Preliminary study on cervical vestibular-evoked myogenic potentials tuning changes in acute low-tone sensorineural hearing loss.

Background: Acute low-tone sensorineural hearing loss (ALHL) is frequently associated with endolymphatic hydrops. Cervical vestibular-evoked myogenic potentials (cVEMP) have been used to detect saccular hydrops, especially in Meniere's disease, but their role in ALHL is unclear.

Objective: To preliminarily investigate whether cVEMP tuning frequency shifts are associated with hearing outcomes in patients with ALHL.

Antimicrobial resistance of in Korea for two decades.

Purpose: Antimicrobial-resistant (AMR) has become a global concern. To assess AMR patterns in Korea, we analyzed the genetic diversity of the AMR-determining sites (ARDS) in across in 285 samples collected over two decades.

Materials And Methods: -positive samples were collected from various groups: males at one referral center (ORC) from 2014 to 2019 (G1; 43) and from 2020 to 2023 (G2; 54), males at primary care clinics (PCCs) in 2018-2019 (G3; 84), female sex workers at a regional healthcare center in 2004 (G4; 51), and females at PCCs in 2018-2019 (G5; 53).

Establishing consensus recommendations for metastatic hormone-sensitive prostate cancer in South Korea: A modified Delphi study.

Purpose: Consensus is lacking among South Korean urologists on the appropriate treatment of metastatic hormone-sensitive prostate cancer (mHSPC). A modified, Delphi-based consensus on managing mHSPC patients was developed to support clinical decision-making.

Materials And Methods: Thirty-six questions on mHSPC treatment were developed by an expert committee (five urologists).

Non-eosinophilic esophagitis eosinophilic gastrointestinal diseases are more prevalent than eosinophilic esophagitis in Korean children: from a multicenter study based on new diagnostic criteria and nomenclature.

Background: Eosinophilic gastrointestinal diseases (EGIDs) are chronic inflammatory disorders characterized by eosinophilic infiltration of the gastrointestinal (GI) tract. This study aimed to investigate the epidemiological and clinical characteristics of pediatric EGIDs in Korea based on the newly established nomenclature and diagnostic guidelines.

Methods: A retrospective analysis was conducted on pediatric patients (0-18 years) with GI symptoms who underwent upper and lower GI endoscopy at five tertiary hospitals in Korea (2010∼2023).

Long-Term Anticoagulation Discontinuation After Catheter Ablation for Atrial Fibrillation: The ALONE-AF Randomized Clinical Trial.

Importance: Data from randomized clinical trials on a long-term anticoagulation strategy for patients after catheter-based ablation for atrial fibrillation (AF) are lacking.

Objective: To evaluate whether discontinuing oral anticoagulant therapy provides superior clinical outcomes compared with continuing oral anticoagulant therapy in patients without documented atrial arrhythmia recurrence after catheter ablation for AF.

Design, Setting, And Participants: A randomized clinical trial including 840 adult patients (aged 19-80 years) who were enrolled and randomized from July 28, 2020, to March 9, 2023, at 18 hospitals in South Korea.

Development and application of an LC-MS/MS method for urinary DNA adduct profiling in residents of environmentally vulnerable areas.

DNA adducts, formed by the covalent binding of reactive electrophiles to DNA, serve as biomarkers of genotoxic exposure and early biological effects. However, non-invasive, high-throughput biomonitoring methods remain underdeveloped. This study developed and validated a robust LC-MS/MS method for simultaneous quantification of six urinary DNA adducts and applied it to assess environmental exposure among residents of polluted and control areas.

Negative pressure wound therapy with a fenestrated penrose drain for refractory seroma following ischial flap: A case report.

Background: Patients with paraplegia are vulnerable to ischial pressure ulcers. Surgical treatments often lead to complications such as seroma and infection, necessitating repeated interventions that increase surgical difficulty. This case report aimed to introduce a novel treatment strategy combining negative pressure wound therapy (NPWT) with a fenestrated Penrose drain to manage refractory seroma in patients with a history of ischial pressure ulcers.

Defining safe operational conditions for two-photon imaging with rhodamine B and SYTO 9 dual-staining.

Two-photon microscopy (TPM) frequently employs dual-staining techniques for simultaneous visualization of cellular structure and viability. Despite widespread use, the safety of combining Rhodamine B (RB) and SYTO 9 dyes under 920 nm excitation has not been thoroughly assessed. This study systematically evaluated cytotoxicity, sensitization, and dermal irritation of RB (20 μg/mL) and SYTO 9 (2.

Strategy for ipsilateral multiple concomitant upper extremity fractures in an elderly polytraumatized patient with severe osteoporosis: A case report.

Rationale: Elderly patients with severe osteoporosis present significant challenges in managing multiple concomitant upper extremity fractures, especially when high-energy trauma is involved. The rarity of such cases necessitates a structured approach to achieve optimal outcomes, balancing surgical intervention and early rehabilitation.

Patient Concerns: A 79-year-old woman presented to the emergency department following a severe car accident.

Advanced therapeutic scaffolds of biomimetic periosteum for functional bone regeneration.

Treating chronic bone injuries and defects remains a significant challenge in orthopedic medicine, impacting patient mobility, recovery time, and healthcare costs. The periosteum, a specialized, vascularized connective tissue covering the outer bone surface, plays a crucial role in osteogenesis and skeletal repair. While regenerating the periosteum is critical to restoring bone structure and function, current treatments face substantial limitations, including limited donor tissue availability, donor site complications, and the risk of immunological rejection.

Comparative Efficacy and Safety of 0.8-L Versus 2-L Polyethylene Glycol-Ascorbic Acid Solutions in Colonoscopy Preparation: A Prospective, Multicenter, Randomized, Controlled Trial.

Background And Aim: High-volume polyethylene glycol (PEG) solutions are associated with low patient compliance, whereas low-volume alternatives pose higher risks of adverse events. We compared a new 0.8-L PEG-ascorbic acid solution containing simethicone to a 2-L PEG-ascorbic acid solution.

Asian consensus on normothermic intraperitoneal and systemic treatment for gastric cancer with peritoneal metastasis.

Peritoneal metastasis (PM) is a major challenge in advanced gastric cancer (GC) with poor prognosis. Normothermic intraperitoneal and systemic treatment (NIPS) has become a promising therapeutic approach. This consensus aims to provide practical recommendations for NIPS treatment for gastric cancer with peritoneal metastasis (GCPM).

International Association of Pancreatology Revised Guidelines on Acute Pancreatitis 2025: Supported and Endorsed by the American Pancreatic Association, European Pancreatic Club, Indian Pancreas Club, and Japan Pancreas Society.

Introduction: The International Association of Pancreatology, alongside the American Pancreatic Association, the European Pancreatic Club, the Indian Pancreas Club, and the Japan Pancreas Society, decided to update its earlier guidelines for the management of acute pancreatitis (AP) given the remarkable advances in our understanding of AP and its management over the last decade.

Methods: These organizations put together a group of international experts to address important issues related to the management of AP. Guideline Development Groups comprising international domain experts framed clinically relevant questions and conducted thorough literature searches and systematic reviews to address the questions.

Erratum: Intraperitoneal Paclitaxel Combined with S-1 Plus Oxaliplatin for Advanced Gastric Cancer with Peritoneal Metastasis: A Phase I Study.

This corrects the article on p. 418 in vol. 21, PMID: 35079443.

Safety and Efficacy of Reduced-Port Versus Conventional Laparoscopic Distal Gastrectomy for Early Gastric Cancer: A Multicenter, Randomized, Non-inferiority Trial (KLASS-12).

Purpose: This trial (KLASS-12) compares the efficacy and safety of reduced-port laparoscopic gastrectomy (RPLG) versus conventional 5-port laparoscopic gastrectomy (CPLG) for early gastric cancer (EGC).

Materials And Methods: This multicenter, open-label, randomized controlled trial enrolled patients diagnosed with gastric adenocarcinoma (T1N0M0) at 15 university hospitals in Korea. Participants underwent RPLG or CPLG with at least D1+ lymph node dissection.

Osteoporotic fracture risk in hypoparathyroidism following total thyroidectomy: a retrospective nationwide cohort study.

Objective: Hypoparathyroidism is an uncommon but significant complication of total thyroidectomy. As the incidence of thyroid cancer increases, the prevalence of hypoparathyroidism also increases. However, its effect on the risk of osteoporotic fractures remains poorly understood.

The Interplay of Angiogenesis and Osteogenesis in Non-Stabilized Incomplete Tibial Fractures: A Temporal Study in Rats.

Prior research on angiogenesis and osteogenesis during bone fracture healing has primarily focused on stabilized models, often within controlled environments. However, the dynamic interplay of these processes in the context of long bone fractures without scaffolds or external factors remains poorly understood. This study investigated the temporal dynamics of angiogenesis and osteogenesis in a non-stabilized incomplete transverse tibia bone fracture model.

Voluntary Swimming Reduces Amyloid Pathology in an Alzheimer's Mouse Brain: An Integrated Amyloid PET/CT and Light-Sheet Microscopy Evaluation.

Purpose: Despite numerous observational studies linking exercise to reduced dementia risk, RCT level evidences remain limited to validate physical activity as an effective resistance-augmenting lifestyle intervention. However, transgenic Alzheimer's disease (AD) mouse models circumvent the confounding factors and adherence challenges of human studies by offering rigorous control of exercise regimens, and the capability for advanced three-dimensional imaging to precisely quantify amyloid burden. Using an integrated platform combining [18F]florapronol PET/CT with light-sheet fluorescence microscopy (LSFM) and tissue clearing techniques, we investigated the effect of a 7-wk voluntary swimming on decreasing beta-amyloid (Aβ) pathology in hAPPsw AD mouse.

Deep Learning-Based Aortic Diameter Measurement in Traumatic Hemorrhage Using Shallow Attention Network: A Path Forward.

The accurate assessment of aortic diameter (AoD) is essential in managing patients with traumatic hemorrhage, particularly during interventions such as resuscitative endovascular balloon occlusion of the aorta (REBOA). Manual AoD measurements are time-consuming and subject to inter-observer variability. This study aimed to develop and validate a deep learning (DL) model for automated AoD measurement in trauma patients requiring massive transfusion.

Functional and Morphological Changes in the Olfactory Epithelium of Mouse Models with Upper Respiratory Inflammation and Olfactory Dysfunction.

Objectives: This study evaluated behavioral tests and histological findings of allergic rhinitis (AR), chronic rhinosinusitis (CRS), and drug-induced anosmia murine models, comparing the results among groups.

Methods: This study established total six animal model groups: control, ovalbumin (OVA) induced AR, OVA/poly(I:C) induced neutrophilic dominant rhinitis, OVA/staphylococcus enterotoxin B induced CRS, two anosmia models induced by 3-methylindole (3-MI) intraperitoneal injection and chronic ZnSO4 intranasal administration (n=5 in each group). Olfactory function was evaluated using an open-field food-finding test and a T-maze test one week after establishing the models.

Comparison of Therapeutic Outcomes Between Concomitant Therapy and Tailored Therapy for Helicobacter pylori: A Multicenter, Prospective, and Randomized Study.

Background: The increasing trend of clarithromycin resistance in Helicobacter pylori (H. pylori) is the primary cause of failure of standard triple therapy. Concomitant therapy is recommended as an alternative in regions with high rates of clarithromycin resistance.

Portable Ultrasound Bladder Volume Measurement Over Entire Volume Range Using a Deep Learning Artificial Intelligence Model in a Selected Cohort: A Proof of Principle Study.

Objective: We aimed to prospectively investigate whether bladder volume measured using deep learning artificial intelligence (AI) algorithms (AI-BV) is more accurate than that measured using conventional methods (C-BV) if using a portable ultrasound bladder scanner (PUBS).

Patients And Methods: Patients who underwent filling cystometry because of lower urinary tract symptoms between January 2021 and July 2022 were enrolled. Every time the bladder was filled serially with normal saline from 0 mL to maximum cystometric capacity in 50 mL increments, C-BV was measured using PUBS.