Reproducibility of fixed-node diffusion Monte Carlo across diverse community codes: The case of water-methane dimer.

Fixed-node diffusion quantum Monte Carlo (FN-DMC) is a widely trusted many-body method for solving the Schrödinger equation, known for its reliable predictions of material and molecular properties. Furthermore, its excellent scalability with system complexity and near-perfect utilization of computational power make FN-DMC ideally positioned to leverage new advances in computing to address increasingly complex scientific problems. Even though the method is widely used as a computational gold standard, reproducibility across the numerous FN-DMC code implementations has yet to be demonstrated.

Expansion of aerobic methanotrophy to the phylum of Actinomycetota and its environmental implications.

For over a century, taxonomically validated pure cultures of aerobic methanotrophs belonged to Pseudomonadota, or since 2007, Verrucomicrobiota. A recent article published in by H. Kambara, T.

Effect of increased CpG and UpA dinucleotides in the West Nile virus genome on virus transmission by mosquitoes and pathogenesis in a vertebrate host.

Vertebrate animals and many small DNA and single-stranded RNA viruses that infect vertebrates have evolved to suppress genomic CpG dinucleotides. All organisms and most viruses additionally suppress UpA dinucleotides in protein-coding RNA. Synonymously recoding viral genomes to introduce CpG or UpA dinucleotides has emerged as an approach for viral attenuation and vaccine development.

Roots: metabolic architects of beneficial microbiome assembly.

The increasing demand for sustainable agricultural practices has driven a renewed interest in plant-microbiome interactions as a basis for the next "green revolution." Central to these interactions are root-derived metabolites that act as mediators of microbial recruitment and function. Plants exude a chemically diverse array of compounds that influence the assembly, composition, and stability of the root microbiome.

Surgical Nurses' Perspectives on Low-Value Care and Non-Nursing Tasks: A Cross-Sectional Study.

Background: Low-value care provides little or no benefit to patients, or its risk of harm outweighs the potential benefits. Non-nursing tasks refer to tasks performed by nurses below their scope of practice. With increasing pressure on the global nursing workforce, it is necessary to identify these concepts to deliver fundamental care.

Complete genome sequence of a putative novel orthotospovirus species identified in fruits from South Africa.

We report two complete genome sequences of a putative novel orthotospovirus species in pepper fruits ( sp.) from South Africa, provisionally named (Capsicum orthotospovirus 1; CaV1). Its nucleocapsid protein shows less than 88% amino acid identity with other orthotospoviruses.

Doubly Robust Control Outcome Calibration Approach Estimation of Conditional Effects with Uncontrolled Confounding.

Drawing causal conclusions about nonrandomized exposures rests on assuming no uncontrolled confounding, but it is rarely justifiable to rule out all putative violations of this routinely made yet empirically untestable assumption. Alternatively, this assumption can be avoided by leveraging negative control outcomes using the control outcome calibration approach (COCA). The existing COCA estimator of the average causal effect relies on correctly specifying the mean negative control outcome model, with a closed-form solution for the main exposure effect.

Characteristics of Ongoing Clinical Trials for Cocaine Use Disorder Registered on Global Clinical Trial Databases.

Objectives: Cocaine use disorder (CUD) affects 1.4 million people in the United States, yet no FDA-approved treatments exist. In 2023, the Food and Drug Administration (FDA) released a draft guideline on treatments for stimulant use disorders, providing direction for trial design, outcomes, and population selection.

Preventing Glioblastoma Relapse by Igniting Innate Immunity through Mitochondrial Stress in the Surgical Cavity.

Innate immunity is crucial in orchestrating the brain immune response, however, glioblastoma multiforme (GBM) has evolved sophisticated mechanisms to evade innate immune surveillance, posing significant challenges for current immunotherapies. Here, a therapeutic strategy is reported that aims at reactivating innate immune responses in GBM via targeted induction of mitochondrial stress, thereby enhancing tumor immunogenicity. Specifically, innate immune-stimulating nanoparticles (INSTNA) are developed, encapsulating positively charged iridium-based complexes (Ir-mito) and small interfering RNA against Methylation-Controlled J protein (si-MCJ) to attenuate mitochondrial respiration.

Micro-Strain Responsive Near-Infrared Mechanoluminescence for Potential Nondestructive Artificial Joint Stress Imaging.

Recently, joint replacement surgery is facing significant challenges of patient dissatisfaction and the need for revision procedures. In-situ monitoring of stress stability at the site of artificial joint replacement during postoperative evaluation is important. Mechanoluminescence (ML), a novel "force to light" conversion technology, may be used to monitor such bio-stress within tissues.

Universal Scale for Child Development Predicts Limited Intellectual Functioning at an Early Stage.

Aim: Early identification of limited intellectual functioning is important for providing support. This study investigated whether a universal child development score (D-score) at 12, 24 and 36 months can predict limited intellectual functioning at 5-10 years of age, in addition to neonatal and parental characteristics.

Methods: A case-control study using developmental milestones and health records from three Dutch child healthcare organisations.

Infant protection from invasive type b disease using the PRP-OMPC conjugate vaccine: An update.

Invasive disease caused by type b (Hib) is a major health concern, particularly in children under 5 years of age and vulnerable populations. Use of Hib conjugate vaccines has significantly reduced the incidence of Hib disease. Among these, the polyribosylribitol phosphate-outer membrane protein complex (PRP-OMPC) conjugate has demonstrated uniquely robust immunogenicity in infants compared to PRP conjugated to tetanus toxoid.

Brexpiprazole in the Management of Schizophrenia: A Consensus Report of Best Practices From Acute to Maintenance Treatment.

Brexpiprazole is a second-generation antipsychotic with multiple indications, including the treatment of schizophrenia. As a partial dopamine agonist, brexpiprazole differs from most other antipsychotics, yet uncertainties about its full mechanism of action have led to some ambiguity among prescribers. To address this gap, an international panel of psychiatric experts was organized and convened with funding from Otsuka Pharmaceutical Europe Ltd and H.

Impact of secondary anterior-posterior defibrillator pad placement on chest compression interruptions: a three-arm randomised manikin-based simulation study among Dutch ambulance teams.

Background: Out-of-hospital cardiac arrest management prioritises effective treatment, with high-quality chest compressions and timely defibrillation being essential. While current European Resuscitation Council guidelines recommend sternal-apical defibrillator pad placement, alternative positions such as anterior-posterior (AP) are gaining interest. The integration of secondary AP pad placement with mechanical cardiopulmonary resuscitation devices (mCPR) remains underexplored.

Guided and motor imagery for pain management and functional recovery after arthroplasty of the hip or knee: A pragmatic prospective mixed-methods study.

Background: Athroplastic surgery often results in acute post-operative pain, hindering rehabilitation compliance. To improve pain management and functional recovery, guided and motor imagery (GMI) exercises were introduced in hip and knee arthroplasty.

Methods: A pragmatic prospective mixed-methods implementation evaluation was conducted at the orthopaedic department of Schakelring, the Netherlands.

International Ski and Snowboard Federation (FIS) consensus statement on training and testing in competitive alpine and freestyle skiers and snowboarders.

To enhance performance, increase resilience and prevent injuries, training and testing (T&T) are the most important strategies for preparing athletes for the demands of their sport. However, for competitive snow sports such as alpine skiing, freestyle skiing and snowboarding, there is little evidence and a lack of international harmonisation of current best practices. This consensus statement, commissioned by the International Ski and Snowboard Federation (FIS), aims to provide recommendations for the physical and psychological T&T of competitive alpine and freestyle skiers and snowboarders within National Ski and Snowboard Associations.

Adherence to the EAT-lancet dietary pattern among older adults in Rwanda and its association with micronutrient intake.

Background: Sub-Saharan Africa is facing a dietary transition with both undernutrition and rising rates of non-communicable diseases. Adopting the reference diet proposed by the EAT-Lancet Commission can reduce both the environmental burden and improve health outcomes. However, whether this diet provides micronutrient adequacy in older adults in low-income settings has not been investigated.

Innovations in communication training for medical and nursing students: Virtual reality communication tool for application and evaluation with key stakeholders and students (VR-TALKS) - a study protocol.

Background: In healthcare education, virtual reality (VR), simulating real-world situations, is emerging as a tool to improve communication skills, particularly in sensitive scenarios involving patients and caregivers. While promising, VR-based education also poses challenges such as avatar realism, cognitive load, and the need for pedagogical grounding.

Objective: This protocol paper presents the VR-TALKS project, which aims to develop, apply, and evaluate VR scenarios designed to teach healthcare students communication skills in serious illness scenarios.

Do turtles get cancer?

Turtles are renowned for their extreme longevity and tremendous range in body size. Theoretically, large, long-lived organisms should face higher cancer risks because of increased cell numbers and lifetime cellular turnover, yet cancer appears to be exceptionally rare in turtles. In the present article, we synthesize the current knowledge on cancer prevalence in turtles, drawing from zoo necropsies, pathology reports, and comparative oncology studies, and present new data spanning additional species that reinforce this pattern.

Subgaleal Hematoma in a Female With Normal Coagulation Tests.

Factor XIII (FXIII) deficiency is a rare coagulopathy with an estimated prevalence of approximately 1 in 1 to 2 million, affecting males and females with equal frequency. FXIII plays a critical role in hemostasis by stabilizing fibrin clots through covalent cross-linking of fibrin monomers, thereby conferring mechanical resistance and durability to the clot structure. Clinically, FXIII deficiency presents with a spectrum of hemorrhagic manifestations including bleeding from the umbilical cord, intracranial hemorrhage, recurrent miscarriages, menorrhagia, epistaxis, gingival bleeding, and poor wound healing.

Airport/seaport and autochthonous malaria in Europe from 1969 to 2022: A systematic review.

Background: In the context of this paper, airport/seaport malaria denotes the accidental relocation by air or sea of a malaria infected mosquito to Europe, a non-endemic area, the survival of the transported mosquito and subsequent blood meal and infection of a local person. Autochthonous malaria refers to locally transmitted cases of malaria in Europe.

Methods: The systematic review followed PRISMA guidelines and was registered on PROSPERO (CRD42023444243).

CuSn Gd S thin films for photocatalytic degradation of methylene blue.

Thin films of CuSn Gd S were prepared on soda-lime glass substrates using spin coating in a sulfur-rich environment. We investigated how doping CuSnS with gadolinium (Gd) affected its structural, morphological, and optical properties using X-ray diffraction (XRD), Raman spectroscopy, field emission scanning electron microscopy (FE-SEM), and UV-Vis spectroscopy. XRD showed that all samples had a polycrystalline monoclinic structure, while FE-SEM revealed a mix of spherical and polygon-shaped grains.

On the graph theory of majority illusions: theoretical results and computational experiments.

Unlabelled: The popularity of an opinion in one's direct circles is not necessarily a good indicator of its popularity in one's entire community. Network structures make local information about global properties of the group potentially inaccurate, and the way a social network is wired constrains what kind of information distortion can actually occur. In this paper, we discuss which classes of networks allow for a large enough proportion of the population to get a wrong enough impression about the overall distribution of opinions.