Grafting of Resveratrol-Chitosan Nanoparticles as a Promising Radiosensitizer and Protector in DMBA-Induced Breast Cancer in Mice.

Introduction: Breast cancer is the most common malignancy among women and the second leading cause of cancer-related deaths worldwide. Resveratrol, a polyphenolic stilbene derivative found in grapes, red wine, and other plants, possesses anti-cancer properties. Various studies have reported the potential of different nanomaterials to act as radiosensitizers against tumor cells.

Exploring biocontrol strategies for Phytopathogens using plant growth-promoting rhizobacteria-derived enzymes: A review of current advances and future directions.

The growing demand for sustainable agriculture imposes innovative biocontrol strategies to mitigate phytopathogen threats while reducing dependence on chemical pesticides. This review explores the current knowledge on enzyme-based biocontrol, focusing on hydrolytic enzymes (e.g.

Poly glycerol sebacate/poly lactide acid (PGS/PLA) hydrogel in combination with hyperbaric oxygen therapy improved full thickness wound healing in diabetic rat.

Chronic wounds, particularly in diabetic patients, pose significant therapeutic challenges due to impaired healing under ischemic conditions. This study investigated the synergistic effect of a poly glycerol sebacate/poly lactide acid (PGS/PLA) hydrogel combined with hyperbaric oxygen therapy (HBOT) on wound healing in a diabetic rat model. Full-thickness skin wounds were induced on the dorsum of rats and treated with PGS/PLA, HBOT, or their combination.

Phyto-assisted synthesized CuO NPs embedded in crosslinked zein/alginate composite films for hastening wound healing and tissue regeneration in rats bio-template.

Biopolymer-based composite films were primed by incorporating alginate and zein natural polymers using a solution-casting method and superbly assisted by eco-friendly prepared copper oxide nanoparticles (CuO NPs). The influence of the addition method of CaCl as a crosslinker and CuO NPs loading content (0.1, 0.

The Differences in the Evolutionary Dynamics of MERS and SARS Coronaviruses.

SARS-CoV and MERS-CoV are two coronaviruses that have received significant attention due to their high pathogenicity and mortality rates in human populations. In this study, we compared their evolutionary dynamics to provide a One Health perspective on their differences in terms of the results of disease control. The phylogenetic network of SARS-CoVs showed that human isolates gathered into a "super-spreader" cluster and were distinct from civet isolates.

New Neonatal and Prenatal Approach to Home Therapy with Amoxicillin, Rifaximin, and Anti-Inflammatory Drugs for Pregnant Women with COVID-19 Infections-Monitoring of Fetal Growth as a Prognostic Factor: A Triple Case Series (N.A.T.H.A.N.).

Since the COVID-19 pandemic, managing acute infections in symptomatic individuals, regardless of vaccination status, has been widely debated and extensively studied. Even more concerning, however, is the impact of COVID-19 on pregnant women-especially its effects on fetuses and newborns. Several studies have documented complications in both expectant mothers and their infants following infection.

Antioxidant Capacity and Therapeutic Applications of Honey: Health Benefits, Antimicrobial Activity and Food Processing Roles.

Honey is a natural product of honeybees that has been consumed for centuries due to its nutritional value and potential health benefits. Recent scientific research has focused on its antioxidant capacity, which is linked to a variety of bioactive compounds such as phenolic acids, enzymes (e.g.

Laboratory performance of novel injectable keratin nanoparticle from poultry feathers loaded-alginate composite hydrogel as a pulpotomy filling biomaterial for dentin regeneration.

Background: Various medicaments have been utilized as an aid for wound healing following vital pulp treatment. Many of them are synthetic in origin and have disadvantages as limited amount of cytotoxicity and great expense. Hence, to tackle these drawbacks, naturally derived blended scaffolds have been employed in renovative dental field.

In-depth investigation the size effect of zinc oxide nanostructures on the photodegradation of different dyes under UV-irradiation: anticancer application.

The aim of this research was to prepare a different particle sizes of zinc oxide nanostructures by two different methods. The zinc oxide nanoparticle (ZnO NP) was successfully prepared by a green synthesis technique but the zinc oxide quantum dot (ZnO QD) was successfully prepared by a chemical method. The structure, composition and morphology of the prepared different shapes of ZnO nanostructures have been characterized by the means of X-ray diffractograms (XRD), high resolution transmission electron microscope (HRTEM), Energy Dispersive x-ray (EDX), UV-Vis spectroscopy and Fourier transform infrared spectroscopy (FTIR).

cfDNA Key genomic markers in HCV-Induced hepatocellular carcinoma in Egyptian patients.

Background: Malignant liver disease is among the highest in the world, with hepatocellular carcinoma (HCC) accounting for up to 90 % of all cases. In Egypt, HCC poses a significant public-health concern, representing 47.17 % of cancer cases.

Prebiotic properties and antioxidant effect of crude extracts and polysaccharides from Agaricus bisporus and Pleurotus ostreatus mushrooms.

Modifying the gut microbiome, also known as bacteriotherapy, is a key strategy that uses probiotics, prebiotics, or synbiotics to reduce inflammation and fight infection and colonization by pathogenic bacteria. Various food sources, particularly those rich in Lactobacillus species, are well-recognized for their probiotic properties. Edible mushrooms are rich with their nutrient-dense composition, including carbohydrates, proteins, fibers, minerals, vitamins, and lipids, which stand out as a promising bio-source for several biological uses.

An insight into pyocyanin: production, characterization, and evaluation of its in vitro antibacterial, antifungal, antibiofilm and in vivo anti-schistosomal potency.

Background: Tackling the high demand for alternative therapeutic options, especially for multi-drug-resistant organisms, has awakened interest in naturally originated biomolecules such as pyocyanin (PYO). Herein, PYO-producing bacterium was isolated and PYO was extracted, characterized, and its antagonistic potency was scrutinized against a vast array of prokaryotic and eukaryotic water pathogens, either in free-living or biofilm lifestyles, both in vitro and in vivo.

Results: Initially, sp.

Inhibition of bacterial attachment to polyethersulfone membranes using aminophenol compounds in static and continuous flow systems.

Biofouling is the most challenging problem associated with membrane-based filtration technology. Biofouling deteriorates membranes used in filtration process and decreases the efficiency of membrane productivity used in separation fields, thus increasing the technology cost of membrane-based filtration process. Several approaches exist to control biofouling; membrane surface modification has recently been used to resist bacterial attachment and biofilm formation.

Prediction of single nucleotide polymorphisms of RNA dependent RNA polymerase for the potato leafroll virus using computational and experimental approaches.

Potato leafroll disease, caused by potato leafroll virus (PLRV), is one of the most devastating diseases, resulting in significant losses to the potato crop. Research on comprehensive studies examining the prediction of mutations in PLRV genes for this viral disease is limited. This study aims to quantify and characterize the accumulation of these genetic mutations by predicting SNPs for PLRV RNA-dependent RNA polymerase (RdRP) using computational approaches.

Therapeutic potential of greenly synthesized selenium nanoparticles against experimental cyclosporiasis.

Cyclospora cayetanensis (C. cayetanensis), an opportunistic intracellular coccidian, is responsible for chronic debilitating diarrheal outbreaks possessing life-threatening penalties, especially in immunocompromised patients. The solemn therapeutic agents against cyclosporiasis are limited by their grave effects and high recurrence rate.

Investigating the possible role of toxoplasmosis and Interleukin-1β variants on the immune response in Egyptian diabetic patients.

The study assesses toxoplasmosis seroprevalence in Type 2 Diabetes Mellitus, identifies the potential risk factors, and examines IL-1β expression levels and polymorphisms in those infected with T. gondii. One hundred healthy controls and 200 diabetic patients participated in the study.

Synthesis and characterization of functionalized chitosan coupled with phenolic aldehyde to thwart antibiotics-resistant bacteria with antioxidant and anti-inflammatory properties: In vitro evaluations and computational investigations.

This research aims to synthesize a functionalized chitosan derivative (Cs-Ph) to impede the proliferation of clinical antibiotics-resistant bacteria through conjugating carbonyl group of phloretin (Ph) as a bioactive agent with -NH2 along the chitosan (Cs) chain. The synthesis of Cs-Ph was substantiated using elemental, H NMR, FT-IR, SEM, and UV-vis spectra analyses. Elemental analysis findings demonstrated that the deacetylation and substitution degrees were 75.

Isolation and characterization of phages ΦZC2 and ΦZC3 against carbapenem-resistant Acinetobacter baumannii, and efficacy of ΦZC3 on A549 cells.

Background: Acinetobacter baumannii is an opportunistic pathogen and a major causative agent of hospital-acquired infections. This pathogen can acquire various antibiotic resistance genes, including those conferring resistance to last-resort antibiotics such as carbapenems. MDR A.

Biochemical characterization of a novel purified lectin extracted from Pleurotus ostreatus mushroom for its antiviral activity.

Viruses are responsible for numerous serious outbreaks and pandemics worldwide. In this context, lectins, which are carbohydrate-binding proteins, have garnered attention due to their antiviral properties against RNA and DNA viruses. The antiviral potential of the purified and well-characterized lectin from Pleurotus ostreatus (POL) was assessed against various viruses.

The XEC Variant: Genomic Evolution, Immune Evasion, and Public Health Implications.

Narrative review synthesizes the most current literature on the SARS-CoV-2 XEC variant, focusing on its genomic evolution, immune evasion characteristics, epidemiological dynamics, and public health implications. To achieve this, we conducted a structured search of the literature of peer-reviewed articles, preprints, and official surveillance data from 2023 to early 2025, prioritizing virological, clinical, and immunological reports related to XEC and its parent lineages. Defined by the distinctive spike protein mutations, T22N and Q493E, XEC exhibits modest reductions in neutralization in vitro, although current evidence suggests that mRNA booster vaccines, including those targeting JN.

Bio-Fabricated Aluminum Oxide Nanoparticles Derived from Waste Pharmaceutical Packages: Insight into Characterization and Applications.

This study examines the environmental challenges posed by azo-dye pollutants and aluminum industrial waste. Aluminum oxide nanoparticles (P/AlO-NPs) were produced using a green method that utilized pharmaceutical packaging waste as an aluminum source and marine algae extract () as reducing and stabilizing agents and that was characterized by XRD, EDX, SEM, TEM, and zeta potential. Batch biosorption studies were performed to assess the effectiveness of P/AlO-NPs in removing CR dye from aqueous solutions.

Diagnostic and Prognostic Roles of miR-155 and miR-3173 in Breast and Ovarian Cancer: Implications for Early Detection and Personalized Treatment.

The current study underscores the potential role of miRNAs, specifically miR-3173 and miR-155, as promising biomarkers for breast and ovarian cancers (BC and OC). The primary objective was to evaluate the expression levels of these miRNAs in cancer patients compared to healthy individuals, assess their diagnostic accuracy, and explore their associations with cancer progression and prognosis. This study involved 60 participants, comprising 30 patients diagnosed with primary BC and 30 patients with epithelial ovarian cancer (EOC).

May bacterial meningitis pave the way for a toxoplasmosis flare-up: a cross-sectional study from Egypt.

Background: The probable association of Toxoplasma gondii (T.gondii) flare-up/co-existence with bacterial meningitis is yet to be elucidated. This study aimed to investigate the possible incidence of T.

Anti-inflammatory and anti-diabetic role of Ashwagandha (Withania somnifera) in a type 2 diabetes mellitus mouse model: a study using histological, molecular, and pathological parameters.

Type 2 diabetes mellitus (T2DM) is an extensive metabolic disorder that imposes significant health and economic problems worldwide. It is characterized by chronic hyperglycemia, insulin resistance, and systemic inflammation. T2DM is linked with an increased risk of terrible difficulties, including cardiovascular disease, neuropathy, and nephropathy.