A New Technique for Mechanical Thrombectomy in Patients With Acute Pulmonary Embolism: A Case Series.

Acute PE is a serious illness that has a high mortality. Systemic anticoagulation, systemic thrombolysis, catheter-directed thrombolysis, and mechanical thrombectomy are the four main types of therapies used today for PE. The innovative "smart" catheter tubing system of the Penumbra Indigo System (Penumbra Inc.

CNN-LSTM-AM approach for outdoor wireless optical communication systems.

This paper introduces the enhancement of Visible Light Communications (VLC) for V2V using artificial intelligence models. Different V2V scenarios are simulated. The first scenario considers a specific longitudinal separation and a variable lateral shift between vehicles.

Protective efficacy of nanoencapsulation of algal extract for preventing and controlling Clostridium botulinum in fish products.

Research is being conducted on the usage of algae extracts as natural preservatives in the storage of fish products to extend shelf life, maintain quality and safety, and satisfy consumer preferences. Laurencia obtusa (Hudson), Actinotrichia fragilis (Forsskål) Børgesen, and Gracilaria dendroids sp. nov.

Telehealth and challenges of statin adherence in patients with diabetes: a randomized controlled trial.

Background: The success of any therapeutic regimen can be achieved only if patients adhere to the prescribed regimen. Finding an effective intervention to improve patient adherence is challenging.

Aim: To evaluate the effect of telehealth through short messaging services (SMSs) on adherence to statins in patients with diabetes.

The Critical Role of the C-terminal Lobe of Calmodulin in Activating Eukaryotic Elongation Factor 2 Kinase.

Eukaryotic elongation factor-2 kinase (eEF-2K), a member of the α-kinase family, modulates translational rates by phosphorylating eEF-2, a GTPase that facilitates the translocation of the nascent chain on the ribosome during the elongation phase of protein synthesis. eEF-2K is regulated by diverse cellular cues, many of which sensitize it to the Ca-effector protein calmodulin (CaM). CaM, which binds and allosterically activates eEF-2K in the presence of Ca, contains two structural "lobes," each with a pair of Ca-binding EF-hands.

Modified serrated-tip cannulated screwdriver as a sleeve for anterior column screw insertion in percutaneous acetabular fixation: A technical note and a report of two cases.

Percutaneous fixation of certain types of acetabular fractures is a valid, minimally invasive, and successful procedure. However, the technique for proper insertion of such screws is sensitive and requires adequate understanding of radiographic images. Furthermore, an optimum entry point and trajectory of the screws should be guaranteed to avoid hip joint penetration and screws misplacement.

The World Stroke Organization Future Leaders Programme: Building Leadership Capacity in Global Stroke Care.

Background: Leadership development is essential to advancing stroke care globally. The World Stroke Organisation (WSO) Future Stroke Leaders Programme (FSLP) was established to identify and support global early-career professionals in stroke care worldwide. The program offers structured leadership training, mentorship, and seed funding for implementation projects.

Changing profile and burden of hepatocellular carcinoma in Arab Countries in 1990-2021.

Introduction And Objectives: Hepatocellular carcinoma (HCC) remains a major health burden in Arab countries, with notable shifts in etiology and epidemiology over recent decades. This study evaluates the changing burden and profile of HCC across 22 Arab nations from 1990 to 2021.

Materials And Methods: We analyzed the Global Burden of Disease (GBD) 2021 data for 22 Arab countries, extracting age-standardized rates (ASR) and estimated annual percentage changes (EAPC) for HCC incidence, prevalence, mortality, and disability-adjusted life years (DALYs), stratified by etiology and gender.

Fluoroquinolones as Versatile Scaffolds: Potential for Targeting Classical and Novel Mechanisms to Combat Antibacterial Resistance.

Antibiotics play an essential role in combating infectious diseases. Due to the emergence of multidrug-resistant bacteria, the efficacy of antibiotic therapy is continually decreasing. Consequently, there is an urgent need for the development of novel antibiotics, preferably with novel targets that have not yet been clinically exploited and/or multiple mechanisms of action, reducing the probability of fast resistance development.

The Effect of Electrode Materials on the Fusion Rate in Multi-State Fusion Reactors.

This study assesses how different anode materials influence neutron production rates (NPRs) in multi-state fusion (MSF) reactors, with a particular focus on the effects of deuterium (D) pre-loading on the anode surface. Three types of mesh anodes were assessed: stainless steel (SS), zirconium (Zr), and D pre-loaded zirconium (ZrD). MSF operates using two electrodes to confine ions to various fusion reactions, including D-D and D-T.

Impact of Larvae on Nile Tilapia (): A Morpho-Histopathological Perspective.

(Joyeux and Baer, 1935) larvae, a member of the Gryporhynchidae family (Cestoda: ), are commonly found in a variety of African fish species, including Nile tilapia (, Linnaeus, 1758). Nonetheless, little is known regarding their existence in native Egyptian fish species. Two hundred were examined in the current investigation, using standard parasitological techniques to detect the presence of these larvae in different fish organs.

Knowledge, attitudes, and awareness of breast self-examination among female university students in three Arab countries: a multi-center cross-sectional study.

Background: Breast Cancer (BC) is a significant leading cause of death among women. With an estimated 2.1 million new cases annually, it represents the most prevalent malignancy affecting women worldwide.

Cord blood cytokines as early predictors for retinopathy of prematurity.

BackgroundRetinopathy of prematurity (ROP) is a significant cause of childhood blindness. Since ROP typically presents no clinical symptoms or signs in early infancy, timely screening of preterm infants is essential for diagnosis. However, fundus examinations cannot always be performed at the optimal time.

Thoracolumbar Fractures: Historical Systems and Advancements With the AO Spine Classification.

Study DesignSystematic Review.ObjectiveTo describe the historical classifications of thoracolumbar injuries and their evolution into the AO Spine Thoracolumbar Injury Classification System.MethodsA systematic review of MEDLINE, EMBASE and Cochrane Databases was performed in keeping with Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines.

Flavonols as potent inhibitors of tyrosinase & pancreatic lipase: synthesis, docking, MD simulation, DFT, and ADMET.

Aims: Tyrosinase and pancreatic lipase are key enzymes involved in melanin biosynthesis and lipid metabolism, respectively. Their inhibition offers therapeutic potential in treating hyperpigmentation and obesity. This study aimed to synthesize and evaluate a series of flavonols () as potential dual enzyme inhibitors.

Sensitive detection of amantadine in food matrices using DTT-functionalized gold nanoparticles.

Detecting amantadine (AMD) residues in food is essential due to its illegal use in livestock for disease prevention and growth promotion, practices that can lead to harmful drug residues in meat, eggs, and milk. Such residues pose significant public health concerns, including the development of drug-resistant pathogens. In this study, a highly sensitive and selective fluorometric method is presented for detecting AMD in food matrices.

Beneficial Role of Zinc in Metabolic Syndrome: Understanding the Underlying Pathophysiological Mechanisms.

Metabolic syndrome (MetS) is a complex disorder that comprises metabolic abnormalities such as central obesity, insulin resistance, dyslipidemia, and hypertension. Eventually, MetS leads to type 2 diabetes (T2DM) and increases the risk of other cardiovascular diseases. Patients with MetS are approximately five times more prone to develop T2DM.

High Efficacy of Triclabendazole/Ivermectin Combination Compared to Triclabendazole Monotherapy for Treating Human Fascioliasis in Upper Egypt: A Prospective Study.

Triclabendazole (TCBZ) is the gold standard treatment for fascioliasis. However, reports on resistance are increasing, emphasizing the need for alternative therapy. Combining TCBZ with ivermectin (IVM) was found to be effective for treating animal fascioliasis.

Safety and Efficacy of Immune Checkpoint Inhibitors in Human Immunodeficiency Virus-Associated Cancer: A Systematic Scoping Review.

People living with human immunodeficiency virus (PHIV) are at increased risk for malignancies, yet their access to immunotherapy remains limited due to concerns about safety and efficacy. This systematic scoping review evaluates the use of immune checkpoint inhibitors (ICIs) in HIV-associated cancers, analyzing patient outcomes, safety profiles, and the impact on HIV status. A comprehensive literature search was conducted in databases including PubMed, Scopus, Web of Science (WoS), and Medline, up to January 2025.

Development of an AI-powered AR glasses system for real-time first aid guidance in emergency situations.

AI-powered augmented reality (AR) systems provide real-time, hands-free guidance, enabling untrained individuals to respond effectively in emergencies. By combining AI decision-making with AR visuals, they enhance awareness, reduce stress, and help bridge the gap before professional help arrives, especially in critical or underserved settings. This paper introduces an AI-powered augmented reality (AIAR) platform designed to assist untrained bystanders in delivering effective emergency response.

Low-energy room-temperature carbon dots for targeted sensing of MET inhibitor capmatinib.

Capmatinib (CMB) monitoring in biological fluids is critical for evaluating its pharmacokinetics, optimizing dosing, and minimizing toxicity. Accurate measurement is essential for ensuring therapeutic efficacy, enabling personalized treatment, and preventing adverse effects. Given the variability in patient metabolism and excretion, regular monitoring helps maintain CMB levels within the therapeutic range, improving treatment outcomes and minimizing the risk of drug resistance.

Proteomic profiling identifies serpin G1, ApoA-II, and LBP as potential biomarkers of dementia in an Egyptian cohort.

Background: Dementia, including Alzheimer's disease (AD), is a growing concern in Egypt, yet biomarker research in this population is scarce. Identifying serum biomarkers is essential for early diagnosis and understanding disease mechanisms in underrepresented groups.

Methods: We performed serum proteomic profiling on 20 Egyptian dementia patients and 10 cognitively unimpaired controls from the Egyptian Dementia Registry using mass spectrometry.

Hybrid nucleobase-heterocycle-2-oxindole scaffolds as innovative cell cycle modulators with potential anticancer activity.

A series of hybrid molecules 6a-6d-13a-13d combining pyrazolo[3,4-]pyrimidine or aminopurine frameworks with an oxindole moiety were designed as multitarget anticancer agents. Several compounds, especially 8b and 12a-12d, showed potent antiproliferative effects against three human cancer cell lines: A498 (kidney carcinoma), HepG-2 (hepatocellular carcinoma), and MDA-MB-231 (breast adenocarcinoma). Compounds 6b, 7b, 8b, and 12a-12c exhibited remarkable CDK6 inhibition (pIC of up to 7.

Cytotoxic Metabolites from Pericarp of .

Background: The pericarp of (mangosteen) has been used as a medicinal agent by Southeast Asians for centuries in the treatment of skin infections and wounds. Its main active constituents were xanthones and phenolic compounds. The plant and its metabolites possessed diverse bioactivities.