Achieving Deep Red Emission in Mn-Activated KMgGeO Phosphor with a Tetrahedral Network for Light-Emitting Diodes.

Designing a thermally robust Mn-based red-emitting phosphor is essential for warm phosphor-converted light-emitting diodes (pc-LEDs) with improved CRI and indoor plant cultivation applications. However, the major constraint is selecting a host with octahedral crystallographic sites and poor thermal stability. Herein, we report the stabilization of Mn ions in tetrahedral coordination in a KMgGeO matrix.

Design, synthesis, anti-breast cancer and studies of substituted triphenyl imidazole-alkyl linked indole derivatives.

Aim: Cancer is an affliction on societies worldwide, chemotherapy, though effective, has its limitations, indicating the need for new therapeutic agents. Imidazole and indole are two important bioactive heterocycles important for developing newer anticancer molecules.We synthesized a series of substituted imidazole-linked indole derivatives and evaluated them for anticancer activity on MCF-7 cells.

Electronic Structure Modulation of AlN Single-Atom Catalyst for Oxygen Reduction Reaction.

Mechanistic origins of oxygen reduction reaction (ORR) in p-block metal-based single-atom catalysts (SACs) remain underexplored. Aluminium (Al) typically hinders catalytic activity due to strong binding with oxygenated intermediates, limiting its effectiveness for ORR. However, tailoring electronic structure and coordination environment around Al atoms can optimize the p-band center that may enhance catalytic activity.

Bioinspired Synthesis of Intrinsically Radiolabeled DyO Nanoparticles as an In Vivo Generator of Dy/Ho: A Smart Choice for Theranostics Engineering.

Functionalized inorganic nanoparticles (NPs) intrinsically radiolabeled with theranostic radiometals hold the potential to revolutionize cancer management. The appropriate choice of the radiometal used in the nanoplatform would not only aid in the diagnosis and staging of the disease but also facilitate them becoming an integral part of the therapeutic regimen, either as an independent treatment or in combination with other conventional modalities. Furthermore, due to the inherent characteristics of the NPs, such systems can demonstrate potential in multimodality imaging to offer improved diagnostic and therapeutic monitoring abilities for personalized treatment.

In Vitro Study of Vitamin D Effects on Immune, Endothelial, and Vascular Smooth Muscle Cells in Chronic Kidney Disease.

Vitamin D has been shown to improve immunity as well as vascular function. We investigated the effect of cholecalciferol on T-cell phenotype in cultured peripheral blood mononuclear cells (PBMCs) from twenty vitamin D-deficient, non-diabetic chronic kidney disease (CKD) subjects. We also studied vitamin D effects on endothelial and vascular function markers in human aortic endothelial cells (HAECs) and in human aortic smooth muscle cells (HASMCs), respectively.

Metformin Versus Standard of Care in Patients with Autosomal Dominant Polycystic Kidney Disease - A Randomized Control Trial.

Background: Autosomal dominant kidney disease (ADPKD) is the most common monogenic disorder leading to renal failure with limited therapeutic options. We aimed to assess the efficacy and safety of metformin in nondiabetic ADPKD patients and its role in slowing disease progression.

Materials And Methods: We conducted a prospective, randomized controlled, open labelled clinical trial and enrolled 52 nondiabetic adults aged 18-60 years with typical ADPKD, estimated glomerular filtration rate (eGFR) > 45 mL/min/m, and no risk factors of rapid disease progression.

Effect of cholecalciferol on immune and vascular function in non-diabetic chronic kidney disease.

Background And Aims: Vitamin D deficiency, widely prevalent in patients with chronic kidney disease (CKD) could play a role in the pathogenesis of cardiovascular disease (CVD) by causing alterations in endothelial and immune function. We investigated the change in immune and vascular functions following vitamin D supplementation in non-diabetic subjects with stage 3-4 CKD and vitamin D deficiency.

Methods: In this single-arm study, non-diabetic CKD subjects aged 18-75 years, eGFR 15-60 ml/min/1.

Diagnostic and Prognostic Accuracy of MMPs and TIMPs in Oral Cancer Patients on Enzyme-Linked Immunosorbent Assay (ELISA) as Compared to Immunohistochemistry (IHC).

Oral cancer is one of most common noncommunicable diseases that imposed significant burden on healthcare around the globe including India. Several molecular markers have been extensively researched for their potential as diagnostic and prognostic biomarkers for oral cancer. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) found to play a crucial role in cytoskeleton dynamics and thus tumor growth and metastasis.

Implication of Gut Mycobiome and Virome in Type-2 Diabetes Mellitus: Uncovering the Hidden Players.

Type-2 diabetes mellitus (T2DM) is a global epidemic with significant societal costs. The gut microbiota, including its metabolites, plays a pivotal role in maintaining health, while gut dysbiosis is implicated in several metabolic disorders, including T2DM. Although data exists on the relationship between the gut bacteriome and metabolic disorders, further attention is needed for the mycobiome and virome.

Unleashing the Potential of Defect Engineered Persistent Pr-Activated Phosphors for Multi-Dimensional Anti-Counterfeiting and X-Ray Imaging Applications.

Persistent luminescence (PersL) in inorganic phosphors offers great potential for anti-counterfeiting and optical storage, with optimization of PersL, multicolor tuning, and defect engineering. This study presents a CaGaGeOPr (CGGO:Pr) phosphor with long-lasting PersL and multicolor emissions. Aliovalent codoping with Er and Yb ions optimizes deep/shallow trap redistribution, controlling trap depths from 0.

Assessment of Antimicrobial Potential of Lactiplantibacillus plantarum and Their Derived Extracellular Vesicles.

Scope: Probiotic-derived antimicrobial substances offer a promising treatment approach with less resistance risk. This study evaluated the antimicrobial activity of 20 Lactiplantibacillus plantarum strains of human gut origin and their derived extracellular vesicles (EVs) against the pathogens Staphylococcus aureus MTCC 96 and Propionibacterium acnes MTCC 1950.

Methods And Results: The cell-free supernatants (CFSs) of all Lactobacillus isolates were initially screened for antimicrobial potential against the selected pathogens.

Probiotic Lactobacillus-Derived Extracellular Vesicles: Insights Into Disease Prevention and Management.

Bacterial extracellular vesicles (BEVs) have emerged as versatile and promising tools for therapeutic interventions across a spectrum of medical applications. Among these, Lactobacillus-derived extracellular vesicles (LDEVs) have garnered significant attention due to their diverse physiological functions and applications in health advancement. These LDEVs modulate host cell signaling pathways through the delivery of bioactive molecules, including nucleic acids and proteins.

Role of soluble interleukin-2 receptor (sIL-2R) as a predictor for severe dengue infection.

Annually, around half a million people with severe dengue require hospitalization, all over the globe, with around 12,500 (2.5%) succumbing to the illness. In this prospective observational study, we recruited 74 patients with dengue infection, 28 had severe dengue and 46 had dengue with warning signs.

From nature to applications: Laccase immobilization onto bio-based materials for eco-conscious environmental remediation.

Biodegradable and sustainable materials utilized for laccase immobilization have garnered substantial scholarly interest owing to their capacity to enhance enzyme stability and reusability, which are paramount for effective bioremediation methodologies. Laccase, a versatile oxidase, possesses the ability to degrade a broad spectrum of environmental contaminants, thus rendering it an invaluable asset in bioremediation endeavours. The immobilization of laccase onto biodegradable substrates not only augments its operational stability but also resonates with sustainable environmental strategies.

Development and Validation of an Accurate Creatinine-Based Equation to Estimate Glomerular Filtration Rate for the Adult Indian Population: Design and Methods.

Background: Existing creatinine-based equations to estimate glomerular filtration rate (GFR), developed primarily in populations of European and African American ancestry, do not accurately reflect the GFR in the Indian population due to differences in body composition, diet, and other factors. This manuscript describes the rationale and methodology for developing a creatinine-based equation for more accurate GFR estimation in Indian subjects.

Materials And Methods: This cross-sectional study will be conducted in India's two geographically and demographically diverse locations: Chandigarh (north) and Puducherry (south).

Microbial amidases: Characterization, advances and biotechnological applications.

The amidases (EC 3.5.1.

Broadband Shortwave Infrared-Emitting Cr- and Ni-Codoped YAlGaO Phosphor with Excellent Thermal Stability for Multifunctional Applications.

Shortwave infrared (SWIR)-emitting materials have emerged as superior light sources with increasing demand for potential applications in noninvasive analysis, night vision illumination, and medical diagnosis. For developing next-generation SWIR phosphor-converted light-emitting diodes (pc-LEDs), the scarcity of intense blue-light-pumped broadband SWIR luminescent materials and poor thermal stability of current Ni-activated phosphors are the ongoing challenges. Here, a blue-light-excitable (440 nm) YAlGaO:Cr,Ni phosphor with ultrawide SWIR emission centered at ∼1430 nm (FWHM ∼264 nm) is reported.

Evaluation of Race-Neutral Glomerular Filtration Rate Estimating Equations in an Indian Population.

Introduction: Glomerular filtration rate (GFR) estimation equations have not been extensively validated in the Indian population. Preliminary data showed that the widely used creatinine-based Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) 2009 significantly overestimated GFR in Indians. Newer estimated GFR (eGFR) equations based on creatinine and cystatin C, omitting the race, have been recently proposed.

Design, synthesis, biological evaluations and in silico studies of (Z)-2-(2,4-dioxothiazolidin-5-ylidene)methyl)-2-ethoxyphenyl-alkyl/arylsulfonates as potential α-glucosidase inhibitors.

Diabetes mellitus is considered one of the major worldwide health emergencies of the twenty-first century. This work described development, synthesis, and characterization of new (Z)-2-(2,4-dioxothiazolidin-5-ylidene)methyl)-2-ethoxyphenyl-alkyl/aryl-sulfonates. Compounds 7j and 7m were shown to be the most potent among the newly developed (Z)-2-(2,4-dioxothiazolidin-5-ylidene)methyl)-2-ethoxyphenyl-alkyl/aryl-sulfonates after in vitro testing for α-glucosidase inhibitory activity.

Carbon dot-graphene oxide-based luminescent nanosensor for creatinine detection in human urine.

A fluorescence (FL)-based nanosensor has been devised for creatinine (CR) detection in human urine specimens. The proposed nanosensor utilized a nanocomposite (NC) of carbon dots (CDs) and graphene oxide (GO). The formation of CDs/GO NC reduced the CD FL emission (λ = 390 nm, λ = 461 nm) by ~ 75%.

Near-IR nanolignin sensitizers based on pyrene-conjugated chlorin and bacteriochlorin for ROS generation, DNA intercalation and bioimaging.

Near-infrared (NIR) fluorescent agents are extensively used for biomedical imaging due to their ability for deep tissue penetration. Tetrapyrrole-based photosensitizers are promising candidates in this regard. Further, the extended conjugation of such macromolecules with chromophores can enhance their fluorescence efficiency and DNA intercalation ability.

Recycling waste tires into sustainable biofuel for replacing petroleum fuel in diesel engines using nanoparticles and biohydrogen.

In this paper, the production of pyrolyzed oil in lab scale plant and its possible use in variable speed diesel engine with nanoparticle and secondary fuel oxy-hydrogen gas is investigated. The pyrolyzed oil is produced from waste tires in lab scale plant, and after its distillation, it is blended with neat diesel in the proportion of 20:80 (TDF). The different testing fuels are prepared by mixing nanoparticle CeO (NP) at the concentrations 50 ppm and 100 ppm with blended fuel (named as TDF-NP50 and TDF-NP100).

Hydrophobic assembly of molecular catalysts at the gas-liquid-solid interface drives highly selective CO electromethanation.

Molecular catalysts offer tunable active and peripheral sites, rendering them ideal model systems to explore fundamental concepts in catalysis. However, hydrophobic designs are often regarded as detrimental for dissolution in aqueous electrolytes. Here we show that established cobalt terpyridine catalysts modified with hydrophobic perfluorinated alkyl side chains can assemble at the gas-liquid-solid interfaces on a gas diffusion electrode.