Harnessing for Sustainable Development: Biotechnological and Industrial Relevance.

Fungi, especially Aspergillus species, could have a significant role in tackling challenges of global sustainability because of their diverse industrial and biotechnological applications. The current work aims to explore the biotechnological and industrial potential of Aspergillus fumigatus in achieving sustainable development goals. This fungus has the capability to secrete valuable industrial enzymes, including cellulases, lipases, and proteases, promoting eco-friendly substitutes for chemical processes in different fields such as food, textiles, biofuels, and detergents.

Could Wound Instillation Provide an Efficient Analgesia Comparable to That Provided by PECS-II Block for Modified Radical Mastectomy Using Ketamine-Bupivacaine Combination? A Pilot Study.

Background And Aim: In the light of the abundance of various analgesic methods available for analgesia following modified radical mastectomy (MRM) (pharmacological or interventional), we aimed to try a very simple technique using a drug combination (ketamine-bupivacaine) through wound instillation and to compare it to the reputable PECS-II block using the same drug combination. We hypothesized that, with this drug combination, local instillation may achieve a comparable, long lasting, analgesia for almost 48 hours, with less costly, and simple method.

Patients And Methods: Sixty women scheduled to undergo MRM participated in this study.

Potential of tadalafil and tadalafil-cellulose nanocomposite in preventing postsurgical abdominal adhesions in a rat cecal abrasion model.

The formation of postoperative intra-abdominal adhesions is a significant challenge in veterinary practice worldwide. Thus, several attempts have been made to identify agents that prevent the occurrence of these postsurgical adhesions. However, finding an ideal and effective agent remains a challenge.

The Rocket Incision in Neuromuscular Scoliosis: A Modified Posterior Approach for Enhanced Pelvic Correction and Wound Safety (Retrospective Cohort Study).

Study designRetrospective cohort study.ObjectivesWound complications and suboptimal pelvic correction remain significant challenges in posterior spinal fusion to the pelvis for neuromuscular scoliosis. We describe and evaluate the , a novel modification of the posterior midline approach designed to redistribute closure tension and enhance access for soft tissue release.

Lomitapide, a Microsomal Triglyceride Transfer Protein Inhibitor, in Homozygous Familial Hypercholesterolemia: A Systematic Review and Meta-Analysis of Efficacy and Safety.

Purpose: Homozygous Familial Hypercholesterolemia (HoFH) is a rare and life-threatening genetic disorder characterized by elevated low-density lipoprotein cholesterol (LDL-C) and early-onset atherosclerotic cardiovascular disease. Lomitapide, a microsomal triglyceride transfer protein (MTP) inhibitor, decreases LDL-C independent of LDL receptor function, providing an alternative treatment in this population. We aimed to evaluate the efficacy and safety of lomitapide in patients with HoFH through a systematic review and meta-analysis of available clinical evidence.

Effects of Gabapentin, Valsartan, and Codeine on hemato-biochemical and histological biomarkers of male catfish (Clarias gariepinus).

Pharmaceutical residues in aquatic environments are emerging contaminants of concern due to their potential sublethal and chronic impacts on aquatic organisms. This study aimed to evaluate the subacute toxicological effects of three widely used pharmaceuticals-gabapentin (GAB), valsartan (VAL), and codeine (COD)-on male African catfish (Clarias gariepinus). Fish were randomly assigned to four groups: a control group and three treatment groups exposed for 15 days to environmentally relevant concentrations of GAB (79.

Risk Genes and Anti-C1q Autoantibodies in Upper Egyptian Patients With Systemic Lupus Erythromatosis-High Frequency of HLA-DRB1*04:05-DQA1*03-DQB1*02 Risk Haplotype in Lupus Nephritis Patients.

This study was performed to determine anti-C1q serum level, genetic polymorphism in cytotoxic T lymphocyte-associated antigen 4 gene (CTLA-4 gene) (rs 231775), and HLA class II genes in susceptibility and early prediction of systemic lupus erythematosus (SLE) and lupus nephritis (LN) in Upper Egyptian patients. A total of 60 unrelated cases of SLE (30 cases with LN) and 60 healthy controls were studied for HLA-DQB1, HLA-DQA1, and HLA-DRB1 (DR4 subtypes) alleles. Anti-C1q level was estimated by ELISA.

Redox-innocent scandium(III) as the sole catalyst in visible light photooxidations.

In recent years, the catalytic activity of scandium triflate Sc(OTf) has attracted significant attention due to its robust Lewis acidity and the oxophilicity of Sc. These features have led to impressive progress in developing diverse organic reactions, including C-C bond formation. The Sc also facilitates single electron transfer in photoinduced reactions either by coordination to an organophotoredox catalyst, which modifies its redox reactivity, or by the formation of a scandium-superoxide anion complex after electron transfer from a light-absorbing redox-active compound.

Survival Patterns and Mortality Causes in Patients with Invasive Ependymoma: A Retrospective Cohort Analysis from 2000 to 2019.

Background: Ependymomas are primary CNS neoplasms that arise from the ependymal cells of the brain and spinal cord, accounting for 3-6% of all CNS tumors.

Aims: This study provides a comprehensive analysis of ependymoma survival patterns and examines non-cancer causes of death in the US.

Methods: This retrospective study used data from SEER 17 registries between 2000 and 2019 to evaluate the incidence of ependymoma, as well as the survival and mortality trends in the US.

Sleep Disorders and Stroke: Pathophysiological Links, Clinical Implications, and Management Strategies.

Sleep disorders and stroke are intricately linked through a complex, bidirectional relationship. Sleep disturbances such as obstructive sleep apnea (OSA), insomnia, and restless legs syndrome (RLS) not only increase the risk of stroke but also frequently emerge as consequences of cerebrovascular events. OSA, in particular, is associated with a two- to three-fold increased risk of incident stroke, primarily through mechanisms involving intermittent hypoxia, systemic inflammation, endothelial dysfunction, and autonomic dysregulation.

National Eye Institute Supported Randomized Controlled Trials in Keratoplasty for Endothelial Disorders: Lessons Learned.

National Eye Institute (NEI)-funded randomized controlled trials (RCTs) have significantly shaped the modern landscape of keratoplasty for endothelial disorders. Unlike retrospective studies, RCTs have offered the highest level of clinical evidence and have addressed critical questions related to histocompatibility matching, donor and donor tissue characteristics, donor tissue storage, and operative and postoperative factors supporting postoperative endothelial cell health. These RCTs have in turn directly influenced eye banking and keratoplasty practices.

Treatment recommendations for the systemic pharmacological treatment of systemic sclerosis digital ulcers: Results from the World Scleroderma Foundation Ad Hoc Committee.

Introduction: Digital ulcers are an important disease manifestation of systemic sclerosis and are associated with significant morbidity. As such, there is an urgent need for the development of evidence-based recommendations to guide clinicians in the treatment of digital ulcers.

Methods: A steering committee of international experts was established.

Triptorelin 0.1 mg as a Luteal Phase Support in Antagonist Intracytoplasmic Sperm Injection Cycles.

Background: Transvaginal progesterone is used to aid throughout the luteal phase. Administering a dose of gonadotrophin-releasing-hormone analogues (GnRHa) six days following OPU in GnRH antagonist cycles might cause rise in pituitary gonadotropins (luteinizing hormone (LH) and follicle-stimulating hormone (FSH)), leading to rise in steroid synthesis (estradiol (E2) and progesterone (P)) by the corpora lutea (CL). This work aimed to contrast the effect of lipopolysaccharides (LPS) with adding GnRHa to progesterone P, at day six after ovum pickup versus P alone, on the clinical pregnancy rate.

Chitosan-Nanoparticles Mitigate Cadmium Chloride Hepatorenal Toxicity in BALB/C Mice Via Amendment of Nrf2/HO-1 and NF-κB/iNOS Signaling Pathways.

The current aim was to evaluate the protective effects of chitosan nanoparticles against cadmium chloride (CdCl₂)-induced hepatic and renal toxicity and to elucidate the underlying mechanisms with a focus on the modulation of oxidative stress, inflammation, and apoptosis via the Nrf2/HO-1 and NF-κB/iNOS signaling pathways. Four groups were used: group I (control), group II (CS-NPs), group III (CdCl), and group IV (CdCl + CS-NPs). Biochemical, histopathological, and immunohistochemical studies of hepatorenal parameters were performed.

Timing of Outpatient Stenting Is Associated With Stent Size in Non-Thrombotic Iliac Vein Lesions.

Objective: Stent placement is commonly used to treat non-thrombotic iliac vein lesions. On the day of surgery, patients typically fast after midnight and may often present with volume deficits and various degrees of dehydration. This study aims to determine if the time of day a venogram is performed predicts the size of the iliac vein stent used to treat non-thrombotic iliac vein lesions.

Interactive effects of black sand and heat stress on coral reefs at Red Sea, Egypt.

Coral reefs, vital marine ecosystems, face increasing threats from climate change and localized stressors like black sand deposits, yet their combined impacts are underexplored. This pioneering study investigates the synergistic effects of rising temperatures and black sand on reef-building corals in the Red Sea, Egypt, focusing on Stylophora pistillata and Acropora hyacinthus. Coral samples were collected from Hurghada and exposed to a three-day laboratory experiment involving thermal stress (31 °C), black sand (300 mg/L), nano black sand (300 mg/L), and combinations thereof.

Impact of oral nicorandil administration prior to primary percutaneous coronary intervention on no-reflow: a randomized controlled trial.

Background: Prior studies and meta-analyses showed cardioprotective benefits of intravenous or intracoronary nicorandil administration in ST-segment elevation myocardial infarction (STEMI). However, little is known about the efficacy of oral nicorandil in this context, especially that parenteral forms are not widely available.

Aim: To investigate the impact of oral nicorandil administered before primary percutaneous coronary intervention (PPCI) on no-reflow and to assess the in-hospital and 3-month major adverse cardiac events (MACE).

Artificial Intelligence Applications in Healthcare: A Systematic Review of Their Impact on Nursing Practice and Patient Outcomes.

Background: Artificial Intelligence is revolutionizing healthcare by addressing complex challenges and enhancing patient care. AI technologies, such as machine learning, natural language processing, and predictive analytics, offer significant potential to impact nursing practice and patient outcomes.

Aims: This systematic review aims to assess the impact of Artificial Intelligence applications in healthcare on nursing practice and patient outcomes.

A scalable machine learning strategy for resource allocation in database.

Modern cloud computing systems require intelligent resource allocation strategies that balance quality-of-service (QoS), operational costs, and energy sustainability. Existing deep Q-learning (DQN) methods suffer from sample inefficiency, centralization bottlenecks, and reactive decision-making during workload spikes. Transformer-based forecasting models such as Temporal Fusion Transformer (TFT) offer improved accuracy but introduce computational overhead, limiting real-time deployment.

Nanoparticles boost pomegranate growth and defense, suppressing root-knot nematodes.

Root-knot nematodes ( spp.) are a major threat to pomegranate cultivation. Nanoparticles (NPs) present a possible substitute nematicide that lessens dependency on potentially dangerous chemical nematicides.

Biallelic variants in COX18 cause a mitochondrial disorder primarily manifesting as peripheral neuropathy.

Defects in mitochondrial dynamics are a common cause of Charcot-Marie-Tooth disease (CMT), while primary deficiencies in the mitochondrial respiratory chain (MRC) are rare and atypical for this etiology. This study aims to report COX18 as a novel CMT-causing gene. This gene encodes an assembly factor of mitochondrial Complex IV (CIV) that translocates the C-terminal tail of MTCO2 across the mitochondrial inner membrane.

Systemic sclerosis in Egyptian population with emphasis on clinical and nailfold capillaroscopic features.

To describe various demographic, clinical, laboratory, and capillaroscopic features of Egyptian patients with systemic sclerosis (SSc) and to explore the relation between various capillaroscopic features and internal organ involvement as well as other disease parameters. In this cross-sectional multi-centric prospective analysis, two hundred twenty-two adult patients with SSc were recruited. Data regarding general and rheumatological examination including the modified Rodnan skin score (MRSS), internal organ involvement and related imaging and laboratory investigations were collected.

Protective and therapeutic potentials of Trichinella spiralis larval antigen in murine induced colitis.

The intolerable side effects and clinical limitations of current conventional therapies for inflammatory bowel diseases (IBDs), there is a pressing need for alternative treatment options. Helminthes adapt immune responses of their hosts to reduce immune-mediated IBDs. The identification of the mechanism responsible for this beneficial effect on IBDs will provide another feasible approach to treating these diseases.