PD-L1 expression in locally advanced cervical cancer: A pilot cross clone comparison study.

Purpose: Recent immunotherapy trials in locally advanced cervical cancer report high PD-L1 positivity rates whereas academic multicentric initiatives report a lower PD-L1 positivity. These observations necessitate cross-clone comparison to understand the observed differences.

Methods: Two different clones used in previous multicentric international studies SP142 (BIOEMBRACE) and 22C3 (KEYNOTE-A18) were used to test PD-L1 positivity in a pilot cohort of FIGO 2018 stage III cervical cancer patients recruited in a phase III trial.

Effective nutritional intervention improves the health-related quality of life (HRQL) of undernourished children with cancer: results of a randomized, controlled phase 3 trial.

Purpose: The association of nutritional intervention and health-related quality of life (HRQL) was examined in children with cancer.

Methods: Undernourished children with cancer (N = 260) were randomized 1:1 to standard nutritional therapy (SNT) or SNT + Ready to Use Therapeutic Food (RUTF). HRQL was assessed using the Health Utilities Index® (HUI) at study entry and 6 weeks later.

Clathrin-Mediated Endocytosis for Enhanced Apoptosis Induction and Cellular Imaging in Triple-Negative Breast Cancer by Casein-Protected Blue-Emissive Carbon Dots.

The development of multifunctional nanoplatforms capable of drug delivery and real-time cellular imaging remains a key challenge in cancer theranostics. Herein, we report the development of a casein-protected maleic acid-derived nitrogen-doped carbon dot-based luminescent nanoplatform (MNCD@Cas NPs) for efficient delivery of the anticancer drug doxorubicin hydrochloride (DOX) to triple-negative breast cancer cells. Synthesized via a facile two-step method, the MNCD@Cas NPs exhibit bright blue fluorescence (λ = 390 nm), high water dispersibility, excellent colloidal stability, and substantial DOX loading capacity (∼84%) driven by electrostatic interactions.

Manganese-Catalyzed Synthesis of γ-Hydroxy Phosphine Oxides by Addition of Phosphine Oxides to Allylic Alcohols.

A manganese(II)-catalyzed anti-Markovnikov addition of diarylphosphine oxides to primary and secondary allylic alcohols has been developed, which delivered synthetically valuable γ-hydroxy phosphine oxides. The reaction proceeds under mild, base-assisted conditions with a broad substrate scope and excellent functional group tolerance. Mechanistic studies indicate the involvement of a homogeneous catalytic system and a radical pathway.

The Hypoxia-Induced Chromatin Reader ZMYND8 Drives HIF-Dependent Metabolic Rewiring in Breast Cancer.

Breast cancer, a leading cause of mortality, exhibits significant heterogeneity across molecular subtypes, with tumor hypoxia contributing to poor therapeutic outcomes. The present study investigates the role of ZMYND8, a hypoxia-responsive epigenetic factor, in regulating carbohydrate metabolism in concert with HIF1α in breast cancer. In adherent cells as well as in 3D MCTS, ZMYND8 expression is elevated under hypoxic conditions.

Copper-Catalyzed Selective 1,2-Reduction of Quinolines.

Selective reduction of heteroaromatic compounds to partially hydrogenated, dearomatized molecules is a tantalizing task. A well-defined, air stable, and pyridine-based Cu(II) NNN pincer complex is developed, which catalyzes selective 1,2-reduction of quinolines. The unstable 1,2-hydrogenated quinolines are transformed into the corresponding amides and isolated in good yields.

Six Hundred and Sixty Nanometer Light Exposure-Induced Alterations in Actin Filament, Mitochondrial Morphological Dynamics, and Migration in Mesenchymal Stem Cells.

Actin cytoskeleton alteration and cell homing/migration are crucial determinants for the success of stem cell (SC) based therapy. Photobiomodulation (PBM) is a promising non-pharmacological approach for modulating SC potency. Though ~660 nm is the most studied wavelength for the proliferation/differentiation of SCs, the migration and cytoskeleton remodeling aspects have not been investigated in detail.

A traditional Cameroonian spice, Syzygium guineense curtails leukemia tumor growth through G2-M cell cycle arrest and predicted NLRP3 inflammasome pathway.

Background: S. guineense DC. var.

Targeting mitochondrial proteases CLPP and LONP1 via disruption of mitochondrial redox homeostasis induces proteotoxic stress and suppresses tumor progression.

Background: Cancer cells, which rely heavily on mitochondria for their energy demands and oncometabolites, have a high mitochondrial load, often associated with an aggressive, invasive, and metastatic phenotype. Mitochondrial ROS (mtROS), which play a causal role in cancer, represent the Achilles' heel of cancer since excessive mtROS causes protein misfolding/aggregation, resulting in cell death via proteotoxic stress. Furthermore, the detailed underlying mechanism(s) of mitochondrial oxidative stress-induced cell death remain obscure.

Diffuse Cutaneous Angiosarcoma Involving Scalp and Face on 18F-FDG and 68Ga-NODAGA-RGD PET/CT.

Cutaneous angiosarcoma of the scalp is a rare, highly aggressive malignant tumor. A 67-year-old man with initial presentation of intermittent facial puffiness, periorbital swelling, and a gradually increasing painless ulcerative lesion on the right side of his forehead, and biopsy-proven cutaneous angiosarcoma, underwent 18F-FDG-PET/CT for initial staging. FDG-PET/CT demonstrated increased tracer uptake in the scalp and facial regions, encompassing periorbital and perinasal areas.

Treatment approaches for non-metastatic small cell bladder cancer: a meta-analysis of reconstructed Kaplan-Meier curves.

Introduction: Small cell bladder cancer is an aggressive histological subtype and represents one of the most common extra-pulmonary small cell carcinomas. Treatment options include radical cystectomy, chemotherapy, radiotherapy, or combinations of these three. However, the optimal treatment approach remains unknown.

Amyloid formation of mutated Alzheimer's Aβ 16-36 residues peptide and application in toxic lead and uranium ion binding.

Amyloid nanostructures are gaining attention as bio-compatible materials with diverse potential applications. The formation/self-assembly of amyloid fibrils, though implicated in the prognosis of several neurodegenerative diseases, contrastingly can also be explored for their functional properties owing to their unique stability and strength. The physicochemical environment and amino-acid composition are characteristic and specifically crucial for a protein/peptide to form amyloid fibrils.

Lymph Node Mapping in Gallbladder Cancers: Analysis to Assess the Impact of Location and Number of Lymph Nodal Stations.

Background And Objectives: The current staging for gallbladder cancer (GBC) considers only the number of metastatic lymph nodes without addressing their location. This study evaluates the prognostic impact of lymph node mapping (both number and location) in node positive GBC.

Methods: Prospectively maintained operative database of operated GBC patients from April 2010 to March 2022 with positive lymph nodes was analyzed.

The Hik2-Rre1 interaction acts as a two-component signaling system in filamentous cyanobacterium Anabaena PCC 7120.

Photosynthetic organisms often rely on two-component regulatory system to adapt to environmental changes. This system is crucial for connecting external signals with the response mechanism by controlling gene expression, eventually allowing the organism to acclimatize to various stresses. Cyanobacteria, in particular, possess a large number of these two-component systems.

Primary Yolk Sac Tumor of the Stomach in a 2-Year-Old Boy: Case Report on a Rare Site for Extragonadal Malignant Germ Cell Tumor.

Up to one-third of germ cell tumors are extragonadal neoplasms, with yolk sac tumors (YSTs) being the most common malignant histology. This report describes the successful multimodal management of a primary YST of the stomach in a 2-year-old boy. The child presented with melena, and further evaluation revealed a mass lesion in the cardia of the stomach.

Clinical Success Impacts Overall Survival in Patients Undergoing Palliation for Malignant Gastric Outlet Obstruction Using Enteral Stents or Endoscopic Ultrasound Guided Gastroenterostomy.

Background: EUS-guided gastroenterostomy (EUS-GE) and enteral stents (ES) are minimally invasive options for managing malignant gastric outlet obstruction (mGOO). We aimed to compare EUS-GE with ES with respect to clinical success assessed objectively and overall survival.

Methods: Retrospective review of patients > 18 years who underwent either ES or EUS-GE for palliation of mGOO between January 2021 and January 2024 was done.

Exploring the multifaceted applications of antimony(III/V) corrole complexes.

Tetrapyrrolic macrocycles coordinated to redox-active main-group elements, particularly from groups 14 and 15, have emerged as efficient photocatalysts for substrate oxidation under ambient conditions. Among group 15 elements, antimony commonly adopts +III and +V oxidation states and forms stable high-valent complexes with porphyrinoid ligands such as corroles, which readily accommodate diverse axial ligands (, O-, N-, and S-donors). Antimony corrole complexes exhibit considerable promise across diverse fields, including catalysis, biomedicine, and advanced dielectric and optoelectronic applications.

Achieving Deep Red Emission in Mn-Activated KMgGeO Phosphor with a Tetrahedral Network for Light-Emitting Diodes.

Designing a thermally robust Mn-based red-emitting phosphor is essential for warm phosphor-converted light-emitting diodes (pc-LEDs) with improved CRI and indoor plant cultivation applications. However, the major constraint is selecting a host with octahedral crystallographic sites and poor thermal stability. Herein, we report the stabilization of Mn ions in tetrahedral coordination in a KMgGeO matrix.

High performance bilayer 2D VO cathode for Zn-ion and Zn/Li hybrid metal-ion intercalation battery.

The deteriorating and unevenly distributed Li reserves lead to the quest for Li-ion battery's alternatives.Hybrid metal-ion batteries are gaining attention as they effectively address the limited diffusion of heavier ions into cathode materials, typically involving the combination of multi and mono-valent metal-ions.The unavailability of high-performance cathode materials restricts the use of heavier ion (e.

Evolving Treatment Paradigms in Metastatic Hormone-Sensitive Prostate Cancer: Expert Narrative Review.

The treatment landscape of metastatic hormone-sensitive prostate cancer (mHSPC) has transformed significantly with the advent of triplet therapy involving androgen deprivation therapy (ADT), docetaxel, and androgen receptor signalling inhibitors (ARSIs). While clinical guidelines increasingly support early intensification, real-world practice remains challenged by patient heterogeneity, evolving evidence, and limited consensus on treatment sequencing. This narrative review integrates evidence from landmark trials, clinical guidelines, and expert insights from oncologists managing mHSPC in India.

Evaluation of clinical research priorities in Asian intensive care units (ERA-ICU).

Background: Practice and delivery of critical care in Asia varies according to healthcare structure, income setting, and cultural factors. Identifying research priorities specific to ICU patients and healthcare workers in Asia is needed to guide advancement of critical care in the region.

Methods: This was an international cross-sectional survey study with adapted methods from nominal group techniques.

Search for a Neutral Gauge Boson with Nonuniversal Fermion Couplings in Vector Boson Fusion Processes in Proton-Proton Collisions at sqrt[s]=13 TeV.

The first search for a heavy neutral spin-1 gauge boson (Z^{'}) with nonuniversal fermion couplings produced via vector boson fusion processes and decaying to tau leptons or W bosons is presented. The analysis is performed using LHC data at sqrt[s]=13  TeV, collected from 2016 to 2018 with the CMS experiment and corresponding to an integrated luminosity of 138  fb^{-1}. The data are consistent with the standard model predictions.

Prevalence and Associated Factors of Cognitive Dysfunction Among Middle-Aged Type 2 Diabetes Mellitus Patients in South India: A Cross-Sectional Study.

Introduction Cognitive dysfunction significantly influences people's day-to-day functioning by impairing their capacity for thought, memory, and problem-solving. The major risk factor for cognitive dysfunction is diabetes mellitus. The middle-aged population is the main breadwinners of the family, yet the most neglected when it comes to health.