networks provide novel mechanistic and functional insights into fat storage and lipid metabolism in poultry.

[This corrects the article DOI: 10.3389/fgene.2021.

Synthesis and characterization of antibacterial CMC/AAc/ZnO nanocomposite superabsorbent using gamma radiation.

CMC/AAc/ZnO, a novel antimicrobial superabsorbent hydrogel, was prepared via the copolymerization of carboxymethyl cellulose (CMC) and acrylic acid (AAc) by incorporating zinc oxide nanoparticles through gamma radiation. The morphological and structural properties were investigated with the aid of characterization techniques such as scanning electron microscopy (SEM), Fourier-transform infrared (FT-IR), energy dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), and thermogravimetric analysis (TGA) and Differential Scanning Calorimetry (DSC) analysis. In addition, the swelling behaviour analysis displayed superior pH-responsive performance in distilled water than in saline solutions.

Comprehensive systems biology analysis of microRNA-101-3p regulatory network identifies crucial genes and pathways in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide. This study aimed to explore the role of hsa-miR-101-3p in HCC pathogenesis by identifying key genes and pathways. A comprehensive bioinformatics analysis revealed twelve hub genes (ETNK1, BICRA, IL1R1, KDM3A, ARID2, GSK3β, EZH2, NOTCH1, SMARCA4, FOS, CREB1, and CASP3) and highlighted their involvement in crucial oncogenic pathways, including PI3K/Akt, mTOR, MAPK, and TGF-β.

Fabrication and validation of a new device for measuring the radiation dose in ethanol-chlorobenzene dosimeters based on oscillometry method.

This paper presents a novel digital instrument designed for measuring radiation doses in Ethanol-Chlorobenzene (ECB) dosimeters, based on oscillometry method. ECB dosimeters are versatile tools for radiation measurement, particularly in medical and industrial applications. Various components of the device including measuring cell, analog and digital circuits were designed, simulated, optimized and verified.

Genomic insights into Mediterranean pepper diversity using ddRADSeq.

This work investigated the genetic diversity and population structure of 99 pepper lines (Capsicum annuum L.), acclimated to Mediterranean climate conditions, using double-digest restriction site-associated DNA sequencing (ddRADSeq). The aims were to understand the genetic relationships among these lines, correlate genetic clusters with botanical classifications, and provide insights into pepper domestication in the region.

Corrigendum: Integrated network analysis to identify key modules and potential hub genes involved in bovine respiratory disease: a systems biology approach.

[This corrects the article DOI: 10.3389/fgene.2021.

Determining the optimal harvest time for pomegranate variety wonderful in semi-arid climate.

Due to limited local knowledge regarding the optimal harvest time for this non-native variety, a two-year study (2021-2022) was conducted using a randomized complete block design with four blocks. This study aimed to determine the ideal harvest time based on quantitative and qualitative fruit characteristics in saveh, which has a semi-arid climate. Twelve similarly sized trees were selected for each orchard, and fruits were harvested at three-time intervals: 155 days after flowering (DAF) (September 27), 170 DAF (October 12), and 185 DAF (October 27).

Corrigendum: Construction of a circRNA-lincRNA-lncRNA-miRNA-mRNA ceRNA regulatory network identifies genes and pathways linked to goat fertility.

[This corrects the article DOI: 10.3389/fgene.2023.

The Central Composite Design and Artificial Neural Network Coupled with Genetic Algorithm in Optimization and Modeling of the Radiolabeling Process of Lu-hydroxyapatite as a Potential Radiosynovectomy Agent.

Introduction: A promising material used in radiation synovectomy of small joints is hydroxyapatite, labeled with Lu. During the design and production of radiopharmaceuticals, the condition of the radiolabeling process directly influences the radiochemical yield and consequently the quality of the final product so this process necessitates precise optimization.

Methods: In this investigation, a central composite design based on response surface methodology and artificial neural networks modeling coupled with genetic algorithm technique is applied to build predictive models and explore key parameters' effect in hydroxyapatite's radiolabeling process with Lu radionuclide.