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Article Abstract
bark is used in Mexican traditional medicine to treat chronic illnesses, including diabetes. For this reason, the purpose of this work was to evaluate the anti-hyperglycaemic effect of the aqueous extract from bark. Therefore, the aqueous extract at 40 mg/kg, administered orally and chronically, exhibited an anti-hyperglycaemic effect in a streptozotocin/nicotinamide model in Wistar rats. Because of our chemical study of this species demonstrated the presence of the coumarins xanthyletin (), luvangetin (), 8-hydroxyxanthyletin (), and methoxyrutaretin (), we also determined the presence of this bioactive compounds in the aqueous infusion and their quantification therein by developing a new, simple, fast, selective, sensitive, and precise HPLC-DAD method according to ICH validation guideline. Finally, the presence of coumarins can be associated with the anti-hyperglycaemic effect shown by the extract.
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| http://dx.doi.org/10.1080/14786419.2025.2556456 | DOI Listing |
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