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http://dx.doi.org/10.1038/s41392-025-02406-5 | DOI Listing |
Neuropsychiatr Dis Treat
August 2025
Department of Psychiatry and Behavioral Sciences, New York Medical College, Valhalla, New York, USA.
Brexpiprazole is a second-generation antipsychotic with multiple indications, including the treatment of schizophrenia. As a partial dopamine agonist, brexpiprazole differs from most other antipsychotics, yet uncertainties about its full mechanism of action have led to some ambiguity among prescribers. To address this gap, an international panel of psychiatric experts was organized and convened with funding from Otsuka Pharmaceutical Europe Ltd and H.
View Article and Find Full Text PDFAlcohol Res
September 2025
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington.
Purpose: Alcohol use disorder (AUD) and mild traumatic brain injury (mTBI) have a bidirectional, synergistic, and complicated relationship. Although it is difficult to definitively say that mTBI causes AUD, certain biological mechanisms that occur after trauma are also associated with hazardous alcohol use. Hazardous drinking is defined as any quantity or pattern of alcohol consumption that places people at risk for physical and/or psychological harm.
View Article and Find Full Text PDFBiosens Bioelectron
September 2025
College of Life Sciences, China Jiliang University, Hangzhou, 310018, China. Electronic address:
Glucose sensors are critical analytical devices designed for precise and continuous monitoring of glucose concentrations, playing a pivotal role in healthcare, particularly in diabetes management. Here, we synthesis glucose oxidase (GOx)/Se hydrogel to detect the glucose, thereby generating measurable electrical signals. Further, the transfection of electronic signals rely on the poly(dopamine) (PDA) grid in hydrogel.
View Article and Find Full Text PDFMol Psychiatry
September 2025
Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Iron-the most abundant magnetic brain substance-is essential for many biological processes, including dopamine and myelin synthesis. Quantitative susceptibility mapping (QSM) MRI has recently linked altered subcortical magnetic susceptibility (χ) to schizophrenia. Since χ is increased by iron and decreased by myelin, abnormal levels of either could underlie these QSM differences.
View Article and Find Full Text PDFCarbohydr Polym
November 2025
Key Laboratory of Biomedical Polymers, Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, PR China. Electronic address:
Tissue adhesives have emerged as a promising alternative to conventional sutures and staplers in the management of hemostasis, tissue defect sealing, and wound repair. However, the efficacy of current bio-adhesives in clinical practice is compromised by the limitations, including poor wet adhesion, inadequate mechanical strength, vulnerability to gastrointestinal fluids, and insufficient hemostatic performance. Herein, a marine organism-inspired tough and adhesive patch (MOTAP) was developed to address these challenges.
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