Systemic sclerosis in Egyptian population with emphasis on clinical and nailfold capillaroscopic features.

To describe various demographic, clinical, laboratory, and capillaroscopic features of Egyptian patients with systemic sclerosis (SSc) and to explore the relation between various capillaroscopic features and internal organ involvement as well as other disease parameters. In this cross-sectional multi-centric prospective analysis, two hundred twenty-two adult patients with SSc were recruited. Data regarding general and rheumatological examination including the modified Rodnan skin score (MRSS), internal organ involvement and related imaging and laboratory investigations were collected.

Protective and therapeutic potentials of Trichinella spiralis larval antigen in murine induced colitis.

The intolerable side effects and clinical limitations of current conventional therapies for inflammatory bowel diseases (IBDs), there is a pressing need for alternative treatment options. Helminthes adapt immune responses of their hosts to reduce immune-mediated IBDs. The identification of the mechanism responsible for this beneficial effect on IBDs will provide another feasible approach to treating these diseases.

Predicting cancer risk using machine learning on lifestyle and genetic data.

Cancer remains one of the leading causes of mortality worldwide, where early detection significantly improves patient outcomes and reduces treatment burden. This study investigates the application of Machine Learning (ML) techniques to predict cancer risk based on a combination of genetic and lifestyle factors. A structured dataset of 1,200 patient records was used, comprising features such as age, gender, Body Mass Index (BMI), smoking status, alcohol intake, physical activity, genetic risk level, and personal history of cancer.

Understanding the role of medicalisation in mothers' decision-making on daughters' female genital cutting in Assiut, Egypt.

In recent decades, female genital cutting (FGC) has become increasingly medicalised (with the practice being performed by health professionals) in Egypt. Whilst various national and international policies condemn medicalised FGC, the basis for these policies frequently rests on moral arguments and presumed outcomes rather than rigorously derived evidence. What remains largely unaddressed in debate on the shift towards medicalisation of FGC is an understanding of the decision to medicalise, viewed through the lens of the practising communities involved.

The Association of Diabetes Mellitus with Uveitis: A Real-World Data Analysis.

Purpose: To evaluate the association between type 2 diabetes mellitus (T2DM) and type 1 diabetes mellitus (T1DM) with the incidence of uveitis.

Methods: This was a retrospective cohort study utilizing the TriNetX Global Collaborative Network. Anonymized participants were patients diagnosed with T2DM or T1DM, including both insulin users and non-insulin users among those with T2DM, with and without diabetic retinopathy (DR).

Changes in non-culprit coronary lesions with PCSK9 inhibitors: the randomised, placebo-controlled FITTER trial.

Background: Prolonged lipid-lowering therapy has demonstrated its ability to induce plaque regression and improve the plaque morphology of mild atherosclerotic lesions.

Aims: This trial aimed to assess the short-term effect of evolocumab in addition to high-intensity statin therapy (HIST) on relevant non-culprit coronary artery lesions using fractional flow reserve (FFR) measurements and multimodality intracoronary imaging.

Methods: Patients with an acute coronary syndrome (ACS) and relevant multivessel disease were randomised to receive either evolocumab or placebo for 12 weeks in addition to HIST.

Outcomes of empagliflozin in nondiabetic fatty liver patients: A randomized controlled trial.

Objectives: Metabolic fatty liver disease is a common disease with numerous health risks. Life modification remains the primary treatment. Previous studies have shown that the sodium‒glucose cotransporter has a positive effect on improving fatty liver in individuals with diabetes mellitus, but it has not been extensively studied in nondiabetic patients with fatty liver.

CDK2 inhibitors: rationally directed discovery of a novel potent lead derived from cyclohepta[]thieno[2,3-]pyridine.

CDK2 has emerged as a pivotal target in cancer chemotherapy. To develop a novel CDK2 inhibitor scaffold, multiple rational, structure-based design strategies were applied to known potent CDK2 inhibitors. Through retrosynthetic planning, chemical synthesis, and characterisation, compounds 2-8 were generated.

The presence of exotoxin genes and biofilm production in carbapenem-resistant clinical isolates.

Introduction: produces many exotoxins which are essential for the bacterial pathogenesis. The aim of this study was to identify from clinical specimens, detect the sensitivity pattern, biofilm production, and the frequency of exogenes.

Methods: clinical isolates were identified by conventional and genotypic methods.

Unlocking the Potential of ,,','‑Tetraphenylbenzidine Based on Conjugated Microporous Polymers for Rhodamine B Adsorption: A Synergistic Experimental and Density Functional Theory Perspective.

This study presents the synthesis and construction of two innovative conjugated microporous polymers (CMPs), TPBZ-PyT CMP and TPBZ-TPET CMP, which incorporate pyrene (Py) and tetraphenylethene (TPE) subunits, respectively. These subunits are selected for their complementary properties, with the TPE moiety offering enhanced flexibility compared to the more rigid Py structure. The flexibility of TPE is hypothesized to improve the adsorption performance of the CMPs for removing rhodamine B (RhB) dye from aqueous solutions.

MDSC depletion during immunization with heat-killed increases protection against BCG infection.

Tuberculosis (TB) remains one of the deadliest infectious diseases globally. Although the approved human Bacille-Calmette-Guérin (BCG) vaccines provide limited protection, a vaccine based on (Mtb) has yet to be approved. Our previous findings demonstrated that s.

Unleashing the biological potential of marine algal extracts against Staphylococcus aureus isolated from ready-to-eat beef products.

Staphylococcus aureus is the causative agent of zoonotic diseases that are of increasing epidemiological importance and have significant implications for public health. One hundred fifty ready-to-eat meat product samples were collected from local shops in Qena City, Egypt, to investigate the bacteriological profile of S. aureus and evaluate the antimicrobial effects of marine algal extracts against identified S.

Ratiomeric Luminescent Monitoring of Cardiovascular Agents Exploiting Phosphorus and Nitrogen Co-Doped Carbon Quantum Dots as Nano-Sensors: Bioavailability Study in Rabbit Males.

Phosphorus and nitrogen co-doped carbon quantum dots (PNCQDs) were utilized as facile fluorescent probes for accurate monitoring of naftidrofuryl oxalate (NAFT) and rivaroxaban (RIVA). These luminescent templates have shown two emission ratiomeric bands at 335 and 444 nm upon excitation at 273 nm. Successive titration of the carbon dots with NAFT solution showed enhanced fluorescence at 335 nm band, leaving the other band unchanged, while by consecutive addition of RIVA increments to the PNCQDs-NAFT complex, a fluorescence quenching occurred only to the same band.

Transplanted mesenchymal stem cells isolated from the bone marrow ameliorate the histological alterations in the parotid glands of hypothyroid male rats.

Objective: To elucidate the possible outcome of mesenchymal stem cells extracted from the bone marrow (BM-MSCs) on the altered histological structure of the parotid gland of male rats with induced hypothyroidism.

Design: 24 adult male Wistar rats were used. The rats were divided into 3 groups, each containing 8 animals.

Exploring barriers and facilitators to immediate postpartum intrauterine device uptake within the strengthening Egypt family planning program: a case-control study.

Background: Egypt faces significant economic and healthcare challenges due to overpopulation. The Strengthening Egypt Family Planning Program tackles the rapid population growth by improving access to family planning services. Given Egypt's high cesarean section rates, the program leverages this opportunity to facilitate immediate postpartum IUD (IPPIUD) insertion as a safe and efficient method.

Outcome of enzyme replacement therapy for hematological and visceral manifestations in children with acid sphingomyelinase deficiency: a single center experience in upper Egypt.

Background: Thrombocytopenia is the most common hematologic manifestation of acid sphingomyelinase deficiency (ASMD). The introduction of enzyme replacement therapy (ERT) represents significant progress in the treatment landscape of this disorder. This study presents the largest pediatric case series of ASMD to date, providing valuable insights into the real-world application of ERT in affected children.

Unhealthy Ultra-Processed Food, Diet Quality and Adherence to the Mediterranean Diet in Children and Adolescents: The DELICIOUS Project.

Background: Western dietary patterns worldwide are increasingly dominated by energy-dense, nutrient-deficient industrial foods, often identified as ultra-processed foods (UPFs). Such products may have detrimental health implications, particularly if nutritionally inadequate. This study aimed to examine the intake of unhealthy UPFs among children and adolescents from five Mediterranean countries (Italy, Spain, Portugal, Egypt, and Lebanon) involved in the DELICIOUS project and to assess the association with dietary quality indicators.

Biodegradation of lignocellulosic wastes by thermotolerant cellulolytic actinomycetal consortium isolated from Uhud Mountain, Madinah, Saudi Arabia.

The actinomycetal consortium plays a key role in lignocellulose degradation and offers promising applications in sustainable biomass conversion and biotechnology. A thermotolerant lignocellulolytic actinobacterial consortium, composed of strains A5 (Streptomyces cavourensis strain QT227), C13 (Streptomyces parvus 5-94 gene), and C17 (Streptomyces cavourensis strain SIF3) isolated from an arid region in Madinah, Saudi Arabia, demonstrates significant potential in sustainable biomass conversion and biotechnology. This consortium effectively degrades various cellulosic substrates, including bagasse (SB), corncob (CC), and palm leaves (PL), making it suitable for biorefinery processes.

Ethics and informed consent in clinical trial integrity: An international, multi-stakeholder consensus statement by Cairo Consensus Group.

Recent studies have revealed issues with ethical practice and informed consent in randomized clinical trials (RCTs). We aimed to develop an international, multi-stakeholder consensus statement on human research ethics committee approval and informed participant consent for RCTs. The consensus process encompassed a systematic scoping review, modified two-round Delphi survey, and final consensus meeting of a multi-stakeholder group, including trialists, ethics committee members, methodologists, patient representatives, journal editors, and other experts on RCTs.

Gender-specific insights into adherence to Mediterranean diet and lifestyle: analysis of 4,000 responses from the MEDIET4ALL project.

Background: The Mediterranean Diet (MedDiet) is widely recognized for its health benefits, though adherence varies across populations and is influenced by multiple lifestyle and demographic factors. This study examined MedDiet adherence patterns and their associations with lifestyle behaviors, with particular attention to gender differences in a large, multinational cohort.

Methods: Data were obtained via the MEDIET4ALL survey, an international cross-sectional study that included 4,010 participants (mean age: 36.

Incubation time effect on releasing available phosphorus in saline sandy soil as a function of bone char application.

To face the current crisis in global fertilizer prices, especially in developing countries where their food security has been greatly affected, alternative sources must be found for phosphate fertilizers, whose main source is phosphate rock, which is non-renewable and subject to depletion. Therefore, this study aims to evaluate the effect of the incubation period on the availability and fractionation of phosphorus in saline sandy soil under bone char addition. About 100 g of soil was placed in an airtight plastic jar and mixed thoroughly by adding 0.

Optimizing surveillance in Lynch syndrome: lesion detection and comparative performance of different colonoscopy modalities-a systematic review and network meta-analysis.

Purpose: Lynch syndrome patients are at a high risk for developing colorectal cancer; thus, optimal surveillance strategies are required. Although colonoscopic imaging methods differ in diagnostic performance, direct comparisons in this population are not very common. We aimed to evaluate and compare the detection capabilities of white-light endoscopy (WLE), chromoendoscopy, virtual chromoendoscopy (NBI: narrow band imaging, LCI: linked color imaging, I-SCAN), and AI-assisted colonoscopy in detecting neoplastic and non-neoplastic lesions in individuals diagnosed with Lynch syndrome.

International patterns in lipid management and implications for patients with coronary heart disease: results from the INTERASPIRE study.

Aims: To quantify international variations in lipid-lowering therapies (LLT) use among patients with coronary heart disease (CHD) and attainment of European guideline-recommended lipid goals.

Methods And Results: INTERASPIRE is an observational study (2020-23) covering 14 countries from all WHO regions. Patients (18-79 years) hospitalized in the preceding 6-36 months with CHD were invited for standardized interviews and examination, with central laboratory analyses for low-density lipoprotein cholesterol (LDL-C), non-HDL-C, and apolipoprotein B (apoB).