Misinformation in spinal cord rehabilitation on YouTube: Enhancing standards for patient safety.

BackgroundSpinal cord injury is a complex condition affecting millions globally, often requiring extensive rehabilitation. YouTube is increasingly utilized by spinal cord injury-patients and caregivers for rehabilitation information, despite potential misinformation risks. However, few studies have assessed the quality of spinal cord injury -related content on this platform.

Development of Receptor-Binding Domain (RBD)-Loaded PEG-PCL Nanoparticle Formulations Against SARS-CoV-2.

The COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 has highlighted the critical need for safe and effective vaccines. In this study, subunit nanovaccine formulations were developed using the receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein encapsulated in polymeric nanoparticles composed of poly(ethylene glycol)-block-poly(ε-caprolactone) (PEG-PCL). Two surfactants, poly(vinyl alcohol) (PVA) and sodium cholate (SC), were evaluated during formulation via a modified water-in-oil-in-water (w/o/w) emulsion-solvent evaporation method.

The impact of obesity and overweight on rheumatoid arthritis patients: real-world insights from a biologic and targeted synthetic DMARDs registry.

The Impact of Obesity and Overweight on Rheumatoid Arthritis Patients: Real-World Insights from a Biologic and Targeted Synthetic DMARDs Registry. The management of rheumatoid arthritis (RA) has advanced with biological and targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs). However, obesity, a common comorbidity, impacts treatment and disease progression efficacy.

Current Trends and Future Directions of Statistical Methods in Medical Research: A Scientometric Analysis.

Aims And Objective: The field of medical statistics has experienced significant advancements driven by integrating innovative statistical methodologies. This study aims to conduct a comprehensive analysis to explore current trends, influential research areas, and future directions in medical statistics.

Methods: This paper maps the evolution of statistical methods used in medical research based on 4,919 relevant publications retrieved from the Web of Science.

Effects of Progressive Muscle Relaxation on Pain and Sleep: Randomized Controlled Study.

Purpose: This study aimed to evaluate the effectiveness of Progressive Muscle Relaxation (PMR) on postoperative pain level and sleep quality in patients undergoing open heart surgery.

Design: A single center, two-group, single-blind randomized controlled trial.

Methods: This study comprised 60 patients who were admitted to the cardiovascular surgery department and undergoing open heart surgery between January 2023 and April 2024.

A systematic review of health promoting effects of consumption of whey-based fermented products on adults.

Introduction: Fermented whey-based products show significant potential as functional foods, owing to their rich nutritional profile and the generation of bioactive compounds during fermentation. This systematic narrative review evaluates the health effects of fermented-whey consumption based on evidence from human studies in adults.

Methods: A systematic literature search was conducted using electronic databases including, PubMed, Scopus, and Cochrane Library for studies published between 1.

Games and Gamification in Nursing: Mapping the Literature and Future Directions.

Background: Games and gamification have emerged as innovative tools in nursing, offering engaging and interactive approaches to enhance education and practice. Despite the increasing volume of research, gaps remain in understanding the current state of nursing literature.

Objectives: This research aims to map the trends, thematic foci, and research gaps in the field of gaming and gamification in nursing through bibliometric analysis.

Evaluation of creative project production performance in mathematical logic and computational thinking skills among gifted high school students.

This study examines the experiences of gifted high school students in transforming mathematical logic knowledge and skills into creative project productivity and computational thinking skills (CTS) through their logic-based project productions. A sequential exploratory mixed-methods research design was employed, involving 153 gifted youth. In the qualitative phase, a case study was used to examine the experiences of participants who attended the Logic-based Project Production and Management Program (PPMP) over 25 weekly sessions.

Temporal Variation of Biochemical Markers and Adenoma Predictors in Normocalcemic Primary Hyperparathyroidism: A Multicenter Retrospective Analysis.

Objective: This study aimed to evaluate the diagnostic performance of biochemical markers in normocalcemic primary hyperparathyroidism (nPHPT), analyse their temporal variations, and assess their correlation with adenoma localisation and size.

Methods: In this multicenter retrospective study-the largest patient cohort reported in the literature to date (n = 474) we comprehensively profiled normocalcemic patients diagnosed with primary hyperparathyroidism nPHPT was diagnosed based on persistently elevated PTH levels with normal serum calcium after excluding secondary causes such as vitamin D deficiency, renal impairment, and other conditions. This retrospective multicenter study included a large cohort of patients whose biochemical markers-including serum calcium, phosphorus, magnesium, vitamin D, parathyroid hormone (PTH), and glomerular filtration rate (GFR)-were measured at three time points, using standardised laboratory protocols.

The Mediating Role of Academic Resilience and Cognitive Test Anxiety in the Association Between Smartphone Addiction and Academic Achievement.

Objectives: Smartphone addiction is the loss of self-control resulting from excessive use of smartphones and is the most challenging addiction to daily life among technology addictions. Some studies explain the relationship between smartphone addiction and academic achievement. The purpose of this research is to examine the mediating effect of academic resilience, test anxiety, and general self-efficacy in the association between academic achievement and smartphone addiction.

Key considerations and recommendations for recruiting older adults in physical activity studies.

Background: Despite substantial evidence supporting the benefits of physical activity (PA) for older adults, participation rates remain low due to physical, psychological, social, and institutional barriers. Recruiting older adults for PA studies thus presents significant challenges, particularly for socially vulnerable populations and those facing digital literacy limitations in technology-assisted PA interventions. The present study aimed to articulate and establish a consensus among multidisciplinary and multinational PA experts regarding key considerations and requirements for designing and implementing recruitment of older adults for PA studies.

Evaluating the Effects of Nusinersen Treatment in Adults With Spinal Muscular Atrophy Using Axonal Excitability and MscanFit MUNE.

Introduction/aims: The biological changes in motor neurons and motor axons that correlate with the clinical benefits of nusinersen, an antisense oligonucleotide, in spinal muscular atrophy (SMA) remain poorly understood. This study aimed to investigate changes in axonal excitability and motor unit number estimation (MUNE) parameters following a four-dose loading regimen of nusinersen in adult SMA patients.

Methods: Adult patients with SMA were assessed using the Hammersmith Functional Motor Scale Expanded (HFMSE) and the Medical Research Council (MRC) scale at baseline and after nusinersen treatment.

TERT promoter mutations in meningiomas: associations with clinicopathological features and insights into spatial and temporal heterogeneity in a 165-case cohort.

Background: Although most meningiomas are benign, some behave aggressively despite low grade. We investigated the prognostic significance of TERT promoter (TERTp) mutations regarding clinicopathological features, heterogeneity, and outcomes.

Methods: A total of 165 meningiomas diagnosed between 2007 and 2019 were retrospectively re-evaluated according to the 2021 WHO CNS classification.

Detecting inactivity in aging populations: the discriminative potential of the physical activity scale for the elderly.

Background: Physical inactivity is a major global public health issue and ranks as the fourth leading modifiable risk factor for mortality from noncommunicable diseases and a major cause of disability. One of the questionnaires used to assess levels of physical activity in older adults is the Physical Activity Scale for the Elderly (PASE). The aim of this study was to determine the cut-off value of the PASE for physical inactivity in older adults.

Prevalence of Hidradenitis Suppurativa: A Meta-Analysis of Global Hidradenitis Suppurativa Atlas Studies.

Importance: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with a substantial burden. Standardized global prevalence estimates and data on associated sociodemographic and risk factors are lacking.

Objective: To estimate the global prevalence of HS and study differences in prevalence by age, sex, geographical location, body mass index (BMI; calculated as weight in kilograms divided by height in meters squared), smoking status, gross domestic product (GDP), and Human Development Index (HDI).

Instructor-Assisted Synchronous Online versus Face-to-Face Suturing Training: Effects on Learning and 3-Month Retention in a Randomized Controlled Trial.

BackgroundThis study evaluates the learning and retention of basic suturing skills among pre-graduate medical students through instructor-assisted synchronous online (ASO) vs face-to-face (FF) instruction.MethodsA randomized controlled experimental design was used in the practice laboratory of Cumhuriyet University Faculty of Medicine. Sixty second-year medical students without prior suturing experience were randomly assigned to FF or ASO groups.

Percutaneous renal biopsy adverse event rates: Coaxial or non-coaxial technique.

The purpose of this study was to compare the coaxial and non-coaxial techniques in terms of adverse events (AEs) resulting from the percutaneous renal biopsy. A secondary aim was to determine the potential effect of the sclerosed glomeruli on AEs. Patients who underwent ultrasonography-guided percutaneous renal biopsy in our interventional radiology clinic between January 2013 and December 2021 were scanned retrospectively.

Mapping Hot Spots and Global Research Trends in Exergaming Between 1997 and 2024: Bibliometric Analysis.

Background: Exergaming, the combination of exercise and gaming, has emerged as an important area in physical activity (PA) research. By leveraging advances in video game technology, exergaming supports both physical and mental health. This growing interest in exergaming has increasingly attracted researchers over the years.

Targeted Gene Editing in Honey Bees Using Liposome-Based CRISPR-Cas9.

Genome editing technologies have revolutionized molecular biology, enabling precise manipulation of gene functions across diverse organisms. In this study, we introduce a novel liposome-mediated delivery system for CRISPR-Cas9 components targeting the Juvenile Hormone Acid Methyltransferase (JHAMT) gene in honey bees (Apis mellifera anatoliaca). This approach leverages drone sperm cells as vectors for CRISPR-Cas9 transfection, overcoming the technical challenges of embryo microinjection in honey bees, such as low survival rates and labor-intensive procedures.

The Effect of Transition Model-Based Discharge Training for Mothers of Late Preterm Infants (TRAMPRE): A Randomized Controlled Study.

The aim of the study was to evaluate the effect of Transition Model-Based Discharge Training for Mothers of Preterm Infants (TRAMPRE) on (1) Kenner's three components of the transition to home; (2) post-partum depression; (3) unplanned hospital/family health center visits; and (4) post-discharge complications. Our study was conducted with 133 mothers who received services in the NICU of a hospital providing tertiary health care in Türkiye. The content of the intervention protocol consists of "Discharge Training for Mothers on Infant Care," the "Preterm Infant Care Guide," and "Telephone Follow-up and Counseling.

Enhancement of Ellagic Acid Solubility and Bioaccesibility by Microencapsulation Process and Biotransformation to Urolithins.

The aim of this study was to enhance the stability and water solubility of ellagic acid (EA) from pomegranate peel by microencapsulation using various carriers, and to improve its biotransformation into urolithin A (Uro-A) and urolithin B (Uro-B) by a probiotic microorganism. The formulation of carrier materials, comprising maltodextrin, inulin, and gum Arabic, and the inlet air temperature of the spray-drying microencapsulation process were optimized to enhance the stability and water solubility of EA. In addition to the variable ratios of carrier materials, a fixed concentration of β-cyclodextrin (1.

The Relationship Between Self-Efficacy, Self-Care, Health Literacy and Health-Related Quality of Life in People With Spinal Cord Injury: A Study Based on Regression Analysis.

Objectives: This study aims to determine the relationship between self-care ability, health literacy (HL) and self-efficacy of people with spinal cord injury (PSCI) and their quality of life (QoL); and to evaluate it within the framework of Bandura's social cognitive theory.

Method: This descriptive and relational study was carried out among 273 PSCI. Data for the study were collected using a descriptive information form, the American Spinal Injury Association Impairment Scale (ASIA), Self Efficacy-Sufficiency Scale (SE-SS), Health Literacy Survey Europa (HLS-EU), Self-Care Agency (SCA), World Health Organization Quality of Life Scale-Brief-Turkish (WHOQOL-BREF-TR).

How Risky Pregnant Women Achieve Positive Antenatal Experience: A Cross-Sectional Study of Examination of the Sense of Coherence, Prenatal Distress, and Pregnancy Acceptance.

Rationale: Antenatal care incorporating a health-promoting approach should focus on positive pregnancy experiences. This approach can bring pregnant women closer to the health dimension.

Aims And Objectives: To examine the effects and explanatory power of sense of coherence and prenatal distress on pregnancy acceptance among high-risk pregnancies.

The Effect of Breast Cancer Risk Reduction Program Applied to Women With High Breast Cancer Risk on Participation in Screening, Health Beliefs, and Behavior: A Randomized Controlled Trial.

Background: Women with a family history of breast cancer at an early age (≤50 years) have an increased risk of breast cancer themselves.

Objective: To evaluate the effectiveness of a Breast Cancer Risk Reduction Program (BrCaRRP) on increasing risk reduction behaviors, developing health beliefs, and screening participation in high-risk women with a family history of breast cancer.

Methods: This is a single-center, single-blind, parallel-group, randomized controlled trial.