Global Leadership Initiative on Malnutrition as a predictor of mortality and prolonged hospitalization in emergency department patients: A prospective cohort study.

Background: Early diagnosis of malnutrition is essential for rapid decision-making regarding nutrition care to improve patient outcomes. We aimed to evaluate the prevalence of malnutrition using the Global Leadership Initiative on Malnutrition (GLIM) criteria and to assess the association of GLIM with 1-year mortality and length of hospital stay (LOS) in patients admitted to an emergency department (ED).

Methods: Prospective cohort study conducted in the ED of a university hospital.

The Use of Unmanned Aerial Vehicles (UAV) on Delivering Biological Samples for COVID-19 and Tuberculosis Diagnosis: A Scoping Review.

Purpose: To identify and review scientific evidence from experimental studies utilizing unmanned aerial vehicles (UAVs) to transport samples for the diagnosis of COVID-19 and tuberculosis (TB). This exploratory study aims to support the future development of UAVs for transporting biological samples within the Brazilian Unified Health System (SUS).

Methods: This scoping review defined its eligibility criteria using the PECO acronym, focusing on: Population: biological samples for diagnosing COVID-19 or TB; Exposure: UAV transportation; Comparator: land transportation; Outcomes: Cost, effectiveness, methods for sample preservation, flight parameters (time, altitude, speed, distance), and quality of transported samples.

Multifunctional polyamidoxime-co-polyethyleneimine tailored cellulose derived from sustainable biomass for effective removal of acidic dye pollutants from wastewater.

Multifunctional polymers derived from waste biomass are under intense global investigation for wastewater remediation owing to their environmental advantages. Therefore, this study reports the synthesis of a novel polyamidoxime-co-polyethyleneimine multifunctional cellulose, which was used as an adsorbent for the removal of acidic dye pollutants. Morphological, structural, and surface studies were performed using several techniques.

Shared biological pathways linking ADHD and cortisol variability are related to externalizing behaviors.

Altered cortisol regulation is implicated in Attention-Deficit/Hyperactivity Disorder (ADHD), but causality remains debated. While meta-analyses suggest that lower basal cortisol levels, especially in the morning, correlate with ADHD, study heterogeneity prompts further inquiry. Leveraging post-genome-wide association approaches, we examined morning cortisol levels (n = 25,314) and ADHD (n = 225,543).

Laparoscopic Intraperitoneal Onlay Mesh Versus Robotic Retromuscular for Small- and Medium-Sized Ventral Hernia Repair: A Systematic Review and Meta-Analysis.

This study aims to perform a systematic review and meta-analysis to compare the laparoscopic intraperitoneal onlay mesh (IPOM) versus the robotic retromuscular (RM) techniques and their respective outcomes for small and medium-sized ventral hernia repair. A comprehensive online search was conducted using PubMed, Cochrane, and Embase. Studies comparing laparoscopic IPOM to robotic RM techniques were included.

Antioxidant potential of alpha-lipoic acid in mitigating progression of experimental periodontitis.

This study aimed to evaluate the effects of alpha-lipoic acid supplementation, a well-known antioxidant with therapeutic potential, on the progression of experimental periodontitis in rats. Eighteen male Wistar rats were randomly assigned to three groups (n = 6 per group): control, periodontitis, and periodontitis treated with alpha-lipoic acid. Periodontitis was induced by placing bandages around the lower first molars for 14 days.

Comparative study of autonomic dysfunction between Parkinson's disease with LRRK2, PRKN, and GBA mutations.

Background: Autonomic symptoms are among the most important factors determining the quality of life in patients with Parkinson's disease (PD). This study aimed to assess the profile of autonomic dysfunction symptoms in three groups of patients with genetic PD, carrying mutations in , , and genes, compared with subjects with sporadic PD.

Methods: This case-control observational secondary analysis of prospectively collected data was performed on 742 patients (485 in the sporadic group, 165 in the LRRK2 group, 85 in the GBA group, and nine in the PRKN group).

Preparation and characterization of different immobilized and chemically modified preparations of lipase B from Candida antarctica: is it the activation energy a good indicator of the biocatalyst expressed activity?

Lipase B from Candida antarctica immobilized on octyl (via interfacial activation) and octyl-vinyl sulfone (covalently attached) agarose beads via different immobilization protocols was submitted to amination and/or glutaraldehyde modifications. The catalytic performance of the resulting biocatalysts significantly varied across different substrates: using octyl-CALB with the double modification, activity increased 3.5 fold versus triacetin and decreased by 5 % using R-methyl mandelate, while using the covalent biocatalyst, activity increase by 2.

Progress and challenges in the use of Cofilin-1 as a prognostic and predictive biomarker for cancer management.

Cofilin-1 (CFL1) is an actin-regulating protein encoded by the CFL1 gene and plays a central role in cytoskeletal dynamics, cell motility, and invasion-processes critical for tumor progression and metastasis. Aberrant CFL1 expression has been linked to poor prognosis, therapeutic resistance, and increased metastatic potential across several human cancers. This review consolidates clinical evidence from studies involving human samples over the past 15 years, highlighting CFL1 as a candidate prognostic and predictive biomarker.

Efficacy and Safety of Bariatric Surgery in Well-Compensated Liver Cirrhosis: A Systematic Review and a Single-Arm Meta-analysis.

Introduction: The global rise in obesity and liver disease underscores the significance of bariatric and metabolic surgery (BMS) in treating severe obesity and improving liver function. Although liver failure is often considered a contraindication for elective surgeries, the role of bariatric surgery in patients with compensated cirrhosis has been increasingly explored.

Methods: We systematically searched PubMed, Embase, and Cochrane without temporal restrictions, in January 2025 for randomized controlled trials and observational studies.

Beyond the Value: The Clinical Story of Pain after Inguinal Hernia Repair.

Clinical studies often define their findings as statistically significant based solely on a value of less than .05. In hernia surgery, pain intensity is a key patient-reported outcome, commonly measured using the visual analogue scale (VAS).

Imidazopyridine DSH65 induces intrinsic apoptosis and cell cycle arrest in burkitt lymphoma cells.

Burkitt lymphoma (BL) is a germinal center-derived B-cell neoplasm. Due to the aggressiveness of this neoplasm, treatment must be started quickly. Despite innovation in the pharmaceutical industry, BL has high recurrence and mortality rates.

Prevalence of malnutrition and its association with outcomes in heart failure: A systematic review and meta-analysis.

Background & Aims: Impairment in nutritional status (i.e. malnutrition) can significantly affect the progression and prognosis of patients with heart failure (HF).

High-Power Short-Duration Ablation Versus Conventional Power Ablation in Pulmonary Vein Isolation in Patients With Atrial Fibrillation: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Background: High-power short-duration (HPSD) ablation has emerged as a promising alternative to conventional power delivery (CPD) for pulmonary vein isolation (PVI) among patients with atrial fibrillation (AF), though its efficacy, procedural efficiency, and safety profile remain uncertain.

Aims: To evaluate and compare the efficacy, procedural efficiency, and safety of HPSD versus CPD ablation strategies for PVI in patients with AF through a systematic review and meta-analysis of randomized controlled trials (RCTs).

Materials And Methods: PubMed, Embase, Cochrane Library, and ClinicalTrials.

Selenite protects human peripheral blood mononuclear cells (PBMCs) from CdCl cytotoxicity.

The potential role of selenium (Se) in modulating cadmium (Cd) cytotoxicity in human peripheral blood mononuclear cells (PBMCs) was investigated by assessing pro- and anti-inflammatory as well as redox biomarkers. We also examined the potential synergistic effects of SARS-CoV-2 N-protein with Cd in PBMCs. PBMCs were isolated from adults and treated for 48 h with sodium selenite (Na₂SeO₃; 0.

Contextual factors in value-based decision support to enhance health technologies adoption: the case of biosimilars.

Introduction: Biosimilar medicines play a critical role in enhancing global health outcomes by improving access to effective biologic treatments. However, their acceptance and implementation, particularly in emerging markets, depend not only on clinical evidence but also on the integration of societal, individual, and cultural values. This paper explores how value-based decision-making can support the adoption of biosimilars across diverse contexts.

Evaluation of the use of the myocardial performance index as a parameter of cardiac function in two experimental models of heart disease: myocardial infarction and pulmonary hypertension.

Myocardial performance index (MPI) has been used in the estimation of ventricular function in a non-invasive way through echocardiography. This index has presented relevant results in clinical and experimental studies. However, there are no studies evaluating whether this index correlates with other cardiac parameters in experimental models of heart disease, such as monocrotaline-induced pulmonary artery hypertension (PAH) and acute myocardial infarction (AMI).

Effects of Incorporation of Essential Oils in the Jersey Cow Diet on the Quality of Produced Dairy Products (Milk, Cream, and Colonial Cheese).

Essential oil blends (EOBs) have been increasingly studied for their multifunctional benefits in animal nutrition and food science. This study evaluates the impact of an EOB composed of eucalyptus and peppermint oil on the physicochemical, microbiological, and sensory characteristics of dairy products-milk, cream, and colonial cheese. Forty lactating cows were assigned to two groups: control and EOB addition (3.

In Silico and In Vivo Pharmacological Evaluation of Iridoid Compounds: Geniposide and Asperuloside Profile Study Through Molecular Docking Assay and in the Model.

Iridoids are compounds recognized for their neuroprotective properties and their potential application in the treatment of neurodegenerative diseases. Geniposide (GP) and asperuloside (ASP) are iridoids that have demonstrated some biological activities. In this study, the potential neuroprotective effects of these iridoids were evaluated through in silico and in vivo assays, using () strains CF1553 (sod-3::GFP), GA800 (cat::GFP), and CL2166 (gst-4::GFP).

Dietary Intake, Body Composition, and Muscle Function in Resistance-Untrained Strict Vegetarian and Non-Vegetarian Women: An Exploratory Cross-Sectional Study.

Strict vegetarian and non-vegetarian diets may differ in quantity and quality of nutrient intake. This study aimed to compare dietary intake, lean mass, bone mineral content (BMC), bone mineral density (BMD), and muscle function between resistance-untrained strict vegetarians (SV) and non-vegetarians (NV) women. Seventy-one untrained women participated in this study, including 35 SV (28.

Science diplomacy: A global research field? Findings from a bibliometric analysis of the science diplomacy scholarship of the past twenty years.

Science diplomacy is a unique research field that is driven and shaped by scholars and practitioners alike. This study examines whether and how recent trends in the broader science diplomacy discourse have impacted scholarship on the topic. First, it examines whether the pertinent scholarship is as international in outlook as practitioners have made science diplomacy out to be.

Drain versus no drain in elective open incisional hernia repair: a propensity score matching analysis using the ACHQC database.

Introduction: The benefits of prophylactic drain placement are controversial during elective open incisional hernia repair. The aim of this study was to evaluate drain impact on surgical site occurrences (SSO) and infection (SSI) after open elective incisional hernia repair with mesh.

Methods: A retrospective review of prospectively collected data from the Abdominal Core Health Quality Collaborative (ACHQC) was performed to include all adult patients who underwent elective open incisional hernia repair with permanent synthetic or resorbable synthetic mesh.