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This review explores the century-long trajectory of gut microbiome research and its contribution to shaping our modern diet. It further highlights the transformative potential of current discoveries to revolutionize future dietary habits and nutritional practices. From the pioneering work of E. Metchnikoff in the early 20th century, which led to the widespread adoption of yoghurt in many Western countries, to the emergence of probiotics and prebiotics, the microbiota has become a key determinant in human health and nutrition. Current developments provide new perspectives on the future, such as next-generation probiotics and prebiotics, dietary recommendations adapted to the specific needs of the microbiota, and precision nutrition that considers individual microbiota variability.
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http://dx.doi.org/10.1016/j.tjnut.2025.08.032 | DOI Listing |
Helicobacter
September 2025
Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Background: Several clinical studies have demonstrated that Helicobacter pylori (Hp) infection may exacerbate the progression of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD); however, the underlying mechanisms remain unclear. This study aims to investigate the characterization of the gastric microbiome and metabolome in relation to the progression of MASLD induced by Hp infection.
Methods: We established a high-fat diet (HFD) obese mouse model, both with and without Hp infection, to compare alterations in serum and liver metabolic phenotypes.
Curr Microbiol
September 2025
Department of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
This review article describes recent research advances in the relationship between spinal cord injury (SCI) and the gut microbiota and each other's inflammatory response. SCI is a serious neurological disease that directly damages physiological function. Recent studies have shown that SCI significantly affected the composition and function of the gut microbiota, and even caused intestinal inflammation.
View Article and Find Full Text PDFPestic Biochem Physiol
November 2025
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, China. Electronic address:
Honey bee health is affected by a variety of environmental factors, with Varroa destructor parasitism and pesticide exposure being important factors contributing to colony decline. In this study, we assessed the effects of V. destructor infestation in combination with imidacloprid exposure on honey bees.
View Article and Find Full Text PDFPestic Biochem Physiol
November 2025
College of Resources and Environment, Northeast Agricultural University, Harbin 150030, Heilongjiang, PR China. Electronic address:
Fomesafen (FSA), a diphenyl ether herbicide, causes toxicity to non-target organisms and subsequent crops. Vermi-remediation is advocated as an effective remediation method, but there has been no research on the isolation and mechanism of FSA-degradation strains from earthworm gut. In this study, three ecotypes of earthworms- Eisenia foetida (epigeic), Metaphire guillelmi (anecic), and Aporrectodea caliginosa (endogenic), were used to investigate the degradation mechanism of FSA in soil-plant-earthworm systems for the first time.
View Article and Find Full Text PDFJ Steroid Biochem Mol Biol
September 2025
Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia. Electronic address:
Vitamin D has been proposed to attenuate chemotherapy-induced gastrointestinal mucositis (GM). In the intestine, local catabolism of active vitamin D [1,25-dihydroxyvitamin D₃] is mediated by the enzyme Cyp24a1. This study assessed whether deletion of Cyp24a1 specifically in intestinal epithelial cells can protect against 5-fluorouracil (5-FU)-induced intestinal injury and microbiome disruption in mice.
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