A geometric condition for robot-swarm cohesion and cluster-flock transition.

We present a geometric design rule for size-controlled clustering of self-propelled particles. We show that active particles that tend to rotate under an external force have an intrinsic, signed parameter with units of curvature which we call curvity, that can be derived from first principles. Experiments with robots and numerical simulations show that properties of individual robots (radius and curvity) control pair cohesion in a binary system, and the stability of flocking and self-limiting clustering in a swarm, with applications in metamaterials and in embodied decentralized control.

Evaluating the predictive accuracy of cognitive screeners BAMCOG and MoCA in identifying postoperative delirium risk in aortic valve replacement patients: A cohort study.

Postoperative delirium (POD) and postoperative encephalopathy (POE) are common complications in older adults undergoing aortic valve replacement (AVR), yet the predictive accuracy of cognitive screening tools remains uncertain. In this prospective cohort study, 50 patients aged 65 years and older scheduled for AVR between January and October 2022 underwent preoperative assessment with the Brain Aging Monitor Cognitive Assessment (BAMCOG) and Montreal Cognitive Assessment (MoCA). Postoperatively, POD was evaluated with the Delirium Observation Screening (DOS) scale and POE with electroencephalography (EEG).

Pain, Agitation, Delirium, and Iatrogenic Withdrawal Syndrome Management in Children Who Are Critically Ill: Protocol for a European Clinical Practice Guideline Using the Grading of Recommendations Assessment, Development, and Evaluation Approach.

Background: In pediatric intensive care units, pain, sedation, delirium, and iatrogenic withdrawal syndrome (IWS) must be managed as interrelated conditions. Although clinical practice guidelines (CPGs) exist, new evidence needs to be incorporated, gaps in recommendations addressed, and recommendations adapted to the European context.

Objective: This protocol describes the development of the first patient- and family-informed European guideline for managing pain, sedation, delirium, and IWS by the European Society of Paediatric and Neonatal Intensive Care.

A Study of Academics' Perceptions of Ethical Implications of Generative Artificial Intelligence on Scientific Research and Publishing.

This study investigates how scientists, educators, and ethics committee members in Türkiye perceive the opportunities and risks posed by generative AI and the ethical implications for science and education. This study uses a 22-question survey developed by the EOSC-Future and RDA AIDV Working Group. The responses were gathered from 62 universities across 208 universities in Türkiye, with a completion rate of 98.

Associations of adherence to the World Cancer Research Fund lifestyle recommendations with health-related quality of life and fatigue in Adolescent and Young Adult (AYA) cancer survivors: results from the SURVAYA study.

Purpose: Adolescents and young adults (AYAs) with cancer face unique long-term social and health challenges that impact their health-related quality of life (HRQoL). This study explores the association between lifestyle behaviors (physical activity, body composition, and nutrition) and HRQoL as well as fatigue in AYA cancer survivors.

Methods: The cross-sectional SURVAYA study analyzed data from long-term AYA cancer survivors (5-20 years post diagnosis, aged 18-39 at diagnosis) in The Netherlands.

Electrical impedance myography captures features of muscle structure measured by MRI and transcriptomic analysis in facioscapulohumeral muscular dystrophy.

Background: Electrical impedance myography (EIM) has been proposed as an efficient, non-invasive biomarker of muscle composition in facioscapulohumeral muscular dystrophy (FSHD).

Objective: We investigate whether EIM parameters are associated with muscle structure measured by magnetic resonance imaging (MRI), muscle histology, and transcriptomic analysis as well as strength at the individual leg muscle level.

Methods: We performed a multi-center cross-sectional study enrolling 33 patients with FSHD.

Surgical Nurses' Perspectives on Low-Value Care and Non-Nursing Tasks: A Cross-Sectional Study.

Background: Low-value care provides little or no benefit to patients, or its risk of harm outweighs the potential benefits. Non-nursing tasks refer to tasks performed by nurses below their scope of practice. With increasing pressure on the global nursing workforce, it is necessary to identify these concepts to deliver fundamental care.

Impact of secondary anterior-posterior defibrillator pad placement on chest compression interruptions: a three-arm randomised manikin-based simulation study among Dutch ambulance teams.

Background: Out-of-hospital cardiac arrest management prioritises effective treatment, with high-quality chest compressions and timely defibrillation being essential. While current European Resuscitation Council guidelines recommend sternal-apical defibrillator pad placement, alternative positions such as anterior-posterior (AP) are gaining interest. The integration of secondary AP pad placement with mechanical cardiopulmonary resuscitation devices (mCPR) remains underexplored.

Long way to impact health: outputs and outcomes of a four-year multilevel participatory family health promotion programme in a low-income neighbourhood.

Introduction: Improving health, in particular of people in a disadvantaged socioeconomic position (SEP), requires multilevel health promotion programmes with community engagement. However, the impacts of such complex and challenging programmes are not yet clear. This study aims to show the impact of a participatory multilevel family health promotion programme in a low-income neighbourhood at intrapersonal, interpersonal, organisational, community and policy level.

Quantification of neuroinflammation in spinal cord and neuroforamina of patients with painful cervical radiculopathy using [C]DPA713 PET/CT.

Background: Animal models of nerve compression have revealed neuroinflammation not only at the entrapment site, but also remotely at the spinal cord. However, there is limited information on the presence of neuroinflammation in human compression neuropathies. The objectives of this study were to: (1) assess which tracer kinetic model most optimally quantified [C]DPA713 uptake in the spinal cord and neuroforamina in patients with painful cervical radiculopathy, (2) evaluate the performance of linearized methods (e.

Glycoproteomics analysis of complement factor H and its complement-regulatory function during -associated hemolytic uremic syndrome.

Hemolytic uremic syndrome caused by an invasive infection (SP-HUS) is a rare and severe disease that primarily affects children under two years of age. The pathophysiology of SP-HUS remains poorly understood, and treatment is largely supportive. Complement factor H (FH) is a key regulator of the alternative pathway of the complement system.

A genome-wide association study identifies new loci associated with response to SARS-CoV-2 mRNA-1273 vaccine in a cohort of healthy healthcare workers.

Introduction: The COVID-19 pandemic had significant global public health consequences, affecting over 200 countries and regions by 2020. The development and efficacy of specific vaccines, such as the mRNA-1273 (Spikevax) vaccine developed by Moderna Inc., have substantially reduced the impact of the pandemic and mitigated its consequences.

The illusory perception of occluded space as empty depends on the occluded area.

Some occluders evoke the compelling impression that the space behind them is empty. Stage magicians use this illusion of absence to produce objects out of thin air. The generic view principle predicts that the illusion of absence should increase with decreasing occluder size.

High- and intermediate-risk pulmonary embolism in pediatric tertiary care centers in the Netherlands.

Background: Pulmonary embolism (PE) response teams are increasingly used in adult care to improve severe PE management. Understanding the epidemiology, treatment, and outcomes of severe PE in children is crucial to assessing the need for pediatric PE response teams in the Netherlands.

Objectives: To evaluate the incidence, management, and short-term outcomes of severe PE in Dutch pediatric patients.

Collagen-elastin dermal scaffolds enhance tissue regeneration and reduce scarring in preclinical models.

Severe scarring is an inevitable consequence of large full-thickness skin wounds, often leading to long-term complications that affect patients' well-being and necessitate extended medical interventions. While autologous split-thickness skin grafts remain the clinical standard for wound treatment, they frequently result in contractures, excessive scarring, and the need for additional corrective procedures. To address these challenges, bioengineered skin substitutes capable of promoting efficient healing while reducing complications are highly desirable.

Physical activity and mortality: towards healthspan-oriented metrics and outcomes. A Scientific Statement from the European Association of Preventive Cardiology (EAPC) of the ESC.

The current guidelines for cardiovascular disease prevention by the European Society of Cardiology highlight the undisputable benefits of exercise and a physically active lifestyle for cardiovascular risk reduction. In addition to the health benefits of physical activity, observational data suggests that regular physical activity lowers all-cause mortality. However, this was not confirmed by Mendelian randomization studies and randomized controlled trials.

A 3-month clofazimine-rifapentine-containing regimen for drug-susceptible tuberculosis versus standard of care (Clo-Fast): a randomised, open-label, phase 2c clinical trial.

Background: Based on results from preclinical and clinical studies, a five-drug combination of isoniazid, rifapentine, pyrazinamide, ethambutol, and clofazimine was identified with treatment shortening potential for drug-susceptible tuberculosis; the Clo-Fast trial aimed to determine the efficacy and safety of this regimen. We compared 3 months of isoniazid, rifapentine, pyrazinamide, ethambutol, and clofazimine, administered with a clofazimine loading dose, to the standard 6 month regimen of isoniazid, rifampicin, pyrazinamide, and ethambutol in drug-susceptible tuberculosis.

Methods: Clo-Fast was a phase 2c open-label trial recruiting participants at six sites in five countries.

Viscoelastic testing in patients with very rare bleeding disorders of secondary hemostasis, a scoping review.

Introduction: Very rare bleeding disorders (VRBDs) are hereditary disorders which cause increased risk of bleeding. In general, VRBDs consists of rare platelet function disorders, very rare coagulation factor deficiencies (other than Factor (F) VIII or FIX) and disorders of the fibrinolytic pathway. The rarity of these disorders along with the scarcity of specialized hemostasis laboratories capable to perform the necessary diagnostic tests, results in significant challenges in diagnosing and monitoring patients with VRBD.

Diagnostic reference level curves for paediatric fluoroscopic imaging in the Netherlands.

Objectives: Establishing paediatric DRLs is challenging due to sparse data availability. The objective was to assess paediatric fluoroscopic dose levels in Dutch clinical practice, as current diagnostic reference levels (DRLs) need updating following the European Guidelines on DRLs for Paediatric Imaging (PiDRL).

Material And Methods: Air Kerma-area Product (KAP) values were retrospectively collected from paediatric patients (0-18 years) who underwent fluoroscopic procedures in nine Dutch hospitals between 01-01-2017 and 01-06-2021.

The European Reference Network eUROGEN, an interview by the Journal of Pediatric Urology.

The European Reference Networks (ERNs) initiative was started by the European Commission. The initiative was launched in 2017 in response to the 2011 EU Directive on Cross-Border Healthcare (Directive 2011/24/EU), which emphasized the need to improve healthcare for patients with rare diseases and complex conditions across the European Union. Currently, 24 ERNs are available for rare diseases.

Multiple maternal occupational exposures during pregnancy and intrauterine growth: analysis of the French Longitudinal Study of Children - ELFE cohort, using data-driven approaches.

Objective: To use data-driven approaches to investigate maternal multi-occupational exposures during pregnancy and their effects on intrauterine growth.

Methods: Maternal occupational exposure to 47 factors during pregnancy was evaluated with job-exposure matrices in the French ELFE cohort. The outcomes of interest were birthweight (BW), small for gestational age (SGA) and head circumference (HC).

The effect of human bone morphology on sawing forces.

In orthopaedic surgical procedures, bone cutting is often performed with an oscillating saw. Achieving an optimal cut requires high accuracy, low temperature, minimal surgeon effort, and time efficiency, all of which may be influenced by the forces applied on the sawing device, and the microstructure of the cut bone. The relation between bovine bone microstructure and sawing forces has been studied.

Exploring touch-colour associations in achromatopsia: A case study.

Crossmodal correspondences - systematic mappings between stimulus attributes in different modalities - are ubiquitous in the general population. For example, high-pitched (vs low-pitched) sounds are commonly associated with elevated (vs low) positions in space, and rounded (vs angular) shapes tend to be linked to the term 'Bouba' (vs 'Kiki'). There is still some debate about the role of immediate sensory experience versus conceptual colour understanding in crossmodal correspondences.