[Evaluation of changes in serum measles antibody levels in children with tumors before and after chemotherapy and the necessity of revaccination with measles-containing vaccines].

To dynamically monitor the changes in measles antibody levels in children with tumors pre-and post-chemotherapy, and to evaluate the necessity of revaccination with measles-containing vaccines post-chemotherapy A prospective cohort study was conducted. Children with tumors under 15 years old who were hospitalized in the Children's Hospital, Zhejiang University School of Medicine from January 2022 to December 2023 were included as the case group; healthy children of the same age from the community during the same period were included as the control group. Blood samples were collected from the case group before chemotherapy and at 1 month and 6 months after chemotherapy, as well as from the control group.

Heightened innate immunity may trigger chronic inflammation, fatigue and post-exertional malaise in ME/CFS.

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by unexplained fatigue, post-exertional malaise (PEM), and cognitive dysfunction. ME/CFS patients often report a prodrome consistent with infection. We present a multi-omics analysis based on plasma metabolomic and proteomic profiling, and immune responses to microbial stimulation, before and after exercise.

Serum TSP-1 is a useful biomarker in severity assessment and the diagnosis of osteoarthritis.

Objective: Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degradation. Thrombospondin-1 (TSP-1) is a secreted trimeric glycoprotein with multiple functions. It can bind to various cell-surface receptors and is downregulated in OA chondrocytes.

Association between female reproductive factors and new-onset pancreatic cancer risk: a prospective cohort study.

The link between female reproductive factors and pancreatic cancer risk is unclear. This study examined these associations in a large prospective cohort and explored potential modification by genetic susceptibility. We analyzed data from 196 563 women in the UK Biobank using multivariable Cox proportional hazards models.

Decoding adenomyosis pathogenesis using an assembloid model.

Adenomyosis remains a challenging gynecological disorder to investigate due to the absence of in vitro models that accurately replicate endometrial tissue dynamics across the menstrual cycle. To address this gap, we established an endometrial assembloid model that faithfully mimics cycle-dependent endometrial responses and captures key cellular and molecular hallmarks of adenomyosis, including ectopic lesion- specific epithelial and stromal heterogeneity. Single-cell transcriptomics revealed that ectopic epithelial cells shift toward a luminal- dominant, glandular-deficient transcriptional profile during the secretory-like phase.