Sensitive detection of amantadine in food matrices using DTT-functionalized gold nanoparticles.

Detecting amantadine (AMD) residues in food is essential due to its illegal use in livestock for disease prevention and growth promotion, practices that can lead to harmful drug residues in meat, eggs, and milk. Such residues pose significant public health concerns, including the development of drug-resistant pathogens. In this study, a highly sensitive and selective fluorometric method is presented for detecting AMD in food matrices.

Low-energy room-temperature carbon dots for targeted sensing of MET inhibitor capmatinib.

Capmatinib (CMB) monitoring in biological fluids is critical for evaluating its pharmacokinetics, optimizing dosing, and minimizing toxicity. Accurate measurement is essential for ensuring therapeutic efficacy, enabling personalized treatment, and preventing adverse effects. Given the variability in patient metabolism and excretion, regular monitoring helps maintain CMB levels within the therapeutic range, improving treatment outcomes and minimizing the risk of drug resistance.

Dithioerythritol-capped silver/gold nanoclusters for determination of ciprofloxacin, norfloxacin, and enrofloxacin in food and urine samples.

Fluoroquinolones (FQs) are widely used in the poultry and livestock industries due to their effectiveness in preventing and treating bacterial infections. However, improper use and poor biodegradability lead to their accumulation in the food chain, posing risks to human health. To address this, a novel ratiometric fluorescence probe was developed for sensitive FQ detection.

Dual modification of nickel nanoclusters for selective detection of glutathione through a competitive displacement mechanism.

Glutathione (GSH) is a vital biomolecule that plays a fundamental role in biological systems, regulating numerous cellular functions. Given its physiological significance, the development of analytical sensors capable of sensitively and selectively detecting GSH is of great importance. In this study, a novel fluorescent probe was designed for the detection of GSH in dietary supplements and human biological fluids.

Uric acid detection dual-mode mechanism with copper-coordinated nitrogen-doped carbon dots as peroxidase mimics.

Monitoring disease-related biomarkers, such as uric acid in human body fluids, is essential for effective disease management and clinical diagnosis. In this study, copper-coordinated nitrogen-doped carbon dots (Cu@N-CDs) were synthesized a simple hydrothermal method, achieving a remarkable photoluminescence quantum yield of 44.69%.

Colorimetric and fluorometric dual-mode determination of hypochlorite based on redox-mediated quenching.

We have successfully created a dual-modal probe, labeled as of iron(ii)-ortho-phenanthroline/N, S@g-CDs, which combines both fluorometric and colorimetric techniques for the accurate and sensitive detection of hypochlorite (ClO). The mechanism behind this probe involves the fluorescence quenching interaction between nitrogen and sulfur co-doped green emissive carbon dots (N, S@g-CDs) and the iron(ii)-ortho-phenanthroline chelate, utilizing both the inner filter effect and redox processes. As the concentration of ClO increases, the iron(ii) undergo oxidation to iron(iii) as follows: Fe(ii) + 2HClO = Fe(iii) + ClO + HO, leading to the restoration of N, S@g-CDs fluorescence.

Facile fabrication of boron and nitrogen co-doped carbon dots for "ON-OFF-ON" fluorescence sensing of Al and F ions in water samples.

Water contamination with harmful ions has grown to be a significant environmental issue on a global scale. Therefore, the fabrication of simple, cost-effective, and reliable sensors is essential for identifying these ions. Herein, co-doping of carbon dots with new caffeine and HBO-derived boron (B) and nitrogen (N) was performed (BN@CDs).