Taurochenodeoxycholic acid as a sensitive stratification marker for HBV-associated hepatic cirrhosis status has a hepatoprotective effect.

Sci Rep

Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, 400016, China.

Published: August 2025


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The medicinal use of bile-derived materials dates back thousands of years. However, due to their complex origins and morphological similarities, adulteration of expensive bile types with cheaper alternatives remains prevalent in the market, significantly compromising quality control and regulatory oversight. To address this critical issue, this study employed ultra-high-performance liquid chromatography coupled with charged aerosol detection (UHPLC-CAD) technology combined with chemometric approaches, including chromatographic fingerprint similarity analysis, hierarchical cluster analysis, principal component analysis, and orthogonal partial least squares-discriminant analysis to systematically analyze 10 bile-derived medicinal materials: biotransformed bear bile powder, bear bile powder, pig bile powder, ox bile powder, sheep bile powder, chicken bile powder, duck bile powder, goose bile powder, rabbit bile powder, and snake bile powder.

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Taurochenodeoxycholic acid as a sensitive stratification marker for HBV-associated hepatic cirrhosis status has a hepatoprotective effect.

Sci Rep

August 2025

Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, 400016, China.

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Microbiome-metabolome generated bile acids gatekeep infliximab efficacy in Crohn's disease by licensing M1 suppression and Treg dominance.

J Adv Res

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The global rise in obesity necessitates new therapeutic strategies. This study, for the first time, elucidates a novel indirect mechanism for the metabolic benefits of fucoidan (SFF). We found that SFF administration to obese () mice, while showing no direct effect on adipocytes , led to a significant 6.

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