Sustainable Solutions From Silkworms: Antheraea assamensis Helfer Oil Regulates Oxidative Stress, Lipid Metabolism, and Liver Health-Navigating Future Food Challenges.

Silkworms are emerging as a sustainable food source to address global food security, with their proteins recognized for nutritional and medicinal benefits. However, the impact of silkworm oil on immunological and pharmacological effects remains unexplored. This study explores the effects of the muga (Antheraea assamensis Helfer) silkworm pupal oil fraction (MP) on palmitic acid (PA) induced hepatic steatosis, inflammation, and oxidative stress.

Eco-friendly biopolymers and their biomedical applications: A review.

This review explores commonly used biopolymers in wound dressings, highlighting their significance, limitations, and structural modifications that enhance their suitability for biomedical applications. It examines the role of biopolymers in biomedical fields, particularly in cell attachment and tissue engineering, discussing the interaction between cells and artificial surfaces, the mechanisms of cell attachment, and factors influencing cell adhesion. The advanced wound dressing materials that are multifunctional have been discussed.

Advancements in two-dimensional boron nitride nanostructures: properties, preparation methods, and their biomedical applications.

Novel boron nitride (BN) nanostructures with varied dimensionalities and unique and extraordinary qualities like exceptional mechanical properties, high thermal conductivity, excellent chemical properties have applications in diverse and promising fields, encompassing healthcare, environment, and energy. Amongst the boron nitride nanostructures, two-dimensional BN sheets have been extensively explored by researchers due to their planar topography, which confers them with distinct qualities in terms of chemical, physical, optical, and electronic properties. 2D boron nanostructures have a significant surface-to-volume ratio that enables their enhanced contact with cells and biomolecules, making them appealing candidates for biological applications.

Sesquiterpene metabolites from Pogostemon cablin leaf essential oil as acetylcholinesterase inhibitors: An integrated computational and phytochemical study.

Neurological disorders are the major factor of dementia worldwide, presenting significant and escalating challenges to global healthcare systems. Alzheimer's disease (AD) is a leading cause of dementia, creating substantial challenges for international healthcare. Medicinal and aromatic plants offer diverse pharmaceutical properties owing to their richness in chemical constituents.

Co-pyrolysis of garlic (Allium sativum L.) straw and polyethylene waste through thermogravimetric analysis: Assessing synergistic effects in terms of kinetic and thermodynamic analyses.

In this work, pyrolysis of garlic straw (GS) and co-pyrolysis of GS and polyethylene (PE) is studied, comprising observations of mass loss at various stages of devolatilization, possible synergistic effects, estimation of kinetic and thermodynamic parameters, and reaction mechanism.Blending of PE with GS resulted in an increase in heating value of the feedstock, improving it from 15.57 MJ/kg to 29 MJ/kg.

Macroalgal (seaweed) derived bioplastic as a sustainable food packaging material - A critical review.

Macroalgae, commonly known as seaweed, are renewable and abundant marine resources that have gained popularity over the past few years due to their potential to produce bioplastics with unique properties. This review provides a comprehensive overview of recent advances in the development, processing, and application of seaweed-derived bioplastics, emphasizing their film-forming ability, renewable origin, and favourable physicochemical characteristics that position them as promising sustainable alternatives to petroleum-based plastics in food packaging. Furthermore, a comprehensive overview of their different extraction methods, including conventional and advanced techniques, is also summarized.

Therapeutic Uses of Dietary Organosulfur Compounds in Response to Viral (SARS-CoV-2)/Bacterial Infection, Inflammation, Cancer, Oxidative Stress, Cardiovascular Diseases, Obesity, and Diabetes.

Phytonutrients are widely recognized for their protective health benefits in humans. Mounting studies suggest that dietary organosulfur compounds play a significant role in preventing various pathological conditions. Organosulfur compounds, such as diallyl disulfide, diallyl trisulfide, alliin, allicin, S-allyl cysteine, and sulforaphane, possess broad pharmacological activities, making them versatile therapeutic agents.

Interface-driven Pd-Ag-Cu/C nanocomposites with increased oxygen reduction reaction kinetics.

Highly dispersed PdAgCu/C nanocomposites with enhanced catalytic activity and stability were synthesized a solvothermal method. Structural characterization confirms the formation of a multimetallic nanocomposite consisting of well-distributed Pd, Ag and Cu domains on the carbon support. The close proximity of these metal domains facilitates interface-driven electronic modulation, which contributes to improved oxygen reduction reaction (ORR) kinetics.

Synergistic micro-phyto-vermi remediation: Integrated bioprocess approach for sustainable treatment of petroleum contaminated soil and industrial oily sludge.

Petroleum waste pollution presents a major environmental challenge, highlighting the need for sustainable and efficient remediation strategies. Bioremediation has emerged as a promising eco-friendly solution that utilizes microbial communities to degrade harmful hydrocarbons. Among various bioremediation approaches, composting is an established organic waste treatment method that has been effectively adapted for managing petroleum-contaminated sludge.

Heteroatom Doping, Defect Engineering, and Stability of Transition Metal Diselenides for Electrocatalytic Water Splitting.

Designing stable and efficient catalysts for water electrolysis has been a crucial challenge in developing technologies for the sustainable production of hydrogen. So far, various metal-based nanomaterials have been reported as promising electrocatalysts for driving the water-splitting reaction. Among them, transition metal diselenides (TMDSes) have garnered significant attention owing to their unique layered and non-layered structure, tunable electronic properties, and intrinsic catalytic activity.

CuS-MIL-53(Fe) Framework as a Heterogeneous Fenton Catalyst for the Removal of Organic Contaminants.

Developing a suitable Fenton catalyst capable of efficient redox cycling between Fe and Fe for dye degradation is a promising approach for enhancing catalytic activity. In this work, we synthesized a rod-like CuS-MIL-53(Fe) framework via a solvothermal process. The incorporation of CuS into pristine MIL-53(Fe) induced a significant structural transformation from an octahedral to a rod-like morphology, resulting in an enhanced surface area from 130.

Phytochemical profiling and in vitro biological activity evaluation of Lavandula angustifolia flower essential oil.

Lavandula angustifolia is an economically important plant containing essential oil. In the present study, the chemical composition, biological activities and genotoxicity of Lavendula angustifolia flower essential oil (LAFEO) were investigated. The essential oil was extracted using a Clevenger-type apparatus and subsequently analyzed for its biological activities.

Synthesis of Gold Nanoparticle-Decorated Borophene (Au@BNSs) Nanozymes with Glucose Oxidase and Peroxidase Activity for Colorimetric Detection of Glucose.

The inherent reducing properties of borophene nanosheets (BNSs) were harnessed to facilitate the reduction of gold ions, leading to the synthesis of gold nanoparticle-decorated borophene nanosheets (Au@BNSs) via an eco-friendly, green approach and eliminating the need for toxic external reducing agents. This innovative synthesis method addresses the limitations of conventional glucose monitoring systems, which often rely on expensive reagents and sophisticated equipment. The synthesized Au@BNSs nanocomposite demonstrated dual enzyme-mimetic activity, replicating both glucose oxidase (GOx) and peroxidase (POD) and facilitating efficient colorimetric glucose detection.

In Vitro and In Silico Approaches to Exploring the Potential Therapeutic Effects of Curcuma amada Rhizome Essential Oil.

Curcuma amada (mango ginger) is a medicinal herb valued for its traditional uses and pharmacological properties. This study investigates the essential oil (EO) from C. amada rhizome (Curcuma amada rhizome EO [CAREO]), highlighting its anti-microbial, anti-diabetic, and anti-inflammatory activities through in vitro and in silico methods.

Safety Profiling of Borophene Nanosheets: and Toxicity Investigations.

Like graphene, a well-established two dimentional (2D) material with extensive biomedical applications, borophene holds significant promise in this field. However, toxicological evaluations are crucial to establish its biosafety. The study presents cytotoxicity of borophene nanosheets (BNSs) in cancer cells and animal blood samples and toxicity studies in laboratory rats for the first time.

A systemic investigation of the phytochemical space in polyherbal formulations of India: A curated database.

Medicinal plants have been the baseline of traditional medical practices across the globe. The traditional remedies practiced in India have been documented in ancient books from 5000 years BC. This study presents a systematic investigation of the phytochemical landscape of Indian polyherbal formulations curated from scientific literature.

Exploring graph-based models for predicting active compounds against triple-negative breast cancer.

Breast cancer is among the most dominant and rapidly rising cancers, both in India and around the world. Triple-negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer, distinguished by the absence of HER2, progesterone, and estrogen receptor expressions. This absence limits treatment options, emphasizing the urgent need to discover or design new drug candidates for TNBC.

Interfacial Engineering of 2D-2D CdInS/TiC Heterojunctions for Enhanced Photocatalytic Hydrogen Generation.

Utilization of solar energy through wireless water-splitting technology offers a promising pathway toward a sustainable and environmentally conscious future. The rational design of 2D-2D heterojunctions leverages synergistic effects to optimize charge carrier dynamics, thereby boosting photocatalytic activity. In this study, well-engineered heterojunction TiC/CdInS (TCIS) nanocomposites are synthesized via an in situ hydrothermal method and employed in photocatalytic hydrogen evolution (PHE).

2D nanozymes: bioinspired innovations for healthcare and environmental applications.

Natural enzymes play a pivotal role in catalyzing essential biochemical reactions in both and systems, owing to their exceptional catalytic efficiency, substrate specificity, and biocompatibility. However, their widespread application is significantly limited by inherent drawbacks such as high production costs, limited operational stability, and poor reusability. In response, two-dimensional (2D) nanomaterials, such as graphene, borophene, hexagonal boron nitride (h-BN), transition metal dichalcogenides (TMDs), and MXenes, have emerged as a novel class of enzyme mimetics, or nanozymes, offering distinct advantages due to their atomic thickness, high surface-to-volume ratio, and tunable electronic and physicochemical properties.

Development of Dry Powder Inhaler formulation for site specific delivery of nanoconjugates loaded with Curcumin and BCL2 siRNA in Lung Cancer.

Lung cancer remains one of the leading causes of cancer-related deaths, with current chemotherapy limited by poor drug delivery, toxicity, and resistance. To overcome these challenges, we developed a dry powder inhaler (DPI) system incorporating a PLGA-PEG-LHRH (PPL) nanoconjugate (NC) for enhanced delivery. Curcumin (CUR), with known anticancer and P-gp inhibition properties, was co-loaded with bcl2 siRNA (bclsR) to target bcl2 protein and combat resistance mechanisms.

Manifesting p-d Orbital Hybridization Through Strategic D-Band Engineering: A Pathway to Boosted Bifunctional HER/OER Electrochemical Performance in Self-Templated Co-SnO Grown Over Co-SnS Nanosheets.

In this study, Co-doped SnO is synthesized atop the hexagonal CoS template (CoSS) via direct air calcination of as-synthesized Co-doped SnS (CoS) nanosheets. The structural evolution facilitated the emergence of Co and Co states, complemented by surface-adsorbed sulfur oxyanions (SO , HSO , SO ). CoSS deposited over carbon cloth (CoSS/CC) exhibited superior bifunctional HER and OER, demonstrating higher stability and efficiency than their CoS/CC counterparts.

Photoresponsive Ferrocene- Augmented Iridium Polypyridyl Complex as an Oxidase Mimic for Selective Glutathione Sensing: Implications for Cancer Diagnostics and Therapy.

The enzyme-mimic activity of a well-defined structurally characterized organometallic complex, [Ir(ppy)₂(fcbpy)]PF₆(1; ppy = 2-phenylpyridine; fcbpy = 4-ferrocenyl-2,2'-bipyridine), a bimetallic iridium-polypyridyl complex is investigated under light irradiation for the first time. This complex exhibits an extended excited-state lifetime of 592 ns due to bimetallic synergy, and possess oxidase-mimic activity in the presence of light. Leveraging this light-activated oxidase-mimic activity, a simple colorimetric assay is developed that successfully differentiates cancerous cells from normal cells, based on elevated glutathione (GSH) levels.

Smart-Sandwich: A Thin Flexible Sensing Device Based on an Agarose-Chitosan-Agarose (ACA) Triple-Layer Biofilm for Onsite Monitoring of .

Portable, cost-effective, and durable thin-film sensors are essential for real-time detection, ensuring safe drinking water and public health protection. In this work, we developed a solid-state, flexible sensing device using an agarose-chitosan-agarose (ACA) sandwich biofilm for the selective colorimetric detection of in water. The chitosan in ACA biofilm functions as an artificial enzyme, exhibiting peroxidase-like activity, which catalyzes the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (HO).

Enhanced glucose regulation potential of C-peptide mimics.

The connecting peptide (C-peptide), once relegated as an epiphenomenon in insulin biosynthesis, has now been recognized for its capacity to instigate molecular effects along with important physiological functions. These findings suggest that C-peptide is a hormonally active molecule responsible for controlling a number of diabetes-related complications, in addition to proinsulin processing. Notably, it demonstrates cellular responsiveness and acts as a robust biomarker for beta cell functions, with a half-life longer than that of insulin.

Ultrasound triggered process optimization of Etlingera linguiformis (Roxb.) R.M.Sm. nanoemulsion: Its stability, cytotoxicity and antibacterial activity.

Periodontal infections and dental caries are leading causes of tooth loss, impacting overall health and quality of life. Conventional treatments involve antibiotics, antiamoebic drugs, and quaternary ammonium compounds, their prolonged use can cause resistance and toxicity. In this study, E.