Dorsal Penile Curvature in Children.

Purpose: To review the current literature on dorsal penile curvature (DPC) in children, including its etiology, diagnosis, and principles of treatment.

Materials And Methods: A literature review was conducted on DPC in children, focusing on its etiology (e.g.

A Randomized Trial of Cervical Stabilization Exercise Training Via Telerehabilitation for Migraine.

Purpose: To compare the effects of cervical stabilization exercise training via telerehabilitation (CSET-T) in addition to standard treatment on pain, forward head posture, cervical mobility, muscle performance, functional status, sleep quality, and quality of life in individuals with migraine in comparison to the standard treatment alone.

Methods: The control group (n = 20) received standard treatment alone (medication+recommendations). The stabilization group (n = 20) was given CSET-T in addition to standard treatment 3 days a week for 8 weeks.

Dual-Action Nanotherapy: Temozolomide-Loaded, Anti-PD-L1 scFv-Functionalized Lipid Nanocarriers for Targeted Glioblastoma Therapy.

Glioblastoma (GBM) is a highly malignant brain tumor with limited treatment options and poor prognosis. GBM exhibits resistance to conventional therapies, including temozolomide (TMZ), radiotherapy, and immunotherapy, partly due to immunosuppressive mechanisms such as programmed death-ligand 1 (PD-L1) overexpression. To address these challenges, we developed TMZ-loaded nanostructured lipid carriers (NLCs) conjugated with anti-PD-L1 single-chain variable fragments (scFv) for dual chemo-immunotherapy.

Evaluation of Kienböck's Disease through Distal Radius Sagittal Plane Analysis.

Background: Kienböck's disease poses challenges in plate placement during radial shortening osteotomy due to steep metaphyseal inclinations of the distal radius. While coronal plane analyses have been extensively studied, sagittal plane deformities remain underexplored. This study addresses the anatomical variations in the sagittal plane associated with Kienböck's disease.

The Evidence for Biomechanical and Physiological Parameters as Biomarkers to Discriminate Between Individuals With and Without Non-specific Neck Pain Using Sensor Devices: A Systematic Review with Meta-analysis.

Neck pain is among the most prevalent musculoskeletal conditions worldwide. The underlying cause mostly remains unidentified, classified as non-specific neck pain. Pain can alter movement patterns and physiological responses, suggesting that certain biomechanical and physiological changes may serve as objective biomarkers for non-specific neck pain.

The Scottish inflammatory prognostic score: A novel biomarker for predicting in-hospital mortality in acute heart failure with reduced ejection fraction.

Background: Acute heart failure with reduced ejection fraction (AHF) remains a leading cause of ED visits, hospitalizations, and in-hospital mortality.

Objectives: To evaluate the prognostic utility of the Scottish Inflammatory Prognostic Score (SIPS) in patients with AHF.

Methods: This retrospective study analyzed 508 patients admitted with AHF between November 2022 and November 2024.

Entheseal structural damage according to OMERACT definitions unveils distinct ultrasound phenotypes in SpA: findings from the DEUS multicentre study.

Objectives: To explore the prevalence and distribution of ultrasound-detected lesions indicating structural damage at the enthesis (e.g., bone erosions, enthesophytes, and calcifications) in patients with spondyloarthritis (SpA), comparing those with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA), and to investigate the demographic, clinical, and metabolic factors linked to these lesions.

Prognostic immunotherapy score (PIS) in patients with advanced urothelial carcinoma treated with pembrolizumab: real-world data and validation from ARON-2 dataset.

Recent years have seen the development and advent of novel combinatorial strategies based on immunotherapy, and immune checkpoint inhibitor (ICI) - based treatment has established itself as a mainstay in the treatment of metastatic urothelial carcinoma (UC). Herein, we aimed to validate the prognostic value of a previously developed score, the Prognostic Immunotherapy Score (PIS), including female sex, Eastern Cooperative Oncology Group Performance Status (ECOG-PS) and liver metastases, in patients treated with pembrolizumab for advanced UC from the ARON-2 dataset. We retrospectively analyzed clinical data from Metastatic UC patients diagnosed at age ≥ 18 years.

Too vulnerable? Successful practices for conducting research with children and young people who have life-limiting or life-threatening illness.

Background: A dearth of evidence exists on how to include children and young people in palliative care research.

Aim: We aimed to identify successful practices in involvement, recruitment and data collection with children and young people with life-limiting illness in research.

Design: We synthesised methods from five primary studies from three geographical regions in which children with life-limiting conditions were recruited and interviewed.

Drawing and mutual storytelling to alleviate anxiety and improve emotional well-being in children in PICU: a randomized controlled trial.

Unlabelled: This parallel-group randomized controlled trial evaluated the effectiveness of drawing and mutual storytelling techniques in reducing anxiety and improving the emotional well-being of children aged 7-12 years in a pediatric intensive care unit (PICU). This study was conducted in a city hospital between August 2024 and January 2025, involving 70 children. Participants were randomly assigned to either an intervention group (n = 35) or a control group (n = 35).

Diagnostic performance of Ga-PSMA-11 PET/MRI in biochemical recurrent prostate cancer after radical prostatectomy and prediction nomogram.

Background: This study aimed to evaluate the diagnostic performance of Ga-PSMA-11 PET/MRI in prostate cancer (PC) with biochemical recurrence (BCR) after radical prostatectomy (RP). It was also aimed to develop a nomogram to predict PET/MRI positivity.

Methods: The data of 140 PC patients who underwent Ga-PSMA-11 PET/MRI for BCR after RP were retrospectively analyzed.

Evaluation of Amplification Systems for Sound Localization and Speech Perception in Single-Sided Deafness: A Comparative Study With Low-Frequency Stimulus.

Purpose: This study aimed to evaluate the impact of different hearing devices on sound localization and speech perception in individuals with single-sided deafness (SSD). Specifically, the study sought to assess the performance of softband bone-anchored hearing aids (BAHAs) and contralateral routing of signals hearing aids (CROS HA) in various conditions to determine their effectiveness in improving auditory outcomes for SSD patients.

Method: Eighteen participants (aged between 20 and 50 years) with SSD underwent tests using softband BAHA, CROS HA, and unaided conditions in a counterbalanced design.

Interatrial block predicts left atrial appendage thrombus in nonvalvular atrial fibrillation.

Background: Interatrial block (IAB) is an electrocardiographic manifestation of atrial conduction delay and structural remodeling. While it has been linked to atrial fibrillation (AF) and thromboembolic events, its potential role in predicting left atrial appendage (LAA) thrombus formation remains underexplored. This study aimed to investigate the association between IAB and the presence of LAA thrombus in patients with nonvalvular AF (NVAF) or atrial flutter referred for rhythm control procedures.

Sensorimotor Cortical Integration Remains Unchanged After Dorsal Root Ganglion Pulsed Radiofrequency.

Background: Dorsal root ganglion (DRG) pulsed radiofrequency (PRF) is a minimally invasive neuromodulation technique used for the management of chronic radicular pain. While its analgesic effects are well-documented, its impact on sensorimotor integration at the cortical level remains unclear. This study aimed to investigate whether DRG PRF modulates sensorimotor integration via the cholinergic system using the Short-Latency Afferent Inhibition (SAI) paradigm.

Comparison of tibial tubercle-Roman arch distance and tibial tubercle-trochlear groove distance in patients with patellar dislocation or subluxation.

Objective: To compare tibial tubercle-trochlear groove (TT-TG) and tibial tubercle-Roman arch (TT-RA) distances in patients with patellar dislocation or subluxation, evaluate TT-RA reliability and reproducibility, and determine pathological threshold values for surgical treatment using magnetic resonance imaging (MRI) and computed tomography (CT).

Materials And Methods: Retrospective analysis included 259 patient and 262 control examinations of knee MRIs and/or CTs performed. TT-RA, TT-TG, and tibial tubercle-posterior cruciate ligament (TT-PCL) distances, Roman Arch height, trochlear sulcus angle, and total femoral condyle width were measured by two radiologists, and trochlear morphology was assessed.

Management of Thoracolumbar Injury Classification and Severity Score (TLICS) 4 thoracolumbar fractures after natural disasters: Comparative outcomes of conservative and surgical treatments following the 2023 Türkiye earthquake.

Background: This study examines the outcomes of conservative versus surgical treatment for Thoracolumbar Injury Classification and Severity Score (TLICS) 4 thoracolumbar fractures in patients injured during the 2023 Türkiye earthquake. It aims to assess clinical and radiographic outcomes while considering the impact of crush syndrome-related complications on treatment decisions.

Methods: Twenty-three patients with TLICS 4 spinal injuries were evaluated and divided into surgical (n=12) and conservative (n=11) groups.

Pediatric burns in low-income countries: An example from Somalia.

Background: Epidemiological data are needed to develop pediatric burn prevention strategies and guide interventions in low-and middle-income countries.

Methods: In this observational retrospective study, the characteristics of 140 consecutive pediatric patients who were hospitalized and treated for burns at the Burns Unit of a hospital in Mogadishu, Somalia, between November 2022 and April 2024 were analyzed.

Results: The patients included 50% males and 50% females, with a mean age of 4.