Targeting the gut-liver axis with dietary polyphenols to ameliorate metabolic dysfunction-associated steatotic liver disease: advances in molecular mechanisms.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a condition that results from metabolic disorders. In addition to genetic factors, irregular and high-energy diets may also significantly contribute to its pathogenesis. Dietary habits can profoundly alter the composition of gut microbiota and metabolites.

Presbyopia-correcting intraocular lenses in eyes with corneal conditions: an update.

Purpose Of Review: Modern presbyopia-correcting intraocular lenses (IOLs) offer a potential solution to address the rising postoperative demand and expectations for spectacle independence following cataract surgery. However, IOL calculation and selection becomes more complex when presented with previous corneal refractive surgery (CRS) or co-existing corneal conditions. This review explores the use of presbyopia-correcting IOLs in eyes with co-existing corneal conditions or surgically altered corneas.

Using Theory-Based Frameworks to Identify Barriers and Enablers of Physicians' Telemedicine Adoption and Develop Intervention Strategies in China: Multicenter Qualitative Study.

Background: Telemedicine is developing rapidly, presenting new opportunities and challenges for physicians and patients. Limited research has examined physicians' behavior during the process of adopting telemedicine and related factors.

Objective: This study aimed to identify perceived barriers and enablers of physicians' adoption of telemedicine and to develop intervention strategies.

Cellulosic Flexible Electronic Materials: Recent Advances in Structural Design, Functionalization, and Smart Applications.

Rapid advancement of flexible electronics has generated a demand for sustainable materials. Cellulose, a renewable biopolymer, exhibits exceptional mechanical strength, customizable properties, biodegradability, and biocompatibility. These attributes are largely due to its hierarchical nanostructures and modifiable surface chemistry.

Ultrathin Amorphous Iron Oxide Nanosheets for Improving the Electrochemical Performance of Li-S Batteries.

The sluggish kinetics and diffusion of lithium polysulfide (LiPS) intermediates lead to the decline in the capacity and rate of high-energy lithium-sulfur (Li-S) batteries. Integrating adsorbents and electrocatalysts into the Li-S system is an effective strategy for suppressing the polysulfide shuttle and enhancing the redox kinetics of sulfur species. The disordered structure of the electrocatalysts exhibits significantly enhanced catalytic activity.

Insight into the Undesired Racemization of l-Glufosinate during Heating in the Aqueous Phase.

l-glufosinate has garnered increasing attention as an ideal herbicide for weed control in agriculture. However, the underlying racemization process of l-glufosinate in the aqueous phase remains unclear. In this work, we elucidated the racemization mechanisms through heating reactions and theoretical calculations.

Electron-Rich Macrocycle-Based Metal-Organic Frameworks for Efficient Photocatalytic CO Reduction.

Metal-organic frameworks (MOFs) are distinguished by their structural diversity, tunable electronic properties, and exceptional performance in various applications. Notably, the electron-donating ability of ligands significantly enhances the ligand-to-metal charge transfer (LMCT) processes within these frameworks, thereby promoting efficient charge migration. Herein, we developed two electron-rich macrocyclic ligands derived from phenothiazine- and phenoxazine-functionalized calix[3]arenes, alongside their corresponding cobalt-coordinated MOFs.

Profiling the Chemical Exposomic Landscape of Esophageal Squamous Cell Carcinoma.

While the cancer genome is well-studied, the nongenetic exposome of cancer remains elusive, particularly for regionally prevalent cancers with poor prognosis. Here, by employing a combined knowledge- and data-driven strategy, we profile the chemical exposome of plasma from 53 healthy controls, 14 esophagitis and 101 esophageal squamous cell carcinoma (ESCC) patients, and 46 esophageal tissues across 12 Chinese provinces, integrating inorganic, endogenous, and exogenous chemicals. We first show that components of the ESCC chemical exposome mediate the relationship between ESCC-related dietary/lifestyle factors and clinic health status indicators.

Cellulose Acetate Nanofiber and Sodium Alginate-Based Conductive Aerogel for Human Motion Monitoring.

At present, flexible sensors are a hot spot in research and experimental development, but the research on flexible sensors that can be used for human motion monitoring still needs to be deepened. In this work, the green material cellulose acetate (CA) was used as the matrix material, the film was made by electrospinning, crushed by a cell grinder and sodium alginate (SA) was added to promote the uniform dispersion of nanofibers in water, and then methyltrimethoxysilane (MTMS) and MXene nanosheet dispersion were added to make it hydrophobic and good conductivity, and the aerogel precursor solution was prepared, and then the CA/SA/MTMS/MXene aerogel with directional holes was prepared by directional freeze-drying. As a flexible sensor material, it can be used for human wear, monitoring the electrical signals generated by the movement of human joints and other parts, and can still maintain a current of about 0.

Gadolinium-Enhanced Aneurysm Wall Imaging and Risk of Intracranial Aneurysm Growth or Rupture.

Importance: Recent longitudinal studies in patients with unruptured intracranial aneurysms (UIAs) suggested that aneurysm wall enhancement (AWE) on magnetic resonance imaging (MRI) predicts growth and rupture. However, because these studies were limited by small sample size and short follow-up duration, it remains unclear whether this radiological biomarker has predictive value for UIA instability.

Objective: To determine the 4-year risk of instability of UIAs with AWE and investigate whether AWE is an independent predictor of UIA instability.

Stretchable Sensor-Integrated Microfluidic Chip for Monitoring Fatty Acid-Enhanced Serotonin Release from the Intestinal Epithelium.

High-fat foods are decomposed into fatty acids during digestion and absorption, primarily occurring in the gastrointestinal tract, and numerous studies have indicated that long-term high-fat diets significantly increase the incidence of intestinal disorders. As a critical intestinal hormone, serotonin (5-hydroxytryptamine, 5-HT) is involved in regulating intestinal peristalsis, secretion, and visceral sensitivity. However, due to the lack of methods capable of reproducing intestinal mechanical activities and in situ monitoring of 5-HT levels, the influence of high-fat diets on intestinal 5-HT release remains unclear.

An Antibacterial and Electroactive Chitosan-Based Dressing with Dual Stimulus-Responsive Drug Delivery for Wound Healing.

Persistent bacterial infections remain a major challenge in wound management. Although drug-loaded wound dressings have gained increasing attention, their therapeutic efficacy is often hindered by uncontrolled drug release and a lack of electrical signal responsiveness. Herein, an antibacterial dressing (CCS-PC) with electroactivity and stimulus-responsive drug release properties was fabricated via electro-assembly, wherein chitosan and ciprofloxacin hydrochloride (CIP) were co-deposited onto polypyrrole (PPy)-coated gauze.

Downregulation of FOXC1 Modified by METTL3/YTHDF1 Axis Aggravates NLRP3-Mediated Inflammasomes Formation and Cell Pyroptosis in Epilepsy.

Epilepsy is a common chronic nervous system disease that threatens human health. However, the role of FOXC1 and its relations with pyroptosis have not been fully studied in epilepsy. Sprague-Dawley rats were obtained for constructing temporal lobe epilepsy (TLE) models.

Decentralized Clinical Trials in the Era of Real-World Evidence: A Critical Assessment of Recent Experiences.

Since the first decentralized clinical trial (DCT) was conducted in 2011, there has been an increased usage of DCT due to its benefits of patient-centricity and generalizability of findings. This trend was further expedited by the global COVID-19 pandemic. We identified 23 case studies across various therapeutic areas and grouped them into different categories according to their purposes-by necessity, for operational benefits, to address unique research questions, to validate innovative digital endpoints, or to validate decentralization as a clinical research platform.

Association between the uric acid to high-density lipoprotein ratio (UHR) and hypertension in US adults: evidence from NHANES 2005-2020.

Uric acid to HDL ratio (UHR) is a new measure of inflammation that has been widely used to study cardiovascular disease relationships. The aim of this study was to investigate the relationship between uric acid to HDL ratio and hypertension. We found that UHR was positively associated with hypertension prevalence in a nationally representative sample of U.

The Muscle Mass Paradox: Elevated Lean Mass Indices Impair Systolic Function via Myocardial Remodeling in Obesity.

Objectives: To explore the relationships between cardiac parameters and body composition indices, identifying predictors of subclinical cardiac systolic dysfunction.

Methods: Using anthropometric and serological parameters, echocardiography, and body composition analysis, this study evaluated metabolic profiles, cardiac remodeling patterns, and body composition characteristics in young adult obese patients, while quantifying the correlations between cardiac parameters and body composition indices. Subclinical left ventricular systolic dysfunction was defined as global longitudinal strain (GLS) < 18%.

Unveiling Ion-Transport Dynamics in 2D Nanofluidic Anion-Selective Membranes toward Osmotic Energy Harvesting.

Two-dimensional (2D) nanofluidic architectures with nanoconfined interlayer channels and excess surface charges have revolutionized membrane-based reverse electrodialysis systems, demonstrating highly efficient osmotic energy collection through strong electrostatic screening of electric double layer (EDL). However, the ion-transport dynamics in 2D nanofluidic anion-selective membranes (2D-NAMs) still remain unexplored. Here, we combine density functional theory and molecular dynamics (MD) simulations to systematically explore ion transport in the 2D-NAMs.

Unveiling the Ethics of Chinese Biobank: Insights from Consent Document Analysis.

Biobanking in China has seen rapid development, placing the country as a key player globally. However, significant ethical challenges arise, particularly around donor autonomy in informed consent for collecting and using biological materials and personal data. This study examines how Chinese biobanks inform donors about their participation and the ethical content of consent documents.

Validating the Revised Child Anxiety and Depression Scale-Short Version (RCADS-25) in Chinese Preadolescents.

Youth anxiety and depression are rising rapidly worldwide, highlighting the need for efficient school-based assessment tools across sociocultural contexts. The Revised Child Anxiety and Depression Scale (RCADS) is one of the most widely used screening measures, with demonstrated cross-cultural applicability. However, its psychometric properties have rarely been evaluated in Chinese populations.

Hypoxia Aggravates Myocardial Ischemia/Reperfusion Injury Through the Promotion of Ferroptosis via ACSL4 Lactylation.

Myocardial ischemia/reperfusion injury (MIRI) worsens ischemic damage, with ferroptosis as a key mediator of this iron-dependent cell death. Lactylation, a novel epigenetic modification, remains poorly understood in MIRI-associated ferroptosis. This study aimed to elucidate the mechanistic link between lactylation and ferroptosis in MIRI.

Knowledge mapping of plasmacytoid dendritic cells in systemic lupus erythematosus: a bibliometric analysis (2004-2023).

Background: Plasmacytoid dendritic cells (pDCs) are a specialized subset of dendritic cells known for their ability to produce type I interferon (IFN I), contributing to antiviral defense and the pathogenesis of autoimmune diseases like systemic lupus erythematosus (SLE). In SLE patients, pDCs are excessively activated, leading to overproduction of IFN-α, which plays a critical role in disease progression. However, no bibliometric analysis has been conducted on the relationship between pDCs and SLE.