An uncommon complication of dental bridge ingestion: Dual obstructive uropathy and bowel obstruction - Case report.

Introduction And Importance: Foreign body ingestion is a significant clinical concern, particularly among elderly and psychiatric patients, often leading to complications such as intestinal obstruction. In this article, we present an intriguing case of dual intestinal and urinary obstruction caused by the ingestion of a dental bridge in a patient with Bricker urinary diversion. Through this rare case, we aim to explore the diagnostic and therapeutic challenges associated with such incidents, supported by a comprehensive review of the literature.

Case Report: Unveiling the hidden: a rare case of endometrial tuberculosis presenting as peritoneal carcinomatosis.

Background: Endometrial tuberculosis (TB) is a rare form of extrapulmonary TB, particularly uncommon in postmenopausal women. Its atypical presentation, characterized by nonspecific symptoms, often leads to misdiagnosis, particularly when it is confused with malignancies. Moreover, peritoneal tuberculosis, although rare, can further complicate the diagnostic process due to its clinical manifestations that resemble those of various cancerous conditions.

HPV DNA screening and vaccination strategies in Tunisia.

In Tunisia, cervical cancer ranks as the 14th most common cancer, largely driven by high-risk of Human Papillomavirus (HPV) types, notably HPV 16 and 18. Current screening efforts are limited, with only 17% of all women aged 35-60 undergoing Pap-smear testing. The introduction of the HPV vaccine in 2025 through the national school vaccination program, targeting girls aged 11-12, is expected to reduce the burden of cervical cancer.

Prevalence and risk factors of incisional hernia after ileostomy reversal: meta-analysis with meta-regression.

Background: The rate of incisional hernia (IH) at stoma site after ileostomy closure is controversial in the literature. We aimed to estimate the prevalence of IH at stoma site after ileostomy reversal and to determine its risk factors.

Material And Methods: We performed a systematic review according to PRISMA standards to identify studies reporting prevalence of IH after ileostomy closure.

Comprehensive bibliometric and visualized analysis of research on incisional hernia and component separation from 1996 to 2023.

Introduction: In parallel with the increasing number of studies published on component separation technique (CST), there are no bibliometric studies on this subject. This study aimed to report previously published literature in CST to identify the research status.

Methods: A search was undertaken for documents published between 1996 and 2023 from the PubMed, Web of Science, and Scopus databases, using the keywords "incisional hernia" and "component separation.

Contemporary Epidemiology, Management, and In-Hospital Outcomes of Acute Myocarditis: The Prospective Multicenter MyocarditIRM Study.

Background: Despite a frequently favorable evolution during the initial phase, acute myocarditis (AM) remains associated with heart failure and ventricular arrhythmia. There are no large prospective databases to provide robust results.

Objectives: The aim of this study was to describe baseline characteristics, real-life management, in-hospital outcomes, and determinants of prognosis in a large cohort of patients with AM admitted to cardiology, with a comparison of patients with and without initial severity criteria.

180-day efficacy of nirsevimab against hospitalisation for respiratory syncytial virus lower respiratory tract infections in infants (HARMONIE): a randomised, controlled, phase 3b trial.

Background: Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infection and hospitalisations in infants worldwide. The primary analyses of HARMONIE showed that nirsevimab reduced infant hospitalisations due to RSV-associated lower respiratory tract infection through the RSV season. This analysis aims to evaluate nirsevimab's efficacy at 180 days after dosing, a period exceeding the typical 5-month RSV season.

Combination Pharmacotherapy for Benign Prostatic Hyperplasia: Evaluation of Existing Literature on Combination Therapies for Lower Urinary Tract Symptoms Associated with BPH.

Objective: Lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) significantly impact quality of life in aging men. While monotherapies, including alpha-blockers, 5-alpha reductase inhibitors (5-ARI), or phosphodiesterase type 5 inhibitors (PDE5i), are widely used, the potential benefits and risks of combination pharmacotherapies remain less well-documented. This study reviews and assesses the current evidence regarding the use of combination pharmacotherapies in the management of BPH-related LUTS to provide a comprehensive overview of their efficacy and safety profiles.

Assessment of the Prognostic and Predictive Values of the Deficient Mismatch Repair Phenotype in Patients Treated with Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma.

Background And Objective: Given the conflicting evidence currently available in the literature, our aim was to assess the prognostic and predictive values of the deficient mismatch repair (dMMR) phenotype in a large cohort of upper tract urothelial carcinoma (UTUC) patients.

Methods: Based on our national network, we performed a retrospective multicenter study including 281 UTUC patients treated with radical nephroureterectomy between 2000 and 2015 at ten French hospitals. The dMMR phenotype as well as PD-L1 and PD-1 expression were determined using immunohistochemistry analyses based on 2-mm-core tissue microarrays.

Risk factors for postpartum hemorrhage in pregnancies complicated by polyhydramnios.

Objective: To investigate the prevalence and the risk factors for postpartum hemorrhage (PPH) among pregnancies with polyhydramnios.

Methods: We conducted a retrospective single-center study, including all women who presented with polyhydramnios, defined clinically as ≥ 2 L or by ultrasound with an Amniotic Fluid Index >25 cm or a Deepest Vertical Pocket >8 cm, from 2015 to 2022 at the Department of Gynecology and Obstetrics of Rouen University Hospital. We excluded cases of multiple pregnancies and preterm deliveries before 32 weeks of gestation.

Evaluation of transcutaneous electrical tibial nerve stimulation in lower urinary tract dysfunction secondary to a parkinsonian syndrome: Uroparktens-a multicenter randomized placebo-controlled study.

Purpose: Lower urinary tract dysfunction (LUTD) is common in parkinsonian syndromes (PS) and requires special treatment due to limitations in the use of certain drugs and the progression of the disease. Tibial nerve stimulation by transcutaneous electrical nerve stimulation (TENS) is a simple, well-tolerated treatment with proven effectiveness in LUTD. The aim of our study was to evaluate the efficacy on urinary symptoms in patients with a parkinsonian syndrome.

Colic ameboma mimicking colic cancer: A case report.

Introduction: Amoebic colitis, caused by the protozoan Entamoeba histolytica, is a significant global health concern, ranking as the second leading cause of parasitic infection-related mortality. The disease manifests across a wide clinical spectrum, from asymptomatic carriers to severe necrotizing colitis. Rarely, it can form an inflammatory mass, or ameboma, which may mimic malignancy.

Diagnosing and Managing Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Adults: Review of Evidence 2017-2023.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening reactions associated with long-term disabling sequelae. In the acute phase, the best supportive care in expert centers is the cornerstone of treatment. The follow-up is prolonged and multidisciplinary, according to the patient's needs.

The effect of pre-existing sarcopenia on outcomes of critically ill patients treated for COVID-19.

Background: Sarcopenia, defined by a loss of skeletal muscle mass and function, has been identified as a prevalent condition associated with poor clinical outcome among critically ill patients. This study aims to evaluate the impact of pre-existing sarcopenia on outcomes in critically ill patients with acute respiratory failure (ARF) due to COVID-19.

Material And Methods: A retrospective study was carried out on COVID-19 patients admitted to intensive care.

Discarded intravenous medication in the ICU: the GAME-OVER multicenter prospective observational study.

Background: Medication waste is a contributor to the healthcare environmental footprint and impacts ecosystems. Data on medication waste in the intensive care unit (ICU) are scarce, and therefore are essential to develop new sustainable strategies.

Methods: The GAME-OVER French multicenter prospective observational study was conducted from November 2022 to March 2023, over a 24-h period of choice, at the discretion of each participating center.

PTP1B AND ZONULIN FAILED TO PREDICT THE MODIFICATION OF MUSCLE MASS IN CRITICALLY ILL PATIENTS WITH SEPTIC SHOCK.

Background: Proteolyse is one of the causes of loss of lean body mass, and depend of insulin. Proteintyrosine phosphatase 1B (PTP1B) and intestinal permeability (evaluated by zonulin) contribute of insulin metabolism. The objectives were to explore the relationship between PTP1B, zonulin level and body composition during septic shock in humans.

Initial and recurrent management of parastomal hernia after cystectomy and ileal conduit urinary diversion: a 10 year single-center experience.

Purpose: The management of parastomal hernia following cystectomy and ileal conduit diversion is challenging due to its specific nature and a high recurrence rate, yet is poorly described.

Methods: We retrospectively searched the clinical data warehouse of our center for patients who had primary parastomal hernia repair following cystectomy and ileal conduit diversion. The primary endpoint was recurrence of parastomal hernia; secondary endpoints were postoperative complications and surgical management of recurrences.

Impact of an early educational protocol on the oral language of children born preterm exhibiting phonological fragility: a multicenter randomized clinical trial.

Unlabelled: We conducted a six-center, prospective, randomized, open-label trial to assess whether an early standardized educational protocol provided from 42 to 48 months of age improved the progression of oral language and phonological development in children born preterm. A total of 552 children with phonological fragility were included in this study. The children were randomized to receive the educational protocol (guided arm,  = 87) or not (non-guided arm,  = 78).

Risk of metachronous peritoneal metastases after surgery for obstructive colon cancer: Multivariate analysis from a series of 1,085 patients.

Background: Data in the literature suggest that obstruction is an independent predictor of poor prognosis in colon cancer. Of all possible sites of recurrence, peritoneal metastases are associated with worse survival. Our aim was to report the incidence of metachronous peritoneal metastases from a cohort of patients undergoing resection of obstructive colon cancer with curative intent and to identify predictive factors for metachronous peritoneal metastases.

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Introduction: In their practice, pharmacists are confronted with situations that may pose ethical problems. They must make decisions based on scientific knowledge as well as the principles of bioethics.

Aim: To evaluate pharmacists' attitudes towards specific ethical dilemmas.

Prevalence and Risk Factors of Bronchopulmonary Dysplasia Among Very Premature Infants in a Tunisian Neonatal Intensive Care Unit.

Introduction: Bronchopulmonary dysplasia (BPD) stands as the primary chronic respiratory complication in premature infants, posing a substantial public health concern due to its rising prevalence, potential mortality, and socioeconomic burden.

Aim: The aim of this study was to determine the prevalence of BPD in very preterm infants and identify its associated risk factors.

Methods: We conducted a retrospective, descriptive, and analytical study including all premature infants born between 26 and 31 weeks of gestation age (GA) who survived beyond the 28th day of life, over a five-year period (2017-2021).