Clinical and metabolic phenotyping of continuous versus intermittent ENteral NUTrition in ventilated adults with shock: ENNUT trial protocol.

Introduction: Critically ill patients often require enteral nutrition, but the optimal feeding strategy-continuous or intermittent-remains uncertain. While continuous enteral nutrition ensures steady nutrient delivery, it may inhibit key metabolic and cellular processes such as autophagy and ketogenesis. Intermittent enteral nutrition, by mimicking fasting periods, could activate protective pathways, potentially improving clinical outcomes.

An increase in skin blood flow after red blood cell transfusion is associated with an improvement in organ function in critically ill patients.

Introduction: Red blood cell transfusions (RBCTs) are administered to critically ill patients to enhance tissue oxygen delivery. We investigated whether an increase in skin blood flow (SBF), a proxy for tissue perfusion, after RBCT was associated with improved organ function in non-bleeding intensive care unit (ICU) patients.

Methods: This secondary analysis of a prospective cohort included 175 adult ICU patients without acute bleeding who received a RBCT.

Evaluating local ischemic preconditioning effects on skin perfusion using capillary refill time in healthy volunteers.

Capillary refill time (CRT) is a vaso-occlusive test that allows the non-invasive assessment of skin perfusion. A vascular occlusive test (VOT) induces transient ischemia similar to that used in preconditioning ischemia. We hypothesized that CRT could be influenced by local tissue compression mimicking ischemic preconditioning when repeated measurements are performed.

Validation of the SHELTER score after aneurysmal subarachnoid hemorrhage cohort: An observational retrospective study.

Objective: Early brain injury (EBI) following aneurysmal subarachnoid hemorrhage (aSAH) occurs in the first 3 days after bleeding is associated with long-term complications and poor neurological outcomes. The aim of this study was to externally validate the SHELTER score, which has been developed to quantify the severity of EBI.

Methods: This is a retrospective single center study of adult aSAH patients consecutively admitted to the Intensive Care Department of Hôpital Universitaire de Bruxelles between January 2015 and December 2023.

Ivabradine use in critical care: a systematic review and metanalysis of cardiogenic and septic shock patients.

Introduction: In patients with acute illness, compensatory tachycardia initially serves to maintain adequate cardiac output, oxygen delivery and tissue oxygenation but may persist despite appropriate fluid and vasopressor resuscitation or may be secondary to inotropic therapy. Sustained tachycardia is a predictor of adverse outcomes in critical illness. Ivabradine, a highly selective inhibitor of the sinoatrial node's pacemaker current (I or "funny" current), mitigates tachycardia by modulating diastolic depolarization slope without affecting contractility.

The effect of pre-existing sarcopenia on outcomes of critically ill patients treated for COVID-19.

Background: Sarcopenia, defined by a loss of skeletal muscle mass and function, has been identified as a prevalent condition associated with poor clinical outcome among critically ill patients. This study aims to evaluate the impact of pre-existing sarcopenia on outcomes in critically ill patients with acute respiratory failure (ARF) due to COVID-19.

Material And Methods: A retrospective study was carried out on COVID-19 patients admitted to intensive care.

PTP1B AND ZONULIN FAILED TO PREDICT THE MODIFICATION OF MUSCLE MASS IN CRITICALLY ILL PATIENTS WITH SEPTIC SHOCK.

Background: Proteolyse is one of the causes of loss of lean body mass, and depend of insulin. Proteintyrosine phosphatase 1B (PTP1B) and intestinal permeability (evaluated by zonulin) contribute of insulin metabolism. The objectives were to explore the relationship between PTP1B, zonulin level and body composition during septic shock in humans.

Understanding metabolic remodeling in shock through metabolomics lenses.

The management of shock in critical care must transition from a predominantly hemodynamic approach to one that comprehensively addresses the biological intricacies of this complex multisystemic syndrome. A thorough understanding of the metabolic mechanisms involved in shock is pivotal for precise patient phenotyping and accurate risk stratification. Metabolomics, an emerging "-omics" approach, offers a powerful tool for unraveling the molecular underpinnings of shock.

Social Media Usage for Medical Education and Smartphone Addiction Among Medical Students: National Web-Based Survey.

Background: Social media (SoMe) have taken a major place in the medical field, and younger generations are increasingly using them as their primary source to find information.

Objective: This study aimed to describe the use of SoMe for medical education among French medical students and assess the prevalence of smartphone addiction in this population.

Methods: A cross-sectional web-based survey was conducted among French medical students (second to sixth year of study).

Targeting NETosis in Acute Brain Injury: A Systematic Review of Preclinical and Clinical Evidence.

Acute brain injury (ABI) remains one of the leading causes of death and disability world-wide. Its treatment is challenging due to the heterogeneity of the mechanisms involved and the variability among individuals. This systematic review aims at evaluating the impact of anti-histone treatments on outcomes in ABI patients and experimental animals and defining the trend of nucleosome levels in biological samples post injury.

Soluble TREM-1 plasma levels are associated with acute kidney injury, acute atrial fibrillation and prolonged ICU stay after cardiac surgery- a proof-concept study.

Background: Cardiopulmonary bypass (CPB) during cardiac surgery leads to deleterious systemic inflammation. We hypothesized that TREM-1, a myeloid receptor shed after activation, drives systemic inflammation during CPB.

Methods: Prospective observational bi-centric study.

Ventriculo-arterial (un)coupling in septic shock: Impact of current and upcoming hemodynamic drugs.

Sepsis is an archetype of distributive shock and combines different levels of alterations in preload, afterload, and often cardiac contractility. The use of hemodynamic drugs has evolved over the past few years, along with the invasive and non-invasive tools used to measure these components in real time. However, none of them is impeccable, which is why the mortality of septic shock remains too high.

Evaluation of Medical Confidentiality Breaches on Twitter Among Anesthesiology and Intensive Care Health Care Workers.

Background: With the generalization of social network use by health care workers, we observe the emergence of breaches in medical confidentiality. Our objective was to determine, among anesthesiology and intensive care health care workers, the rate of medical confidentiality breaches among professional tweets.

Methods: We performed a retrospective analysis of public Twitter data available through the official Twitter application program interface.

Gender differences in professional social networks use among critical care researchers.

Background: Recent studies highlight that female anaesthesiology researchers have lower visibility on professional social networks (PSNs) than male researchers.

Objective: The objective of this work was to compare the use of PSNs between women and men in critical care research.

Methods: We included the first/last authors (FAs/LAs) among the most frequently cited articles in 2018 and 2019 in three critical care journals (Intensive Care Medicine, Critical Care Medicine, and Critical Care).

Point-of-Care Viscoelastic Hemostatic Assays in Cardiac Surgery Patients: Comparison of Thromboelastography 6S, Thromboelastometry Sigma, and Quantra.

Objectives: Viscoelastic tests allow a reduction in blood product transfusion. Three modern devices are currently available (rotational thromboelastometry [ROTEM] sigma, thromboelastography [TEG] 6S, and Quantra). No study has compared the performances of these 3 devices simultaneously.

Effect of mechanical ventilation during cardiopulmonary bypass on end-expiratory lung volume in the perioperative period of cardiac surgery: an observational study.

Background: Many studies explored the impact of ventilation during cardiopulmonary bypass (CPB) period with conflicting results. Functional residual capacity or End Expiratory Lung Volume (EELV) may be disturbed after cardiac surgery but the specific effects of CPB have not been studied. Our objective was to compare the effect of two ventilation strategies during CPB on EELV.

Women's visibility at European Society for Clinical Nutrition and Metabolism congresses from 2011 to 2019: Is the floor yours?

Purpose: Participating in international conferences is an essential way to promote scholarly work. We aimed to assess the trend of women's visibility at the European Society for Clinical Nutrition and Metabolism (ESPEN) congress by describing the evolution of the proportion of women speakers between 2011 and 2019.

Materials And Methods: This is a retrospective study including public data obtained from the 2011, 2015, and 2019 ESPEN congresses.

Soluble RAGE as a Prognostic Marker of Worsening in Patients Admitted to the ICU for COVID-19 Pneumonia: A Prospective Cohort Study.

Background: The different waves of SARS-CoV-2 infection have strained hospital resources and, notably, intensive care units (ICUs). Identifying patients at risk of developing a critical condition is essential to correctly refer patients to the appropriate structure and to spare limited resources. The soluble form of RAGE (sRAGE), the endoplasmic stress response and its surrogates, GRP78 and VEGF-A, may be interesting markers.

Reliability of the Minto model for target-controlled infusion of remifentanil during cardiac surgery with cardiopulmonary bypass.

Background: The Minto pharmacokinetic model is used for target-controlled infusion of remifentanil. The reliability of this model has never been evaluated during normothermic cardiac surgery with cardiopulmonary bypass (CPB). The aim of this study was to assess the predictive performance of the model during CPB to determine its reliability during cardiac surgery.

The Perception of the Anesthesiologist Among the Medical, Paramedical and Administrative Staff.

Introduction: Anesthesia remains a young medical discipline still relatively unknown by the general public and probably by some health professionals. The objective of the study was to evaluate the perception of anesthesiologist by health professionals working with this specialty.

Methods: We distributed a computerized survey to physicians, residents, paramedical, midwives, and administrative staff in different hospitals between April and July 2018 in Normandy, France.

The Association Between Professional Accounts on Social Networks Twitter and ResearchGate and the Number of Scientific Publications and Citations Among Anesthesia Researchers: Observational Study.

Background: Social networks are now essential tools for promoting research and researchers. However, there is no study investigating the link between presence or not on professional social networks and scientific publication or citation for a given researcher.

Objective: The objective of this study was to study the link between professional presence on social networks and scientific publications/citations among anesthesia researchers.

Myeloid phenotypes in severe COVID-19 predict secondary infection and mortality: a pilot study.

Background: De-regulated host response to severe coronavirus disease 2019 (COVID-19), directly referring to the concept of sepsis-associated immunological dysregulation, seems to be a strong signature of severe COVID-19. Myeloid cells phenotyping is well recognized to diagnose critical illness-induced immunodepression in sepsis and has not been well characterized in COVID-19. The aim of this study is to review phenotypic characteristics of myeloid cells and evaluate their relations with the occurrence of secondary infection and mortality in patients with COVID-19 admitted in an intensive care unit.

A Weak Response to Endoplasmic Reticulum Stress Is Associated With Postoperative Organ Failure in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass.

Endoplasmic reticulum stress (ERS) is involved in inflammatory organ failure. Our objective was to describe ERS, its unfolded protein response (UPR) expression/kinetics during cardiac surgery with cardiopulmonary bypass (CPB) and its association with postoperative organ failure (OF). Prospective study conducted on patients undergoing cardiac surgery with CPB.

Gender differences in professional social media use among anaesthesia researchers.

Background: Recent studies suggest that female researchers are less visible on social media. The objective of this observational work was to compare the use of professional social networks between male and female anaesthesia researchers.

Methods: Among four anaesthesia journals, we analysed the first/last authors (FA/LA) of the most frequently cited articles in 2016-2017 and the authors who published more than one article per year between 2013 and 2018 (prolific authors).