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In this paper, a novel 4H-SiC LDMOS structure with a trench heterojunction in the source (referred as to THD-LDMOS) is proposed and investigated for the first time, to enhance the reverse recovery performance of its parasitic diode. Compared with 4H-SiC, silicon has a smaller band energy, which results in a lower built-in potential for the junction formed by P+ polysilicon and a 4N-SiC N-drift region. A trench P+ polysilicon is introduced in the source side, forming a heterojunction with the N-drift region, and this heterojunction is unipolar and connected in parallel with the body PiN diode. When the LDMOS operates as a freewheeling diode, the trench heterojunction conducts first, preventing the parasitic PiN from turning on and thereby significantly reducing the number of carriers in the N-drift region. Consequently, THD-LDMOS exhibits superior reverse recovery characteristics. The simulation results indicate that the reverse recovery peak current and reverse recovery charge of THD-LDMOS are reduced by 55.5% and 77.6%, respectively, while the other basic electrical characteristics remains unaffected.
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http://dx.doi.org/10.3390/mi16080909 | DOI Listing |
Chem Biodivers
September 2025
School of Pharmaceutical Science, Yunnan Key Laboratory of Pharmacology for Natural Products/College of Modern Biomedical Industry, NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University, Kunming, P. R. China.
20(R)-ginsenoside Rg3 can reduce the effects of oxidative stress and cell death in cerebral ischemia‒reperfusion injury (CIRI). Neuroinflammation is crucial post-CIRI, but how 20(R)-Rg3 affects ischemia‒reperfusion-induced neuroinflammation is unclear. To study 20(R)-Rg3's effects on neuroinflammation and neuronal preservation in stroke models and explore toll-like receptor 4/myeloid differentiation factor-88/nuclear factor kappa B (TLR4/MyD88/NF-κB) pathway mechanisms.
View Article and Find Full Text PDFIntroduction Systemic inflammation alters lipid metabolism by suppressing hepatic lipoprotein synthesis, increasing catabolism, and impairing reverse cholesterol transport. These changes result in reduced levels of low-density lipoprotein (LDL), high-density lipoprotein (HDL), and total cholesterol (TC), despite elevated cardiovascular risk, which is a phenomenon termed the "inflammatory lipid paradox." While well-characterized in chronic inflammatory diseases, such as rheumatoid arthritis, its prevalence and clinical impact in hospitalized adults with systemic inflammation remain underexplored.
View Article and Find Full Text PDFJOR Spine
September 2025
Spine Center, Department of Orthopaedics Changzheng Hospital, Naval Medical University (Second Military Medical University) Shanghai People's Republic of China.
Background: Ossification of the posterior longitudinal ligament (OPLL) is a pathological condition characterized by ectopic ossification of spinal ligaments, primarily driven by abnormal osteogenic differentiation of ligament fibroblasts with stem cell-like properties. The SOX transcription factor family is crucial in regulating cell stemness and differentiation. Among them, SOX8 is known to influence osteoblast differentiation, but its role in OPLL remains unclear.
View Article and Find Full Text PDFBiochem Biophys Res Commun
August 2025
Intensive Care Unit, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, 430061, Hubei, China; Hubei Province Academy of Traditional Chinese Medicine, Wuhan, 430061, Hubei, China. Electronic address:
Background: Coxsackievirus B3 (CVB3) infection is a common cause of myocarditis, and the resulting inflammatory response and cellular damage can lead to severe cardiac dysfunction. Astragaloside IV (AS-IV), a natural compound with anti-inflammatory and antiviral properties, has shown potential therapeutic value in various inflammatory and immune-related diseases. Our study aims to explore the potential effects and underlying mechanisms of AS-IV in CVB3-induced viral myocarditis (VMC).
View Article and Find Full Text PDFAngew Chem Int Ed Engl
September 2025
Yunnan Key Laboratory of Non-ferrous Metals Vacuum Metallurgy, Kunming University of Science and Technology, Kunming, 650093, China.
To address palladium supply-demand challenges and conventional recovery inefficiencies, this study develops a lithium-mediated electrodeposition process for efficient palladium recycling from spent catalysts. Density functional theory calculations identified a controlled Pd→LiPd (Pd)→LiPdO (Pd) transformation pathway, and experimental verification confirmed that LiPd precursors underwent oxidative transformation into LiPdO with structural inheritance. LiPdO exhibited Pd-O coordination and underwent rapid dissolution in dilute hydrochloric acid.
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