Cast Versus Surgery for Displaced Intra-Articular Distal Radius Fractures in the Elderly a Randomized Clinical Noninferiority Trial (the DART Study).

Background: Evidence supporting surgery in elderly patients with distal radius fractures is limited, but displaced fractures may benefit from surgery. This study aimed to determine whether casting is noninferior to surgery for patients aged 65 years or older with substantially displaced intra-articular (AO type C) distal radius fractures.

Methods: This multicenter randomized controlled noninferiority trial included 138 patients (mean age 76 years, SD 6.

Reducing Calibration Bias for Person Fit Assessment by Mixture Model Expansion.

Measurement appropriateness concerns the question of whether the test or survey scale under consideration can provide a valid measure for a specific individual. An aberrant item response pattern would provide internal counterevidence against using the test/scale for this person, whereas a more typical item response pattern would imply a fit of the measure to the person. Traditional approaches, including the popular Lz person fit statistic, are hampered by their two-stage estimation procedure and the fact that the fit for the person is determined based on the model calibrated on data that include the misfitting persons.

Value change debt as a window of opportunity for transformative change: a case study on the mixed Indigenous food system of St. Paul Island, Alaska.

Unlabelled: Arctic Indigenous food systems are essential to the survival of local communities, but face significant challenges due to environmental, economic, and social pressures. The objective of this study is to elicit values of the mixed Indigenous food system on St. Paul Island, Alaska, and understand their potential as deep leverage points for transformative change in the context of their historical co-evolution with the local food system.

Re-territorialising skills? Insights from ethnography on solidarity-economy food activism.

The article addresses the role of citizens in setting up short food chains in the framework of the solidarity economy movement in Lombardy, Italy. On the basis of ethnographic fieldwork with solidarity economy activists and longitudinal ethnography (2009-2023), the article critically analyses solidarity-driven experimentations with local food systems, including direct bulk-buying from farmers and setting up a Participatory Guarantee System (PGS) to self-certify organic agriculture quality standards as attempts at (re)territorialising the food chain. This implies innovative relationships and practices connecting farmers and consumers in a role for citizens as 'co-producers'.

Executive and Social Functioning in Children and Adolescents With Noonan Syndromes: Cognition and Behavior.

Objective: The current study aims to examine executive and social functioning in children and adolescents with Noonan syndromes, which contributes to the understanding of the cognitive and behavioral profile of this population and possible treatment options.

Method: A total of 26 children and adolescents with Noonan syndromes (including Noonan syndrome, Noonan syndrome with multiple lentigines, and Noonan-like syndrome with loose anagen hair; mean age = 11.92 years, SD = 2.

Prediction of Hepatocellular Carcinoma and Other Liver-Related Events in Chronic Hepatitis B Patients With Metabolic Dysfunction or Metabolic Dysfunction-Associated Steatotic Liver Disease.

Introduction: Metabolic dysfunction and metabolic dysfunction-associated steatotic liver disease (MASLD) are associated with an increased risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). We aimed to study risk factors for HCC and to assess the performance of the PAGE-B score in this population.

Methods: We included CHB patients with ≥ 1 metabolic comorbidity from nine centres.

Reperfusion Therapy for ST Elevation Myocardial Infarction in Low to Middle-Income Countries. A Clinical Consensus Statement of the Association for Acute CardioVascular Care (ACVC), the European Association of Percutaneous Cardiovascular Interventions (EAPCI), the European Association of Preventive Cardiology (EAPC), the ESC Working Group on Thrombosis, and the Stent - Save a Life! Initiative.

Suboptimal care for ST-elevation myocardial infarction (STEMI) in low- and middle-income countries is a significant problem. Registries from Latin America, Africa, and Asia show that less than 65% of patients receive reperfusion therapy, and widespread treatment delays and a lack of access to optimal therapies lead to preventable deaths and complications. While current guidelines provide a blueprint for care, their implementation in low-resource settings requires specific guidance that considers geographical, logistical, and economic realities.

Feasibility of Measuring Hair Glucocorticoids as a Potential Biomarker for Chronic Stress in Older Adults With Intellectual Disabilities.

Background: Chronic stress can significantly impact health, leading to conditions such as cardiovascular disease and mental health issues. Detecting chronic stress in older adults with intellectual disabilities (ID) is challenging, but measuring scalp hair glucocorticoids (HairGC) may offer a solution. This study aims to investigate the feasibility of measuring HairGC in older adults with ID and assess reasons for failed sample collection and analysis.

Epidemiology and burden of mild/moderate versus high myopia in Germany: A claims data analysis.

Purpose: This study aimed to investigate the prevalence, healthcare resource utilization (HCRU) and associated costs of myopia in Germany, comparing mild/moderate and high myopia across various age groups using real-world data.

Methods: A retrospective cross-sectional study was conducted using data from the WIG2 benchmark database. Patients with a diagnosis of myopia (ICD-10-GM H52.

Better movers, better friends? A test for the environmental stress hypothesis in typically developing primary school children.

Relations between children's motor skills and internalizing problems are poorly understood. The environmental stress hypothesis (ESH), originally developed for motor-impaired children, may provide understanding, yet has been scarcely examined in typically developing children. Therefore, we examined: (1) relations between children's motor skills and internalizing problems; (2) the role of secondary stressors, specifically interpersonal conflicts and externalizing problems; and (3) the role of personal resources, namely, prosocial behaviour and social self-efficacy (SSE).

Brief Evaluation of Olink Reveal Proximity Extension Assay for High-Throughput Proteomics: A Case Study Using NIST SRM 1950 and Two Spike-In Protein Standards.

Plasma proteomics has regained attention in recent years through advancements in mass spectrometry instrumentation and sample preparation as well as new high-throughput affinity-based technologies. Here, we evaluate the analytical performance of the new Olink Reveal platform, a proximity extension assay (PEA)-based technology quantifying 1034 proteins and covering many biological pathways, in particular immune system processes. Using spiked-in recombinant Interleukin-10 (IL-10) and vascular endothelial growth factor D (VEGF-D) in the NIST SRM 1950 plasma standard, we assessed the linearity, sensitivity, precision, and accuracy of the Olink Reveal assay.

Mastery-Oriented or Outcome-Oriented Help? How Recipient Ethnicity and Task Difficulty Shape Children's Helping Behavior.

Teachers and parents often scaffold children to help others. Not all help is equally beneficial, however. We know very little about the ways in which children distribute different types of help.

Malaria amidst the COVID-19 pandemic in Gabon: an application of autoregressive integrated moving average (ARIMA) models within an interrupted time series (ITS) framework to hospital-based data.

Background: Coinciding with the SARS-CoV-2 pandemic, malaria cases and malaria-related deaths increased globally between 2020 and 2022. However, evidence linking the pandemic to increased malaria burden remains ambiguous. We assessed the extent to which an observed malaria resurgence in Lambaréné, Gabon, can be associated with pandemic-related disruptions in malaria control programmes.

The Scolioscope: a home detection tool for measuring axial trunk rotation in scoliosis-a validation study.

Purpose: Screening for adolescent idiopathic scoliosis (AIS) using the Adam Forward Bending Test (AFBT) remains controversial, resulting in the discontinuation of scoliosis screening in the Netherlands. This study aims to validate the Scolioscope, a simplified version of the Scoliometer, for detecting scoliosis in a home setting.

Methods: A validation study was conducted at the orthopedic outpatient clinic of Erasmus Medical Center Sophia Children's Hospital in Rotterdam, the Netherlands.

Mapping the dynamics of seagrass aboveground carbon stock in a developing coastal area: case study of Kuta Mandalika, Lombok Island, Indonesia.

Understanding seagrass dynamics is crucial for the effective management and conservation of seagrass meadows. However, such information remains limited for many regions worldwide, including Kuta Mandalika on Lombok Island, Indonesia. This rapidly developing coastal area, which is home to both tourism infrastructure and an international race circuit, hosts extensive seagrass meadows whose condition and dynamics require careful assessment.

Heterologous two-dose Ebola vaccine regimen in pregnant women in Rwanda: a randomized controlled phase 3 trial.

Risk of death for both mother and fetus following Ebola virus infection is extremely high. In this study, healthy women in Rwanda aged ≥18 years were randomized to two-dose Ebola vaccination (Ad26.ZEBOV, MVA-BN-Filo) during pregnancy (group A) or postpartum (group B).

Applying evolutionary theory to understand host-microbiome evolution.

All plants and animals are host to a community of microorganisms, their microbiotas, which have crucial influences on the life history and performance of their hosts. Despite the importance of such host-microbiota relationships, relatively little is known about the role microbiotas have in mediating evolution of the host and entire host-microbe assemblages. This knowledge gap is partly due to the lack of theoretical frameworks that generate testable predictions on the evolutionary dynamics of host-microbiota systems.

Healthcare workers' sustainable employability in relation to quality of care: an umbrella review.

Objectives: There is a wealth of reviews investigating the relations between healthcare worker (HCW) variables and quality of care (QoC) outcomes. Individually, these reviews predominantly focus on one aspect relevant to HCWs' functioning at work, unintentionally contributing to a scattered body of evidence. This umbrella review uses the concept of sustainable employability (SE)-a multidimensional construct that captures an individual's long-term ability to function adequately at work and in the labour market-to integrate existing reviews on the topic, and to examine if and how HCWs' SE is related to QoC.

Randomized clinical efficacy and safety study of peltopepimut-S plus cemiplimab compared to cemiplimab alone in patients with recurrent/metastatic HPV16-positive head and neck cancer.

Background: Peltopepimut-S is a therapeutic vaccine, which induces specific expansion of both CD4+helper and CD8+cytotoxic T-cells against human papillomavirus type 16 (HPV16) E6/E7 oncoproteins.

Patients And Methods: In a randomized phase 2 trial, we evaluated the efficacy and safety of peltopepimut-S plus cemiplimab compared with cemiplimab alone as first-line or second-line therapy in recurrent/metastatic HPV16-positive head and neck cancer. The primary efficacy endpoint was the objective response rate (ORR) by an independent review (Response Evaluation Criteria in Solid Tumors version 1.

Digital respiratory technologies across the lifespan: an overview of opportunities and challenges from children to older adults.

Topic Importance: Digital health technologies (DHT) such as mobile health technologies, wearables, telehealth and telemonitoring are increasingly used in healthcare. This is particularly true for respiratory conditions such as asthma, cystic fibrosis, tuberculosis, interstitial lung disease and COPD as DHTs can support diagnosis, self-management, and ongoing care. However, respiratory conditions change across an individual's lifespan in both their presentation and management priorities for the clinician and patient.

Impact of centre experience on complete clinical and haemodynamic response after alcohol septal ablation for hypertrophic obstructive cardiomyopathy.

Background: Alcohol septal ablation (ASA) is an established therapy for symptomatic hypertrophic obstructive cardiomyopathy (HOCM) in patients unresponsive to medical treatment. However, comprehensive assessment of ASA outcomes remains challenging. This study aimed to evaluate the impact of institutional experience and patient characteristics on achieving complete clinical and haemodynamic response (CCHR), a novel composite outcome integrating long-term symptomatic, haemodynamic, safety, and major clinical endpoints, including survival and resuscitation.