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http://dx.doi.org/10.1186/s40246-025-00790-1 | DOI Listing |
Hum Genomics
August 2025
Laboratory of Genomic Medicine, Center of Experimental Research, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil.
Dis Model Mech
July 2025
Center for Precision Disease Modeling, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
People carrying two APOL1 risk alleles (RA) - G1 or G2 - are at greater risk of developing human immunodeficiency virus (HIV)-associated nephropathy (HIVAN). However, it remains unclear whether the encoded protein(s) (APOL1-RA) and HIV-1 Nef interact to induce podocyte cell death. Here, we generated transgenic flies that express APOL1-G1 (derived from a child with HIVAN) and HIV-1 nef specifically in the nephrocytes, the fly equivalent of mammalian podocytes, and assessed their individual and combined effects on the nephrocyte filtration structure and function.
View Article and Find Full Text PDFRev Bras Ginecol Obstet
July 2025
Universidade Estadual Paulista Instituto de Biociências de Botucatu Departamento de Biofísica e Farmacologia BotucatuSP Brasil Departamento de Biofísica e Farmacologia, Instituto de Biociências de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brasil.
Objective: This study aims to compare the plasma protein profiles between 7 preeclampsia patients with severe features (PE+) and 7 preeclampsia patients without severe features (PE-) and 10 healthy pregnancies (HP); identify differentially expressed proteins among these groups and explore the altered signaling pathways and their association with the severity of this cardiovascular condition.
Methods: Plasma proteins were quantified using mass spectrometry, followed by comprehensive bioinformatics and statistical analyses. Protein identification and annotation were performed using UniProt and PatternLab for Proteomics.
BMC Nephrol
July 2025
H3-Africa Kidney Disease Research Network, University of Ghana, Korle- bu, Accra, Ghana.
Background: There is evidence that variants of the Apolipoprotein L1 gene in Africans and people of African descent increase the risk of developing chronic kidney disease (CKD). A study conducted by the H3Africa Kidney Disease Research Network showed that 28.2% of the Ghanaian study population carried 2 APOL1 high-risk variants.
View Article and Find Full Text PDFClin Sci (Lond)
May 2025
National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, U.S.A.
In USA, six million individuals with Sub-Saharan ancestry carry two APOL1 high-risk variants, which increase the risk for kidney diseases. Whether APOL1 high-risk variants increase other diseases under dyslipidemia remains unclear and requires further investigation.We characterized a mouse model to investigate the role of APOL1 in dyslipidemia and cardiovascular diseases.
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