Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background And Aims: The only previous sequence report of measles virus from the Republic of the Congo (RoC) dates back to samples collected in 2000. To update the molecular epidemiology of measles virus in the RoC, our study genotyped measles virus strains circulating in the country from January 2023 to May 2024.
Methods: A total of 584 serum or plasma samples were collected by the National Laboratory of Public Health through its nationwide measles surveillance activities. Among these 584 suspected cases, 231 were IgM seropositive, and 170 of them were selected for molecular detection based on their collection date.
Results: Of these, 20 cases were RT-qPCR positive, and six sequences were suitable for sequence analysis. Phylogenetic analysis confirmed that the detected measles virus belongs to genotype B3, which is one of the two genotypes currently circulating globally, alongside genotype D8. Genetic comparison revealed three closely related variants, suggesting either ongoing endemic transmission or potential importation. Notably, 45% of PCR-positive samples had received two vaccine doses, highlighting the need for robust vaccine efficacy evaluation.
Conclusion: This study emphasizes the critical role of measles virus surveillance, genotyping capacities, and genetic characterization to strengthen regional disease monitoring and containment strategies.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379835 | PMC |
| http://dx.doi.org/10.1002/hsr2.71201 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Challenging 21-day quarantine guidelines for mumps in Beijing: Data-driven recommendations for a high-coverage MMR vaccination era (2019-2024).
Hum Vaccin Immunother
December 2025
Department of Planned Immunization, Chaoyang District Centre for Disease Control and Prevention, Beijing, China.
Mumps is a vaccine-preventable disease. Following Beijing's implementation of a three-dose MMR vaccination strategy, incidence rates declined significantly. However, the current 21-d quarantine period lacks evidence-based support, resulting in low compliance and conflicts between healthcare providers and patients.
View Article and Find Full Text PDF[Evaluation of changes in serum measles antibody levels in children with tumors before and after chemotherapy and the necessity of revaccination with measles-containing vaccines].
Zhonghua Yi Xue Za Zhi
September 2025
Department of Expanded Program on Immunization, Hangzhou Center for Diseases Control and Prevention (Hangzhou Health Supervision Institution), Hangzhou 310021, China.
To dynamically monitor the changes in measles antibody levels in children with tumors pre-and post-chemotherapy, and to evaluate the necessity of revaccination with measles-containing vaccines post-chemotherapy A prospective cohort study was conducted. Children with tumors under 15 years old who were hospitalized in the Children's Hospital, Zhejiang University School of Medicine from January 2022 to December 2023 were included as the case group; healthy children of the same age from the community during the same period were included as the control group. Blood samples were collected from the case group before chemotherapy and at 1 month and 6 months after chemotherapy, as well as from the control group.
View Article and Find Full Text PDFImpact of vaccination strategy adjustments on antibody levels against measles, rubella, mumps, and varicella in China: a single-center serological survey.
Front Immunol
September 2025
Department of Expanded Program on Immunization, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu, China.
Objective: This study evaluated trends in population immunity against measles, rubella, mumps, and varicella in Suqian City (2005-2024) using serological surveys (2019-2024) and incidence data, incorporating participants with known/unknown vaccination statuses to explore immunity dynamics amid evolving policies, and inform public health planning.
Methods: Serum samples from 541 (2019) and 506 (2024) healthy participants were analyzed for virus-specific IgG antibodies using ELISA. Disease incidence data were obtained from China's National Notifiable Disease Reporting System.
A Case of Measles Virus-caused Subacute Sclerosing Panencephalitis Diagnosed by Molecular and Clinical Analysis.
Open Forum Infect Dis
August 2025
Paediatric Intensive Care Unit, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Subacute sclerosing panencephalitis (SSPE) is a rare and lethal neurodegenerative encephalitis caused by persistent measles virus infection. We report an SSPE case in a patient infected at 6 months old, diagnosed using clinical methods and metagenomic sequencing, highlighting the benefits of combining clinical and molecular techniques for improved diagnosis.
View Article and Find Full Text PDFRecombinant live attenuated measles virus-based vaccines inducing comprehensive protection against Ebola and Marburg viruses.
Mol Ther
August 2025
Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230022, China; Department of Laboratory Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230036, China; Key Labora
Filoviruses, including Ebola and Marburg viruses, present significant global health challenges due to their high mortality rates. Despite the availability of several Ebola virus vaccines, none provide cross-protection against multiple filovirus species. In this study, we developed recombinant live attenuated measles virus-based vaccine candidates designed to express Ebola or Marburg virus glycoproteins and generate virus-like particles for pan-filovirus immunization.
View Article and Find Full Text PDF