Fit accuracy of complete crowns fabricated by generative artificial intelligence design: a comparative clinical study.

Purpose: Designing restorations remains challenging because the process is time-consuming and requires operator skill and experience. This clinical study evaluated the fit accuracy of polymerized complete crowns fabricated using a web-based 3D generative artificial intelligence design (GAID) method compared to crowns fabricated using a conventional computer-aided design (CCAD) method.

Materials And Methods: Sixty-two patients requiring complete crowns in maxillary and mandibular premolars and molars were enrolled.

Chronically Stable, High-Resolution Micro-Electrocorticographic Brain-Computer Interfaces for Real-Time Motor Decoding.

Brain-computer interfaces (BCIs) enable communication between individuals and computers or other assistive devices by decoding brain activity, thereby reconstructing speech and motor functions for patients with neurological disorders. This study presents a high-resolution micro-electrocorticography (µECoG) BCI based on a flexible, high-density µECoG electrode array, capable of chronically stable and real-time motor decoding. Leveraging micro-nano manufacturing technology, the µECoG BCI achieves a 64-fold increase in electrode density compared to conventional clinical electrode arrays, enhancing spatial resolution while featuring scalability.

Systematic review and evidence gap mapping of Alzheimer's disease biomarker studies in those with intellectual and developmental disability.

Unlabelled: There are a relatively small number of investigations into brain aging in those with intellectual and developmental disability (I/DD). This project seeks to (1) characterize the internationally available multi-omics Alzheimer's disease (AD) biomarker studies including those with I/DD, and (2) discuss future research directions. PubMed, Web of Science, and Scopus were searched under the following criteria: cross-sectional or longitudinal AD-omics studies on adults (18 +) with I/DD.

The CROCO (CROhn's Disease COhort Study) - study design and protocol.

Background: Crohn's disease (CD) is a chronic, relapsing and remitting inflammatory bowel disease that can be associated with significant bowel damage and disability. The Lémann Index (LI) is a validated tool for measuring cumulative bowel damage in CD patients through a comprehensive assessment of stricturing, penetrating and surgical lesions. However, prospective studies evaluating bowel damage progression in recently diagnosed CD patients remain limited.

White Matter Tract Vulnerability to Amyloid Pathology on the Alzheimer's Disease Continuum.

Alzheimer's disease (AD) is marked by progressive cognitive decline and memory loss, due to the abnormal accumulation of amyloid-beta () plaques, followed by tau pathology, and a gradually spreading pattern of neuronal loss. Understanding how amyloid positivity affects the brain's neural pathways is critical for understanding how the brain changes with AD pathology. Tractometry offers a powerful approach for the , 3D quantitative assessment of white matter tracts, enabling the localization of microstructural abnormalities in diseased populations and those at risk.

Safety of tralokinumab in patients with moderate-to-severe atopic dermatitis followed for up to 4.5 years: an integrated analysis of 8 clinical trials.

Background: Patients with moderate-to-severe atopic dermatitis (AD) require long-term management, and understanding the long-term safety of new treatments is a top priority for patients and healthcare professionals.

Objectives: To evaluate the safety of tralokinumab in adults and adolescents with moderate-to-severe AD by conducting an integrated safety analysis of 7 placebo-controlled trials and the ongoing, open-label extension study ECZTEND.

Methods: An initial 16-week placebo-controlled (PBO-CTRL) safety set and an all-tralokinumab (ALL-TRALO) safety set combining the placebo-controlled trials and ECZTEND (data cut-off 30 April, 2022) were analyzed.

[Lung and systemic sclerosis].

Interstitial lung disease (ILD) is a frequent and potentially life-threatening complication of systemic sclerosis, affecting 40 to 50% of patients. Systematic screening with high-resolution computed tomography and pulmonary function tests (PFTs), including DLCO, is recommended at diagnosis. ILD may be present even in patients with normal PFTs.

High-Precision, Low-Threshold Neuromodulation With Ultraflexible Electrode Arrays for Brain-to-Brain Interfaces.

Neuromodulation is crucial for advancing neuroscience and treating neurological disorders. However, traditional methods using rigid electrodes have been limited by large stimulating currents, low precision, and the risk of tissue damage. In this work, we developed a biocompatible ultraflexible electrode array that allows for both neural recording of spike firings and low-threshold, high-precision stimulation for neuromodulation.

The risk of delirium or dementia-related hospitalization among individuals living with dementia after long-term care entry: A population-based risk prediction model.

Introduction: Identifying individuals with dementia in long-term care facilities (LTCFs) at risk for delirium or dementia-related hospitalizations can support individualized risk mitigation.

Methods: Using the Registry of Senior Australians (ROSA) Historical National Cohort (N = 207343 individuals with dementia in 2655 LTCFs), we identified predictors of delirium or dementia-related hospitalization within 365 days of LTCF entry and developed a risk prediction model using elastic net penalized regression and Fine-Gray model. Model discrimination using area under the receiver operating characteristics curve (AUC), calibration and clinical utility were assessed.

Real-world comparison of the effectiveness of tofacitinib and ustekinumab in patients with ulcerative colitis: the TORUS study.

Background And Aims: We compared the effectiveness of tofacitinib and ustekinumab in patients with ulcerative colitis (UC) previously exposed to at least one anti-TNF agent.

Methods: In this multicenter real-world evidence study, we consecutively included UC patients ≥18 years-old, previously exposed to anti-TNF therapy, with partial Mayo score >2 and, starting tofacitinib or ustekinumab. All the comparisons were performed using propensity score analyses.

Sex differences in the association of cardiometabolic risk scores and blood pressure measurements with white matter hyperintensities in diverse older adults-HABS-HD.

Introduction: We aimed to determine whether cardiometabolic risk factors and blood-pressure (BP) metrics were differentially associated with white matter hyperintensities volume (WMHV) in males versus females in the Health and Aging Brain Study-Health Disparities.

Methods: We analyzed 3,585 community-dwelling adults (2,207 females) from non-Hispanic White, non-Hispanic Black, and Hispanic groups who underwent BP measurement and WMHV quantification. Linear regression models assessed (i) individual risk factors (diabetes, hypertension, dyslipidemia, obesity, tobacco dependence), (ii) a composite risk score, and (iii) four BP metrics (systolic, diastolic, pulse pressure, mean arterial pressure), each including a sex-interaction term and adjusting for age, education, race/ethnicity, and scanner.

Physical and Psychosocial Frailty Indicators as Predictors of Oral Frailty in Community-Dwelling Older Women.

Objectives: With the growing older population, oral and general frailty have increased. This study aims to examine the association and predictive role of physical and psychosocial frailty indicators in oral frailty among older Korean women.

Methods: In total, 334 women aged 65 years or older participated in the 2017 health survey of the Korean Social Life, Health, and Aging Project on Ganghwa Island, Korea.

Optimizing timing and cost-effective use of plasma biomarkers in Alzheimer's disease.

Background And Objectives: Early and cost-effective identification of amyloid positivity is crucial for Alzheimer's disease (AD) diagnosis. While amyloid PET is the gold standard, plasma biomarkers such as phosphorylated tau 217 (pTau217) provide a potential alternative. This study evaluates the diagnostic accuracy of a combined-panel approach using machine learning models and evaluated the biomarker significance.

Long-Term Nutritional Status in Children Born With Esophageal Atresia.

Background And Objectives: Previous studies have reported early undernutrition and growth delay in children born with esophageal atresia (EA). Our goal was to assess their long-term nutritional status.

Methods: We longitudinally studied 204 children born with EA (91% with tracheoesophageal fistula) from birth to 16 years.

The association of organophosphate flame retardants (OPFRs) exposure on omega-3 fatty acids metabolism: evidence derived from the United States general population.

This study investigated the association between exposure to organophosphate flame retardants (OPFRs) and serum omega-3 fatty acid levels in the general U.S. population, using data from 1,350 adults in the 2011-2014 National Health and Nutrition Examination Survey (NHANES).

Ingestion of environmentally sourced polyvinyl chloride microplastic fragments increases colon inflammation and fibrosis in mice.

Plastics released into the environment inevitably degrade into microplastics, which subsequently enter the food web. As a result, humans are chronically exposed to microplastics through ingestion. However, studies evaluating the effects of environmentally derived microplastics are limited.

Combined Deletion of Mitofusin 2 in Adipose-Mesenchymal Derived Stem Cells and Melatonin Offers Additional Benefits on Protecting the Brain Against Acute Ischemic Stroke in Rat.

Ischemic stroke (IS) remains the third leading cause of death, and the treatment of acute ischemic stroke (AIS) is still a formidable challenge to clinicians. This study tested the hypothesis that combined silencing Mnf2 gene in adipose-derived mesenchymal stem cells (ADMSCs) and melatonin (Mel) therapy was superior to monotherapy on attenuating the brain infarct volume (BIV) and improving neurological function in AIS rats. and studies were conducted.

Health and Aging Brain Study-Health Disparities (HABS-HD) methods and partner characteristics.

Introduction: The Health and Aging Brain Study-Health Disparities (HABS-HD) is an ongoing prospective study aimed at understanding brain health and aging. The current work provides a description of the cohort baseline characteristics and outlines the study methodology.

Methods: We analyzed available data from  = 1066 non-Hispanic Black (NHB),  = 1425 Hispanic, and  = 1349 non-Hispanic White (NHW) partners who were actively enrolled in HABS-HD.

Prognosis of pediatric-onset inflammatory bowel disease associated with primary sclerosing cholangitis: A population-based study.

Objectives: To assess whether the prognosis of pediatric-onset inflammatory bowel disease (IBD) is influenced by its association with primary sclerosing cholangitis (PSC) considering medical treatment, bowel resection, risk of cancer, and mortality.

Methods: A retrospective population-based study was conducted using data from the EPIMAD Registry, one of the most extensive prospective population-based IBD studies globally. Cases (IBD-PSC) were compared with matched controls (matched-IBD).

Skin Testing for the Exploration of Immediate and Delayed Hypersensitivity to Fluoroquinolones: Insights From a Real-Life Cohort Study.

Fluoroquinolones (FQ) are the second most frequent antibiotics responsible for hypersensitivity reaction (HSR). Data concerning the interest of allergological work-ups are scarce. We reported a university center experience of the interest and safety of skin tests (ST) and drug provocation tests (DPT) for the exploration of immediate hypersensitivity reaction (IHR) and delayed HSR (DHR) to FQ.

Nanog overexpression enhances the therapeutic efficacy of ADMSCs in AMI rats via the upregulation of JAK/STAT3 signaling and cyclin-mitochondrial expression.

This study investigated whether Nanog-overexpressing adipose-derived mesenchymal stem cells (Nanog-ADMSCs) are superior to unmodified ADMSCs in improving the left ventricular ejection fraction (LEVF) in acute myocardial infarction (AMI) patients. We utilized silencing and overexpression of Nanog gene in ADMSCs and performed a wound healing assay/transwell migration assay/MTT cell viability assay/left coronary artery ligation for AMI induction. Additionally, we categorized the cells into three classes [i.

The role of UPR-related long noncoding RNAs in development of endocrine resistance in breast cancer.

Breast cancer patients who express estrogen receptor α (ER) typically receive endocrine therapy as a first-line treatment. Most ER-positive breast cancer patients initially respond to endocrine therapy, but up to 40% of patients develop resistance over time, and the main mechanism is aberrant activation of ER signaling pathways. Recent research has shown that cancer's uncontrolled proliferative capacity and a hostile microenvironment can induce endoplasmic reticulum (EnR) stress and trigger unfolded protein response (UPR), which plays a crucial role in determining cell fate.