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http://dx.doi.org/10.1016/j.jad.2025.120185 | DOI Listing |
Org Lett
September 2025
Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Halogenated phenazines hold promise as antimicrobial and antibiofilm agents, yet are mainly accessed via chemical synthesis. Herein, we report PezW, a novel single-component flavin-dependent halogenase (FDH) that halogenates phenazine scaffolds, notably enabling enzymatic synthesis of bioactive 2-bromo-1-hydroxyphenazine () and 2,4-bromo-1-hydroxyphenazine (). Structural modeling and mutagenesis revealed key residues critical for substrate binding and catalysis.
View Article and Find Full Text PDFHealth Expect
October 2025
Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Introduction: Despite high coverage of routine childhood vaccines, uptake of the human papillomavirus (HPV) vaccine in the Pacific Island nation of Tonga has been slow. Culturally appropriate communication resources on the importance, safety, and effectiveness of the HPV vaccine are critical to support acceptance and uptake. To develop these resources, it is important to understand what people want to know.
View Article and Find Full Text PDFCalcif Tissue Int
September 2025
Department of Endocrinology, Post-Graduate Institute of Medical Education and Research (PGIMER), 001, Nehru Extension Block, Chandigarh, India.
Rare diseases, defined by the 2002 Rare Disease Act, affect fewer than 5 in 10,000 individuals. Rare metabolic bone diseases (MBDs), such as osteogenesis imperfecta, hypophosphatasia, osteopetrosis, and other unclassified disorders, can disrupt bone development and remodeling, posing diagnostic and management challenges. This study analyzed data from the rarembd.
View Article and Find Full Text PDFEnviron Geochem Health
September 2025
Policy Research Center for Environment and Economy, Ministry of Ecology and Environment of the People's Republic of China, Beijing, 100101, China.
The behavior of polycyclic aromatic hydrocarbons (PAHs) released from tire road wear particles (TRWPs) in human digestive fluids may pose a significant risk to human health. However, the current understanding of the release pattern and influencing factors of PAHs from TRWPs is still insufficient. In this study, the release characteristics of PAHs from UV-aging TRWPs (ATRWPs) were systematically investigated by in vitro digestive simulation experiments, release kinetic model fitting and control variable experiments.
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