Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Cardiac T-cell lymphoma is a rare and aggressive malignancy that often presents with nonspecific symptoms and is difficult to diagnose early.
Case Summary: A 73-year-old man presented with syncope, anorexia, and abdominal discomfort. During hospitalization, he developed hypereosinophilia and rapidly progressed to fulminant myocarditis. Despite steroid and immunoglobulin therapy, cardiac function declined, requiring extracorporeal membrane oxygenation and intra-aortic balloon pump support. Myocardial biopsy confirmed cardiac T-cell lymphoma with lymphocytic infiltration.
Discussion: Cardiac T-cell lymphoma with fulminant myocarditis is exceptionally rare and carries a poor prognosis. Diagnosis is often delayed because of vague symptoms. This case highlights the value of early myocardial biopsy and histopathologic evaluation in rapidly deteriorating cardiac function.
Take-home Messages: Early myocardial biopsy is crucial in cases of unexplained myocarditis with rapid deterioration. Cardiac T-cell lymphoma is a rare and aggressive condition that can rapidly progress to fulminant myocarditis in certain cases, necessitating early diagnosis and intervention.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371419 | PMC |
| http://dx.doi.org/10.1016/j.jaccas.2025.104743 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Single-Cell RNA Sequencing Reveals Granzyme K CD8 T Cells as a Target for Mitigating Plaque Instability Following Radiation.
J Am Heart Assoc
September 2025
Background: Cardiac issues following radiotherapy are increasingly prevalent among patients with thoracic cancer and coronary disease. However, the mechanisms underlying radiotherapy-induced plaque instability and changes in plaque characteristics on imaging remain unclear. This study used single-cell RNA sequencing to identify key features of vulnerable plaques following radiotherapy.
View Article and Find Full Text PDFObjective: To investigate the effects of carnosine on heart failure and to examine whether this is associated with reduced immunogenicity of oxidatively-generated aldehyde modified proteins.
Background: Heart failure is associated with the accumulation of lipid derived aldehydes that form immunogenic protein adducts. However, the pathological impact of these aldehydes and aldehyde-modified proteins in heart failure has not been assessed.
Resolving tumor microenvironment heterogeneity to forecast immunotherapy response in triple-negative breast cancer through multi-scale analysis.
Front Oncol
August 2025
Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Background: Immunotherapy has been used in the clinical management of TNBC. While BRCA1 mutations are associated with immunotherapy response, the therapeutic outcomes in TNBC patients are not promising.
Methods: This study integrated spatial, single-cell, and bulk RNA-seq data to explore the role of BRCA1 in reshaping the TNBC microenvironment.
Results in pediatric T-ALL patients treated in trial AIEOP-BFM ALL 2009: Prognostic factors in the context of modern risk-adapted therapy.
Hemasphere
September 2025
Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori Monza Italy.
To improve the outcome of pediatric T-cell acute lymphoblastic leukemia (T-ALL) patients, the AIEOP-BFM ALL 2009 trial modified T-ALL stratification and treatment based on AIEOP-BFM ALL 2000 and other pediatric ALL groups' results. This report aims to describe the outcome of T-ALL patients in trial AIEOP-BFM ALL 2009 and evaluate prognostic features defined within the end of induction (EOI) therapy, for future protocols stratification and interventions. From 06/2010 to 02/2017, 872 T-ALL patients, aged 1-17, were enrolled.
View Article and Find Full Text PDFElevated serum levels of monocyte chemoattractant protein-1 in 71 patients 3 months after elective cardiac surgery suggest a potential link to persistent inflammation but not an increased propensity for perioperative cerebrovascular events.
Front Med (Lausanne)
August 2025
Department of Anesthesiology and Perioperative Care, Mayo Clinic, Rochester, MN, United States.
Background: Monocyte chemoattractant protein 1 (MCP-1) plays a critical role in the transmigration of peripheral monocytes, a central mechanism underlying chronic inflammation. In this study, we investigate postoperative serum kinetics of MCP-1 as a potential contributor to postoperative neurocognitive decline, arteriosclerosis, and the development of organ failures.
Methods: Seventy-one patients undergoing elective cardiac surgery were included in this study.