Esthetic Rehabilitation of Bilaterally Missing Maxillary Lateral Incisors in a Young Adult: A Step-by-Step Clinical Case Report.

This case report shows the esthetic rehabilitation of a young female patient with congenitally missing maxillary lateral incisors, a fractured previous fixed prosthesis, and dissatisfaction with her smile. A minimally invasive approach was followed, utilizing digital smile design with ExoCAD (Exocad GmbH, Darmstadt, Germany) digital software to plan and fabricate zirconia bridges following minimal crown preparation. The treatment aimed to restore both function and esthetics, resulting in a natural-looking, harmonious smile.

Different Zirconia Surface Treatments: Strategies to Enhance Adhesion in Zirconia-Based Dental Restorations.

All-ceramics have been widely used in dentistry. The favorable mechanical properties and high biocompatibility of zirconia ceramics lead to using it as an alternative to the conventional porcelain-fused-to-metal (PFM) restorations. However, its major limitation is the difficulty of achieving proper bonding due to the chemical inertness of its surface.

Cytotoxic Metabolites from Pericarp of .

Background: The pericarp of (mangosteen) has been used as a medicinal agent by Southeast Asians for centuries in the treatment of skin infections and wounds. Its main active constituents were xanthones and phenolic compounds. The plant and its metabolites possessed diverse bioactivities.

Harnessing for Sustainable Development: Biotechnological and Industrial Relevance.

Fungi, especially Aspergillus species, could have a significant role in tackling challenges of global sustainability because of their diverse industrial and biotechnological applications. The current work aims to explore the biotechnological and industrial potential of Aspergillus fumigatus in achieving sustainable development goals. This fungus has the capability to secrete valuable industrial enzymes, including cellulases, lipases, and proteases, promoting eco-friendly substitutes for chemical processes in different fields such as food, textiles, biofuels, and detergents.

Molecular Docking, Molecular Dynamics Simulation, and Pharmacophore-Based Virtual Screening Unveil Natural Compounds with TIM-3 Inhibitory Activity.

Introduction: The aberrant expression of T cell immunoglobulin mucin-3 (TIM-3) has been linked to adaptive immunotherapy resistance and poor prognosis. Targeting TIM-3 has gained popularity due to positive outcomes in preclinical settings.

Materials And Method: This research explored the Supernatural 3.

Screening Enamine Fragments Library in the Quest for Novel SOS2 Inhibitors: Pharmacophore Modelling, Molecular Docking, MMGBSA Calculations, and MD Simulation.

Introduction: The son of sevenless (SOS) proteins are rat sarcoma virus nucleotide exchange factors that act as regulatory switches of the rat sarcoma virus (RAS) system through the conversion of the inactive guanosine diphosphate (GDP) bound RAS to the GTP-bound active form, thereby modulating numerous biological events. SOSs contribute in disease incidence and progression in numerous cancers. Currently, SOSs inhibiting strategies deemed a substantial interest in the fight against cancer.

Exploring Novel Y140F/H Mutant Fungal CYP51 Inhibitors: A Molecular Docking and Dynamics Study on Thiophene Compounds.

Background: Invasive fungal infections (IFIs) pose a significant risk specifically to the health of immunocompromised individuals, leading to a substantial number of deaths annually. Therapeutic options for IFIs are limited compared to bacterial infections, with only three classes of antifungal medications currently in use. The widespread use of triazole antifungals for IFI prevention and treatment, along with long treatment durations, has led to the emergence of severe drug resistance, indicating the urgent need for intervention to address this critical issue.

Natural Hydrazone Derivatives: Their Sources, Structures, and Bioactivities.

Hydrazone-containing compounds are a diverse group of bioactive compounds known for their unique chemical features and diverse biological activities. Natural hydrazone derivatives have been identified from various natural sources, including bacteria, plants, fungi, and marine organisms. This work provides a comprehensive review of published works on natural hydrazone derivatives, including their sources, structural features, and biological activity in the period from 1967 to March 2025.

from Pathogenic Fungus to Unexplored Natural Treasure: Changing the Concept.

The genus is one of the oldest known fungal genera. Its species can survive in extremely difficult environmental conditions and can affect plants, animals, and human health due to their pathogenic characteristics. Also, they represent an enormous chemical and biological repertoire.

Urolithin B as a renoprotective agent against 5-fluorouracil-induced nephrotoxicity: Role of Nrf2/Keap1/HO-1, SIRT1/FOXO3, and NF-кB/TNF-α signaling pathways.

The clinical use of 5-fluorouracil (5-FU) in cancer patients has been associated with nephrotoxicity, which is greatly curbing its therapeutic application. The pathogenesis of 5-FU-induced nephrotoxicity is complex; however, oxidative stress-mediated inflammation is considered a central pathogenic factor. Urolithin B (UB), a product of ellagitannins, has recently been assigned diverse pharmacological activities due to its potent antioxidant and anti-inflammatory properties.

Paraherquamides - A new hope and great expectations of anthelmintic agents: Computational studies.

Nematode infections impose a significant health and economic burden, particularly as parasites develop resistance to existing treatments and evade host defenses. This study explores the efficacy of 48 paraherquamide analogs, a class of polycyclic spiro-oxindole alkaloids with unique structural features, as potential anthelmintic agents. Employing advanced computational methods, including molecular docking, MM-GBSA, and molecular dynamics simulations, we assessed the interaction of these analogs with the Ls-AchBP receptor, a model for nematode neurotransmission.

Prenylated xanthones from mangosteen (Garcinia mangostana) target oxidative mitochondrial respiration in cancer cells.

Mangosteen (Garcinia mangostana) is well-known for its nutritional value and health benefits. Breast cancer is the most common cancer and the leading cause of cancer-related mortality among females worldwide. Here we show that the prenylated xanthones, α-mangostin, γ-mangostin, 9-hydroxycalabaxanthone (9-HCX), and garcinone E from the mangosteen pericarp exhibit cytotoxicity against a panel of human cancer cell lines including lung adenocarcinoma (A549), cervical carcinoma (HeLa), prostatic carcinoma (DU 145), pancreatic carcinoma (MIA PaCa-2), hepatocellular carcinoma (Hep G2), bladder urothelial cancer (5637), as well as the triple-negative breast cancer cells MDA-MB-231.

Unveiling the potential of phytochemicals to inhibit nuclear receptor binding SET domain protein 2 for cancer: Pharmacophore screening, molecular docking, ADME properties, and molecular dynamics simulation investigations.

Nuclear receptor binding SET domain protein 2 (NSD2) significantly contributes to the development of cancer, making it a promising target for cancer drug discovery. This research explores natural compounds as potential selective inhibitors for NSD2 in cancer treatment. Employing a comprehensive in silico approach, the study utilized pharmacophore modeling, molecular docking, pharmacokinetic profiling, and molecular dynamics simulations.

Arctigenin from Burdock Root Exhibits Potent Antibacterial and Anti-Virulence Properties against .

(Burdock) root is used in various culinary applications especially in Asian Cuisine. Arctigenin (ARC) is a polyphenolic compound abundant in the roots of the burdock plant from which it derives its name. The emergence of bacterial resistance is a growing global worry, specifically due to the declining availability of new antibiotics.

Targeting SIRT1/AMPK/Nrf2/NF-кB by sitagliptin protects against oxidative stress-mediated ER stress and inflammation during ANIT-induced cholestatic liver injury.

Intrahepatic cholestasis is a common clinical form of hepatobiliary injury characterized by the intrahepatic accumulation of toxic bile acids. Besides its antidiabetic activity, the dipeptidyl peptidase IV inhibitor sitagliptin (SG) has been recently assigned diverse pharmacological activities and therapeutic potential against different disorders owing to its emerging antioxidant and anti-inflammatory properties. The current study explored the potential hepatoprotective effect of SG on α-naphthyl isothiocyanate (ANIT)-induced cholestatic liver injury (CLI) in mice and investigate its possible targeted signaling pathways.

α-Glucosidase, butyrylcholinesterase and acetylcholinesterase inhibitory activities of phenolic compounds from L. flowers: and studies.

Chemical investigation of L. flowers resulted in isolation of seven metabolites that were identified as; -Hydroxybenzoic acid (), hydroxy cinnamic acid (), kaempferol-6-C-glucoside (), astragalin (), cartormin (), kaempferol-3--rutinoside (), and kaempferol-3--sophoroside (). Virtual screening of the isolated compounds against human intestinal α-glucosidase, acetylcholinesterase, and butyrylcholinesterase was carried out.

Kaempferol sophoroside glucoside mitigates acetaminophen-induced hepatotoxicity: Role of Nrf2/NF-κB and JNK/ASK-1 signaling pathways.

APAP (Acetaminophen)-induced hepatic injury is a major public health threat that requires continuous searching for new effective therapeutics. KSG (Kaempferol-3-sophoroside-7-glucoside) is a kaempferol derivative that was separated from plant species belonging to different genera. This study explored the protective effects of KSG on ALI (acute liver injury) caused by APAP overdose in mice and elucidated its possible mechanisms.

Piceatannol: a renaissance in antibacterial innovation unveiling synergistic potency and virulence disruption against serious pathogens.

In the relentless battle against multi-drug resistant Gram-negative bacteria, piceatannol emerges as a beacon of hope, showcasing unparalleled antibacterial efficacy and a unique ability to disrupt virulence factors. Our study illuminates the multifaceted prowess of piceatannol against prominent pathogens-Proteus mirabilis, Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae. Notably, piceatannol demonstrated a remarkable ability to inhibit biofilm formation, reduce bacterial mobility, and diminish extracellular enzyme synthesis.

Protective effect of kaempferol glucoside against lipopolysaccharide-caused acute lung injury via targeting Nrf2/NF-κB/NLRP3/GSDMD: Integrating experimental and computational studies.

The current study explored the protective potential of kaempferol 3-sophoroside-7-glucoside (KSG) against acute lung injury (ALI). Pre-treatment with KSG effectively secured mice from ALI and showed similar efficaciousness to dexamethasone. KSG markedly increased the survival rate and alleviated lung pathological lesions induced by lipopolysaccharide (LPS).

Exploring the potential of Aspergillus wentii: secondary metabolites and biological properties.

Fungi are of considerable importance due to their capacity to biosynthesize various secondary metabolites with bioactive properties that draw high attention in new drug discovery with beneficial uses for improving human well-being and life quality. Aspergillus genus members are widespread and cosmopolitan species with varying economic significance in the fields of industry, medicine, and agriculture. Its species are renowned for their biosynthesis of secondary metabolites, characterized by both potent biological activity and structural novelty, making them a substantial reservoir for the development of new pharmaceuticals.

Modulation of the crosstalk between Keap1/Nrf2/HO-1 and NF-κB signaling pathways by Tomatidine protects against inflammation/oxidative stress-driven fulminant hepatic failure in mice.

Fulminant hepatic failure (FHF) is the terminal phase of acute liver injury, which is characterized by massive hepatocyte necrosis and rapid hepatic dysfunction in patients without preexisting liver disease. There are currently no therapeutic options for such a life-threatening hepatic failure except liver transplantation; therefore, the terminal phase of the underlying acute liver injury should be avoided. Tomatidine (TOM), asteroidal alkaloid, may have different biological activities, including antioxidant and anti-inflammatory effects.

RETRACTED: Alhakamy et al. Fluoxetine Ecofriendly Nanoemulsion Enhances Wound Healing in Diabetic Rats: In Vivo Efficacy Assessment. 2022, , 1133.

The journal retracts the article, "Fluoxetine Ecofriendly Nanoemulsion Enhances Wound Healing in Diabetic Rats: In Vivo Efficacy Assessment" [...