Corrigendum: Fabrication of bioactive nanocomposites from chitosan, cress mucilage, and selenium nanoparticles with powerful antibacterial and anticancerous actions.

[This corrects the article DOI: 10.3389/fmicb.2023.

Foot-and-mouth disease: genomic and proteomic structure, antigenic sites, serotype relationships, immune evasion, recent vaccine development strategies, and future perspectives.

Foot-and-mouth disease (FMD) is a highly contagious and transmissible disease that can have significant economic and trade repercussions during outbreaks. In Egypt, despite efforts to mitigate FMD through mandatory immunization, the disease continues to pose a threat due to the high genetic variability and quasi-species nature of the FMD virus (FMDV). Vaccines have been crucial in preventing and managing FMD, and ongoing research focusses on developing next-generation vaccines that could provide universal protection against all FMDV serotypes.

A tailored 4G -triazine-based dendrimer vehicle for quercetin endowed with MMP-2/9 inhibition and VEGF downregulation for targeting breast cancer progression and liver metastasis.

Motivated by our recent research progress on the exploitation of -triazine dendritic platforms as bioactive carriers for well-known anticancer agents and/or targeting ligands, we set out to synthesize new rationally designed dendrimers endowed with MMP-2/9 inhibition potential for halting both breast and liver cancer progression with reduced off-target side effects. New three and four generation -triazine based dendrimers were developed to incorporate potential ZBGs (Zinc Binding Groups) and carboxyl terminal groups to facilitate direct conjugation of anti-cancer drugs (quercetin) and/or targeting ligands (lactobionic acid) through a biodegradable ester bond. Compared to free quercetin (QUR), MTT assay revealed that all the quercetin-coupled dendrimers displayed better anticancer potential (IC = 12.

Synergistic Effects of Lactobacillus acidophilus and Balanites aegyptiaca in Managing Hyperglycemia, Oxidative Stress, and Inflammation in Diabetic Rats.

Background: Diabetes mellitus is a chronic condition characterized by persistent hyperglycemia, which can lead to serious complications if not managed effectively. Recent interest has grown in exploring the potential of probiotics and prebiotics as complementary therapies. This study investigates the combined effects of the probiotic Lactobacillus acidophilus and the prebiotic Balanites aegyptiaca on blood glucose levels, oxidative stress, and inflammatory markers in an alloxan-induced diabetic rat model.

Exploring Thieno/Furo[2,3-b]pyridines as new scaffolds for potential FAK inhibition: Design, synthesis, biological evaluation and in silico studies.

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that plays a vital role in regulating cancer cell survival, proliferation, migration, and angiogenesis. Aiming to explore new potent inhibitors, a series of thieno/furo[2,3-b]pyridine derivatives was designed and synthesized. The newly synthesized compounds were evaluated for their in vitro anti-proliferative activity against human liver (HUH-7), lung (A549) and breast (MCF-7) cancer cell lines, in addition to their cytotoxic activity against normal lung cell line (WI-38) to predict their safety profile.

Mitigating murine acute and chronic Coxsackievirus B3-induced myocarditis with human right atrial appendage-derived stromal cells.

We previously have shown the potential of human endomyocardial biopsy (EMB)-derived cardiac adherent proliferating cells (CardAPs) as a new cell-therapeutic treatment option for virus-induced myocarditis. To overcome the limited cell yield per EMB, CardAPs have been isolated from the human right atrial appendage (RAA) in view of allogeneic application and off-the-shelf use. We aimed to investigate the cardioprotective and immunomodulatory potential of RAA-CardAPs in experimental acute and chronic Coxsackievirus B3 (CVB3)-induced myocarditis upon injection in the viral and inflammatory phase.

Metal-organic framework MIL-101(Fe) functionalized with folic acid as a multifunctional nanocarrier for targeted chemotherapy-photodynamic therapy.

A novel folic acid-conjugated, iron-based MOF (MIL-101(Fe)) loaded with 1,8-acridinediones (DO8) was developed for targeted photodynamic therapy (PDT) of HepG-2 cells. This composite aims to trigger an anticancer response through sequential PDT and chemotherapy. The nanocomposite exhibited high stability in a physiological environment with a pH of 7.

Sex differences in age-related cardiac and splenic S100A9 and NLRP3 expression.

Age is an important risk factor for cardiovascular diseases and is associated with a systemic, low-grade inflammation, so-called inflammaging. We aimed to investigate the impact of age and sex on the inflammatory markers S100A9 and components of the NLRP3 inflammasome at an early stage in the aging process, using mature adult and middle-aged/perimenopausal mice. Given the importance of the cardiosplenic axis in heart failure, the spleen was analyzed in addition to the left ventricle and cardiac fibroblasts.

Molecular genomic insights into melanoma associated proteins PRAME and BAP1.

Melanoma, a globally prevalent skin cancer with over 325,000 new cases annually, necessitates a comprehensive under- standing of its molecular components. This study looks at the PRAME (cutaneous melanoma-associated antigen) and BAP1 (gene controlling gene-environment interactions) proteins. Both PRAME and BAP1 are associated with critical genomic alterations that significantly influence melanoma progression and patient outcomes.

Bioactive bacterial cellulose/chitosan/sodium alginate composite film functionalized with Moringa oleifera seed extract: Antimicrobial, anticancer, and molecular docking studies.

In this study, composite films (BC/Ch/SA/EEMS) were fabricated using the casting method by incorporating bacterial cellulose (BC), chitosan (Ch), and sodium alginate (SA) with ethanolic Moringa seed extract (EEMS). HPLC analysis detected 16 polyphenolic compounds in EEMS, with Rutin (59.56 μg/mL) the most abundant, while GC-MS analysis identified 11-octadecenoic acid (88.

Synthesis, characterizations and disinfection potency of gelatin based Gum Arabic antagonistic films.

Water-borne infections are considered as one of the major risky concerns regarding the sanitary state of water bodies dedicated to drinking water supply. Therefore, the employment of environmentally benign materials in water/wastewater treatment is an indispensable aspect to solve the water crisis problem in an eco-friendly and economic manner. This study describes the synthesis, characterization, and disinfection potency of different formulas of gelatin-based Gum Arabic composites, for the first time.

L. Methanolic Extract Protects the Brain of Male Rats Against Alzheimer's Disease.

Alzheimer's disease (AD) occurs as a result of a chronic neurodegenerative disorder that is most frequently linked to a decline in cognitive function and memory. Twenty-four male rats were divided into four groups ( = 6); Group I was the negative control, Group II was the AlCl-positive control, and Group III and Group IV were treated with 100 mg and 200 mg/kg of methanolic extract, respectively. Aluminum chloride intoxication in Group II increased lipid peroxidation and decreased antioxidant parameters and affected interleukin-6 (IL-6), the tumor necrosis factor-alpha (TNF-α), acetylcholinesterase (AChE), and amyloid beta (Aβ), which lead to the induction of AD through injuring brain cells of AD rats.

Fabrication of biosynthesized nickel ferrites nanoparticles and evaluation of their insecticidal efficacy on beetles (Blaps polychresta) testicular integrity.

Green synthesis of nanoparticles has emerged as a significant strategy to develop effective and eco-friendly insecticide agents to combat insecticide resistance and preserve environmental integrity and biodiversity. This study was thus designed to fabricate novel green synthesized NiFeO nanoparticles (NiFe NPs) and investigate their potential insecticidal effects for the first time using Blaps polychresta beetle as an agricultural coleopteran pest model. Therefore, we prepared NiFe NPs following the hydrothermal synthesis procedure in the presence of lemon juice.

Toxicological investigations of biosynthesized nickel ferrites nanoparticles on midgut epithelium of Blaps polychresta as nanopesticides: Structural damages and oxidative stress.

The development of eco-friendly insecticides with the ability to overcome insecticide resistance remains a thorny issue. This study therefore intends to evaluate the effectiveness of green synthesized nickel ferrite nanoparticles (NiFeO NPs) as nanopesticides in this first report using darkling beetles, Blaps polychresta, as a model. The biosynthesized NiFeO NPs were characterized employing various approaches, including FTIR, UV-Vis spectroscopy, XRD, XPS, and VSM.

Exploring Anticitrullinated Antibodies (ACPAs) and Serum-Derived Exosomes Cargoes.

Background: Autoantibodies such as rheumatoid factor (RF) and anticitrullinated protein autoantibodies (ACPAs) are useful tools for rheumatoid arthritis (RA). The presence of ACPAs against citrullinated proteins (CPs), especially citrullinated fibrinogen (cFBG), seems to be a useful serological marker for diagnosing RA. RA patients' sera were found to be enriched in exosomes that can transmit many proteins.

Analysis of gut microbiota variations in patients with Henoch-Schönlein purpura: a comprehensive systematic review.

Objective: The primary purpose of our study was to perform a comprehensive systematic review, aiming to bring out the association between gut microbiota, Henoch-Schönlein Purpura (HSP) and Henoch-Schönlein nephritis (HSPN) patients.

Methods: A systematic review was performed using five electronic databases, including Medline (through PubMed), Scopus, Embase, Cochrane, and Web of Science, from inspection up to March 21, 2024, to detect the studies that assessed the gut microbiota variation in Henoch-Schönlein Purpura (HSP) and Henoch-Schönlein nephritis (HSPN) patients.

Results: Microbial diversity, richness, and composition in HSP patients are decreased compared to the healthy control group.

Effectiveness of fullerene/magnesium oxide nanocomposite in removing ciprofloxacin and tetracycline from aqueous solutions.

The excessive use of antibiotics, including ciprofloxacin (CIP) and tetracycline (TC), poses negative impacts on both human health and ecosystems. In this work, fullerene/magnesium oxide (F/MgO) nanocomposite was prepared and studied as adsorbent for CIP and TC removal. Adding metal oxide to F led to a change in its characteristics which was confirmed by XRD, FTIR, SEM, and TEM.

Computational development of mushroom-6-glucan/paclitaxel as a synergistic complementary medicine for breast cancer therapy.

Background: Breast cancer is chemo-resistant and highly metastatic, often resulting in patient mortality. One of the primary factors contributing to the metastasis and chemotherapy resistance is the presence of cancer stem-like cells. We posited that the natural polysaccharide known as 6-glucans, derived from Pleurotus ostreatus, could effectively counteract the chemotherapy resistance associated with cancer stem-like cells in breast cancer.

GWAS identifies a polyembryony locus in mango: development of KASP and PACE markers for marker-assisted breeding.

Apomixis is a horticultural trait that enables clonal propagation of hybrids by producing asexual embryos from maternal cells in the ovule without meiosis. Many mango cultivars exhibit apomictic polyembryony, where one embryo develops from zygotic tissues and the rest from nucellar tissues, resulting in seedlings that are genetically identical to the mother tree. In L.

A genome-wide association study identified SNP markers and candidate genes associated with morphometric fruit quality traits in mangoes.

Background: Mangoes (Mangifera indica L.) are a widely grown fruit tree crop across the world, but breeding new varieties can take 15-20 years due to its long juvenile period and high heterozygosity. Marker-assisted selection can accelerate breeding new mango cultivars with desirable traits for fruit quality, storage, horticulture, pest and disease resistance, and nutrition.

The optimization of calcareous soil cation exchange capacity via the feather hydrolysate and N-P fertilizers integration.

Adding organic amendments to agricultural systems as sustainable practices is one of the most important stages toward creating a more sustainable and environmentally friendly food system. By increasing soil fertility and nutritional content, organic fertilizers increase plant productivity. Cation Exchange Capacity (CEC) is a vital indicator of soil fertility and plant nutrient availability, which is considered one of the most significant chemical parameters that affect agricultural soil quality.

Diosgenin-Loaded Silver Nanoparticles Mitigate B[a]P-Induced Lung Fibrosis Through Modulation of Oxidative Stress and Inflammatory Pathways.

Background: Lung fibrosis, characterized by the thickening and scarring of lung tissue, is a serious condition often triggered by environmental toxins like Benzo[a]pyrene (B[a]P). Diosgenin, a natural steroidal sapogenin found in plants such as fenugreek and wild yam, has shown potential to protect against lung damage due to its anti-inflammatory and antioxidant properties. However, its clinical application is limited by poor solubility and bioavailability.