NUTM2A-AS1 as a potential key regulator in cancer: unraveling its ceRNA networks and impact on tumor biology.

NUTM2A-AS1 is an emerging long noncoding RNA (lncRNA) that has garnered significant attention due to its multifaceted roles in cancer biology. As a member of the ceRNA network, NUTM2A-AS1 modulates gene expression by sequestering microRNAs, thereby influencing key oncogenic pathways. This review aims to provide a comprehensive overview of the current understanding of NUTM2A-AS1 in the development, progression, and metastasis of various cancers, including gastric cancer, hepatocellular carcinoma, neuroblastoma, colorectal cancer, glioma, lung adenocarcinoma, prostate cancer, and renal cell carcinoma.

Biochemical, physiological and phenotypic variation in Ocimum Basilicum L. cultivars under salt stress conditions.

Background: Basil (Ocimum basilicum L.), a globally significant medicinal plant of the Lamiaceae family, contains valuable volatile oils, polyphenols, and flavonoids with wide applications in food, pharmaceutical, and cosmetic industries. This study evaluated salinity stress responses across 13 basil cultivars, quantifying growth, morphological, and biochemical changes under 90 mM NaCl.

First Report of MPL c.23T>G (p.M8R) Variant in Congenital Amegakaryocytic Thrombocytopenia: A Case Report.

Congenital amegakaryocytic thrombocytopenia is a rare inherited bone marrow failure syndrome primarily caused by MPL gene mutations. It presents with severe neonatal thrombocytopenia and typically progresses to pancytopenia. We report the first disease-associated case of the MPL variant c.

Association of Salivary Microbial, Fungal Population and Salivary Acidity with Obesity in Children.

Background: Childhood obesity is an increasing global health concern associated with both systemic and oral complications. While studies suggest links between body mass index (BMI) and oral health markers, these relationships remain poorly defined.

Purpose: This study evaluated the association between salivary microbial/fungal populations, salivary acidity, and obesity in children.

Urticaria as a dermatologic manifestation of Giardia infection: a systematic review of clinical, diagnostic, and therapeutic features.

Background: Giardiasis is recognized as the most prevalent enteric protozoal infection worldwide. Although gastrointestinal symptoms are the most common manifestations of giardiasis, several studies have reported cases of urticaria associated with this infection. Urticaria is a common mast cell-dependent disorder characterized by wheals, angioedema, or both.

3D printed antibacterial and anti-inflammatory scaffold containing vanillin-loaded Soluplus nanomicelles for healing of infected wounds.

Treating infected wounds is a major clinical challenge, and concerns about bacterial resistance have driven the shift toward natural antimicrobials over antibiotics. Herein, a 3D printed scaffold wound dressing consisting of alginate (Alg) and fucoidan (F) was prepared, and Soluplus (Sol) nanomicelles (NMs) were used to load vanillin (Vn) as a lipophilic antibacterial agent into the 3D printed scaffold. Characterization analyses revealed that the fabricated scaffold exhibited a peak swelling capacity of 294.

Bismuth Oxide Nanoparticles-Induced Subclinical Nephrotoxicity in Male Mice: Role of Oxidative Stress and Apoptosis.

Bismuth's unique properties have led to its widespread use in medical, cosmetic, and electronic applications. However, increasing evidence suggests potential toxicity, particularly from nanoparticle forms that may accumulate in organs. This study investigated the nephrotoxic effects of bismuth oxide nanoparticles (Bi₂O₃ NPs) in male NMRI mice, focusing on underlying molecular mechanisms.

Fabrication, characterization and in vitro evaluation of PCL/PVA nanofibers loaded with docetaxel in breast cancer cells.

Breast cancer ranks as the second highest cause of mortality among women, and docetaxel (DTX) is a potent anticancer agent whose therapeutic effects can be optimized using nanofibers (NFs)-based drug delivery systems (DDSs). In this study, DTX-loaded NFs were fabricated using polycaprolactone (PCL) and polyvinyl alcohol (PVA) electrospinning. Scanning electron microscopy (SEM) revealed smooth, bead-free morphology with random fiber orientation.

Carbohydrate antigen 125 and clinical outcomes in heart failure: systematic review and meta-analysis.

Introduction: Carbohydrate Antigen 125 (CA125) has emerged as a potential biomarker in patients with heart failure (HF). This meta-analysis comprehensively evaluates the association between CA125 levels and clinical outcomes across HF populations.

Methods: We conducted this study based on the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA).

Optimal dietary arginine improves productive performance, gut morphology, and expression of growth-related and stress-response genes in Japanese quails.

This research examines the impact of different dietary arginine (Arg) concentrations on growth performance, carcass traits, gut morphology, and gene expression in Japanese quails aged 1 to 35 days. A total of 600 Japanese quail chicks were randomly allocated to five dietary treatments consisting of 0.75%, 1.

Forecasting climate change effects on the potential distribution of Zhumeria Majdae as an endangered monotypic endemic species: a maxent modeling approach.

Medicinal plants are invaluable sources of bioactive compounds and continue to serve as primary medicine for many people worldwide, despite advances in pharmaceuticals. Their recognition has increased with the popularity of herbal products, yet many are vanishing rapidly. Climate change further threatens these resources, making their conservation a pressing concern.

The supplemental LED light spectra and silicon foliar application alleviate the adverse effects of combined salinity-alkalinity stress on Physalis angulata.

This study examined the interactive effects of supplemental LED (Light-emitting diode) lighting and foliar silicon application on the growth, physiology, and nutrient status of Physalis angulata under different levels of salinity-alkalinity stress in a hydroponic system. Plants were exposed to three stress levels (control, moderate, severe), two silicon concentrations, and four light regimes (natural, blue: red, red, blue). Salinity-alkalinity stress significantly reduced plant height, stem diameter, leaf area, shoot and root biomass, and physiological characteristics, but these negative effects were alleviated by silicon and LED treatments.

The Multi-Voxel MRS of Glioma: Glycine is a Suitable Biomarker for Tumor Grading.

Background: The goal of this study was to evaluate the role of different metabolites such as glycine, choline (Cho), NAA, and creatinine (Cr) in the grading of glioma in the multi-voxel MRS.

Materials And Methods: Thirty-five patients who suffered from glioma, according to their pathologic and clinical findings, were included in this study. In this work, the paraffin-embedded brain tissues of patients were studied by four expert pathologists.

Investigation of predictive factors for fatty liver in children and adolescents using artificial intelligence.

Background: Childhood obesity is a growing problem worldwide, leading to non-alcoholic fatty liver disease (NAFLD), which is the most common liver disease in children. Liver biopsy is the gold standard for NAFLD diagnosis. Machine learning algorithms could assist in an early diagnostic approach and leading to a favorable prognosis.

Comparative Analysis of Shear Bond Strength of Four Adhesive Systems on Primary Dentin.

Objective: This study aimed to conduct a comparative evaluation of the shear bond strength of etch and rinse (Single Bond 2), two-step self-etch (Clearfil SE) and one-step self-etch (Go Bond SDI and G-Premio Bond) bonding agents applied to primary teeth, using a universal testing machine.

Material And Methods: The sample was divided into four groups: Group A incorporated Single Bond 2, Group B constituted Clearfil SE, Group C constituted Go Bond SDI, and Group D constituted G-Premio Bond. In each group, 14 out of the total 56 primary canine teeth were considered.

Retraction notice to 'The effects of vitamin D and probiotic co-supplementation on glucose homeostasis, inflammation, oxidative stress and pregnancy outcomes in gestational diabetes: A randomized, double-blind, placebo-controlled trial' [Clinical Nutrition 38 (2019) 2098-2105].

This article has been retracted: please see Elsevier policy on Article Correction, Retraction and Removal (https://www.elsevier.com/about/policies-and-standards/article-withdrawal).

The interactions of natural compounds with Escherichia coli motility, attachment, communication systems, and mature biofilm.

Bacterial biofilms play a significant role in increasing antibiotic resistance and the pathogenesis of Escherichia coli; their control is a major challenge in treating bacterial infections. In recent years, natural compounds have emerged as effective alternatives for inhibiting the formation and destruction of bacterial biofilms. Natural compounds such as curcumin, cinnamaldehyde, eugenol, carvacrol, quercetin, resveratrol, thymol, citral, and catechin are noteworthy in hindering and destroying E.

Phosphorus has a crucial role in growth performance of calves fed starters with incorporated forage.

Forage addition (FA) to starter diets has favorable effects on ruminal development but may reduce starter intake and growth. The latter reductions may be related to an inability of the insufficiently developed ruminal microbiota to effectively use forage. Based on the crucial role of phosphorus (P) for ruminal microbial activity and the overall insufficient knowledge on the interaction of dietary fiber and P in young calves, this study hypothesized that limited availability of dietary P may contribute to the reduced intake and performance in forage-supplemented calves.

Different Derivatives of Plumbagin Analogue: Bioavailability and Their Toxicity Studies.

The roots of the genus, specifically and related species, contain natural plumbagin. Because of its possible medicinal benefits, naphthoquinone has been the subject of several studies. Ongoing research aims to better understand the mechanisms underlying the actions of plumbagin, optimize its distribution and formulation, assess its efficacy and safety in clinical trials.

Preparation of antibacterial and biocompatible dressing by solid phase dispersion matrix and maceration methods based on lawsone extracted from lawsonia inermis.

This study focused on extracting and preconcentrating lawsone (2-hydroxy-1,4-naphthoquinone) from Lawsonia inermis leaves to develop an advanced antibacterial polymer wound dressing designed to prevent infections and enhance wound healing. Utilizing biocompatible cellulose acetate as the base polymer, the material was combined with Ag-MOF (silver-metal-organic frameworks) to serve as a nano-carrier for the controlled release of lawsone. Extraction was performed via maceration and QuEChERS methods, with HPLC and UV-Vis spectrophotometry confirming a significantly higher lawsone yield from QuEChERS (57.

Predicting cancer mortality using machine learning methods: a global vs. Iran analysis.

Background: Cancer remains a leading cause of morbidity and mortality worldwide, with significant variations in incidence, mortality, and survival rates across regions. This study leverages Machine Learning (ML) to analyze global and Iran-specific cancer data, aiming to improve predictive accuracy for cancer mortality.

Methods: Using datasets from Global Cancer Observatory (GLOBOCAN) and the Iran National Cancer Registry (INCR), we evaluate the performance of ML models, including XGBoost, Random Forest, and Support Vector Machines, in predicting cancer outcomes.