Use of MRI-double inversion recovery sequence for early diagnosis of multiple sclerosis: case series.

BMC Neurol

Department of Radiology, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Pudong New Area, Shanghai, 200120, China.

Published: August 2025


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

The choice of additional Double Inversion Recovery (DIR) Magnetic Resonance Imaging (MRI) sequences may affect the judgment of the presence and nature of lesions. Herein, we reported three cases initially presenting with non-typical multiple sclerosis (MS) symptoms, in which the final diagnosis of MS was confirmed after incorporating spinal cord and brain DIR MRI sequence. The sequence revealed more conspicuous lesions compared to conventional T2-weighted imaging or T2-weighted fluid-attenuated inversion recovery (T2WI/FLAIR) sequences. Consequently, the patients received an earlier definitive diagnosis and timely treatment. Our cases demonstrated the additional DIR sequences for the patients with non-typical MS symptoms were reasonable and may be helpful.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395631PMC
http://dx.doi.org/10.1186/s12883-025-04386-zDOI Listing

Publication Analysis

Top Keywords

inversion recovery
12
multiple sclerosis
8
mri-double inversion
4
recovery sequence
4
sequence early
4
early diagnosis
4
diagnosis multiple
4
sclerosis case
4
case series
4
series choice
4

Similar Publications

Unlabelled: Leptomeningeal metastasis (LM) is a severe complication of solid malignancies, including lung adenocarcinoma, characterized by poor prognosis and diagnostic challenges. This study assesses whether curvilinear peri-brainstem hyperintense signals on MRI are a characteristic feature of LM in lung adenocarcinoma patients.

Methods: This retrospective study analyzed data from multiple centers, encompassing lung adenocarcinoma patients with peri-brainstem curvilinear hyperintense signals on MRI between January 2016 and March 2022.

View Article and Find Full Text PDF

Parasagittal dural space and arachnoid granulations morphology in pre-clinical and early clinical multiple sclerosis.

Mult Scler

September 2025

Neuroimaging Unit, Neuroimmunology Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Neurology, VA Medical Center, TN Valley Healthcare System, Nashville, TN, USA.

Background: There is limited knowledge on the post-glymphatic structures such as the parasagittal dural (PSD) space and the arachnoid granulations (AGs) in multiple sclerosis (MS).

Objectives: To evaluate differences in volume and macromolecular content of PSD and AG between people with newly diagnosed MS (pwMS), clinically isolated syndrome (pwCIS), or radiologically isolated syndrome (pwRIS) and healthy controls (HCs) and their associations with clinical and radiological disease measures.

Methods: A total of 69 pwMS, pwCIS, pwRIS, and HCs underwent a 3.

View Article and Find Full Text PDF

Purpose: Gadoxetic acid-enhanced hepatobiliary phase T-weighted (Tw) MRI is effective for the detection of focal liver lesions but lacks sufficient T contrast to distinguish benign from malignant lesions. Although the addition of T, diffusion, and dynamic contrast-enhanced Tw imaging improves lesion characterization, these methods often do not provide adequate spatial resolution to identify subcentimeter lesions. This work proposes a high-resolution, volumetric, free-breathing liver MRI method that produces colocalized fat-suppressed, variable Tw images from a single acquisition, thereby improving both lesion detection and characterization.

View Article and Find Full Text PDF

Comparative clinical efficacy of nickel-titanium shape memory staples versus miniplate for Bartoníček-Rammelt type III and IV posterior malleolar fractures. A retrospective analysis of 47 consecutive patients treated between January 2022 and June 2024 documented operative time, intraoperative blood loss, fluoroscopy times, healing time, complications, postoperative fracture gap distance (mm), and articular surface step-off (mm) at the ankle joint. Ankle function was assessed using the American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot score, the Manchester-Oxford Foot Questionnaire (MOXFQ), and range of motion measurements at 3, 6, 12, and 14 months.

View Article and Find Full Text PDF

Positron Emission Tomography (PET) is a critical imaging modality in nuclear medicine but requires radioactive tracer administration, which increases radiation exposure risks. While recent studies have investigated MR-guided low-dose PET denoising, they neglect two critical factors: the synergistic roles of multicontrast MR images and disease-specific denoising requirements. In this work, we propose a diffusion model that integrates T1-weighted, T2 fluid attenuated inversion recovery (T2 FLAIR), and hippocampal-optimized (T2 HIPPO) MR sequences to achieve ultra-low-dose PET denoising tailored for temporal lobe epilepsy (TLE).

View Article and Find Full Text PDF