Early Diastolic Dysfunction Detection in Hypertension: CMR-Derived Left Atrial Strain.

Rationale And Objectives: This study aimed to investigate the role of cardiac magnetic resonance (CMR)-derived left atrial (LA) strain parameters in evaluating early cardiac dysfunction in hypertensive patients and to assess their diagnostic utility for left ventricular diastolic dysfunction (LVDD).

Methods: A total of 150 hypertensive patients and 60 healthy controls were retrospectively enrolled, with all participants undergoing both echocardiographic and CMR examinations. Hypertensive patients were stratified by LVDD severity based on current guidelines.

Effect of a glycosaminoglycan-rich eggshell membrane dressing with in situ grown cu-mof on diabetic wound healing.

Chronic diabetic wounds pose significant clinical challenges due to persistent inflammation, impaired neovascularization, and recurrent infections. This study is based on the natural three-dimensional porous structure and bioactive components of eggshell membranes (ESM), on which we assembled an in situ Cu@MOF, richly loaded with Cu and Zn, to create a multifunctional wound dressing (ESM@Cu-MOF). The characterization results demonstrated that the ESM@Cu-MOF exhibited excellent antibacterial performance and cell compatibility, with pH-responsive ion release characteristics.

Investigating the Causal Role of Neurotrophic Factors in Low Back Pain and Sciatica: A Mendelian Randomization Study.

Background: Low back pain (LBP) and sciatica are among the most prevalent musculoskeletal disorders, leading to significant disability and an economic burden. Neurotrophic factors, including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and glial cell-derived neurotrophic factor (GDNF), play critical roles in pain modulation and neuronal function. While NGF-targeting monoclonal antibodies have shown potential in treating chronic pain, their efficacy and safety remain under debate.

Preoperative ternary classification using DCE-MRI radiomics and machine learning for HCC, ICC, and HIPT.

Objectives: This study develops a machine learning model using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) radiomics and clinical data to preoperatively differentiate hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), and hepatic inflammatory pseudotumor (HIPT), addressing limitations of conventional diagnostics.

Materials And Methods: This retrospective study included 280 patients (HCC = 160, ICC = 80, HIPT = 40) who underwent DCE-MRI from 2008 to 2024 at three hospitals. Radiomics features and clinical data were extracted and analyzed using LASSO regression and machine learning algorithms (Logistic Regression, Random Forest, and Extreme Gradient Boosting), with class weighting (HCC:ICC:HIPT = 1:2:4) to address class imbalance.

Comparative Outcomes of Nurse-Led Early Mobilization Versus Standard Care in Acute Pancreatitis: A Randomized Controlled Trial.

Purpose: Acute pancreatitis (AP) is a serious and sometimes life-threatening condition that can lead to complications like organ failure and infection. While early mobility has shown benefits in other hospital settings, its role in AP care remains underexplored. This study assessed the impact of a nurse-led early mobilization program on recovery in AP patients.

Regulated programmed cell death in acute lung injury: from pathogenesis to therapy.

Acute lung injury (ALI) is a common, life-threatening lung disease with a high mortality rate, primarily associated with acute and severe inflammation of the lungs. There are many factors that lead to ALI, and abnormally advanced regulated programmed cell death (RCD) is considered to be an important process in the pathological process of ALI. Various forms of RCD have been discovered in recent years, including apoptosis, necroptosis, autophagy, ferroptosis and pyroptosis.

Revealing the core immunotoxicity of di-n-pentyl phthalate exposure in murine models using single-cell RNA sequencing.

The phthalate derivative di-n-pentyl phthalate (DNPP) is an extensively distributed environmental contaminant that has been implicated in various pathological conditions. The immune system critically regulates disease pathogenesis through complex interactions. However, current toxicological research has failed to comprehensively characterize DNPP-induced immunotoxicity.

Muscone inhibits ferroptosis for neuroprotection in a Parkinson's disease model.

Parkinson's disease (PD) is a common neurodegenerative disorder with no currently available effective treatments. Muscone is a bioactive compound extracted from musk, a widely used traditional Chinese medicine, that has demonstrated notable pharmacological properties and is considered beneficial for various models of neurological disorders. However, no studies have in vestigated the potential link between muscone and PD.

Serum Metabolome Profiling Reveals Biomarkers to Predict Malignant Brain Edema Following Endovascular Stroke Therapy.

Metabolomics reflects the body's metabolic state and holds substantial promise for identifying associated biomarkers and exploring pathological processes. This study used serum metabolomics to predict malignant brain edema (MBE) following endovascular therapy (EVT) for acute ischemic stroke (AIS) and investigate the underlying mechanisms. In this prospective observational study, we enrolled patients with anterior circulation large vessel occlusion who underwent successful recanalization post-EVT for AIS, including those with or without concomitant hemorrhagic transformation.

Clinical diagnostic and prognostic value of homocysteine combined with hemoglobin [f (Hcy-Hb)] in cardio-renal syndrome caused by primary acute myocardial infarction.

Background: Cardio-renal syndrome (CRS), characterized by multi-organ interaction, is frequently overlooked in clinical practice. It poses significant challenges in treatment, leading to poor long-term prognosis and substantial economic burden on patients' families. This study, based on a 10-year multi-center real-world investigation, identified that hyperhomocysteinemia and hypohemoglobinemia in myocardial infarction (MI) patients are associated with an increased risk of developing CRS.

Effects of Dan Shen () on blood pressure management in hypertensive patients: a randomized controlled trial.

Objective: This randomised, double-blind, placebo-controlled trial aimed to evaluate the efficacy and safety of (Dan Shen) in the management of primary hypertension.

Methods: From April 2023 to September 2024, 320 patients aged 30-75 years with diagnosed primary hypertension were enrolled at Ganzhou Hospital of Southern Medical University (Ganzhou People's Hospital). Patients were randomised to receive either intravenous (20 mL diluted in 200 mL of 5% glucose daily for 12 weeks) or a placebo with identical appearance and administration.

A Serum DLL1 and CRP dual-marker model for bacterial infection detection in patients with decompensated cirrhosis: A dual-cohort diagnostic study.

ObjectiveBacterial infections (BIs) in decompensated cirrhosis are associated with high morbidity and mortality but remain diagnostically challenging due to limited conventional biomarker accuracy. We aim to evaluate the utility of serum Delta-like ligand 1 (DLL1) for BI detection in patients with decompensated cirrhosis.MethodsIn this dual-cohort prospective study, 320 hospitalized patients with decompensated cirrhosis were consecutively enrolled and stratified into derivation (n = 224) and independent validation (n = 96) cohorts.

A machine learning model based on CT radiomics for preoperatively differentiating intrahepatic mass-type cholangiocarcinoma and inflammatory pseudotumours.

Objective: Intrahepatic cholangiocarcinoma (ICC) and hepatic inflammatory pseudotumours (IPTs) share similar imaging features, leading to unnecessary biopsies and surgeries. Accurate preoperative differentiation is essential. Current studies using traditional imaging analysis have limited accuracy.

FAM64A silencing inhibits the proliferation, migration, invasion, and epithelial-mesenchymal transition in ovarian cancer cells via activating Hippo pathway.

Objective: Ovarian cancer (OC) is a highly aggressive malignancy in females. We aim to investigate the potential gene target and examine its impact on OC.

Methods: Hub genes were determined using protein-protein interaction networks based on differently expressed genes in GSE12470 and GSE14407 datasets.