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Interest in gold nanoclusters (AuNCs) has grown significantly in recent decades. AuNCs, with a core size smaller than 2 nm, represent a unique class of functional nanomaterials. Their distinctive properties enable innovative applications across various interdisciplinary fields. Here, we introduce BioGoldNCDB, a freely available, fully annotated, and manually curated database of mainly about AuNCs and related AuNPs. Despite the rapid growth in biomedical applications of gold nanoclusters (AuNCs), the lack of a centralized and structured data resource hinders comparative analysis and rational design. Researchers face challenges in accessing standardized information on AuNCs' structures, properties, and biological activities, which limits data-driven development in this emerging field. The database provides essential information, including CAS numbers and PubMed IDs, as well as specific details such as biomedical applications, cell lines used in research, particle size, and excitation/emission wavelengths. It currently covers 247 articles from 104 journals. Designed with a user-friendly and intuitive web interface, BioGoldNCDB is accessible on multiple devices, including phones, tablets, and PCs. Users can refine searches with multiple filters, and a help page is available for guidance. While offering quick insights for newcomers, BioGoldNCDB also serves as a valuable resource for researchers across various fields.
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http://dx.doi.org/10.3390/molecules30153310 | DOI Listing |
Top Curr Chem (Cham)
September 2025
Center for Advanced Materials Research, Research Institute of Sciences and Engineering, University of Sharjah, 27272, Sharjah, United Arab Emirates.
Controlling the size of gold nanoparticles (AuNPs) has been critical in diagnostics, biomolecular sensing, targeted therapy, wastewater treatment, catalysis, and sensing applications. Ultrasmall AuNPs (uAuNPs), with sizes Ranging from 2 to 5 nm, and gold nanoclusters (AuNCs), with sizes less than 2 nm, are often dealt with interchangeably in the literature, making it challenging to review them separately. Although they are grouped in our discussion, their chemical and physical properties differ significantly, partly due to their electronic properties.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
School of Biomedical Engineering, Shenzhen Key Laboratory for Nano-Biosensing Technology, Guangdong Key Laboratory of Biomedical Measurements and Ultrasound Imaging, Marshall Laboratory of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, China.
Electrochemiluminescence (ECL) is rapidly emerging as an excellent electrochemical analytical technique for the specific and sensitive detection of various biomarkers and hazardous trace metals. Among ECL emitters, gold nanoclusters (AuNCs) have proven to be excellent luminophores due to their remarkable luminescent properties, stability, and biocompatibility. However, the low ECL efficiency of AuNCs precludes their application in ultrasensitive biosensing.
View Article and Find Full Text PDFJ Am Chem Soc
September 2025
Institutes of Physical Science and Information Technology, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui University, Hefei 230601, P. R. China.
Organic ligand-protected metal nanoclusters feature ultrasmall size, well-defined compositions, and diverse chiral structures. They have the potential to combine the advantages of asymmetric organocatalysis and nanometal catalysis. The major challenge is designing and synthesizing appropriate metal nanocluster structures for achieving high catalytic activity and excellent enantioselectivity.
View Article and Find Full Text PDFBioorg Chem
August 2025
ENT and Head and Neck Research Center and Department, The Five Senses Health Institute, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Radiation Oncology Department, Iran University of Medical Sciences, Tehran, Iran. Electronic address:
Recently, nanobubbles (NBs) have emerged as a groundbreaking platform for drug and gene delivery in the targeted treatment of cancer because of their unique advantages. The nanoscale dimensions, stability, and responsiveness to external triggers-for example, ultrasound-allow for highly selective localization and controlled release of therapeutic agents in tumor tissues. This review highlights the capability of NBs, when combined with ultrasound activation, to significantly improve the intracellular uptake, penetration, and therapeutic efficacy of chemotherapeutic agents, thus diminishing their off-target toxicity.
View Article and Find Full Text PDFTalanta
August 2025
College of Chemistry and Environmental Engineering, Institute for Advanced Study, School of Biomedical Engineering, Shenzhen University, Shenzhen, Guangdong, 518060, PR China. Electronic address:
17β-estradiol (E2) and estriol (E3), as natural estrogen contaminants in aquatic environments, have significant risks to ecosystems and human health by disrupting endocrine functions and inducing reproductive disorders even at trace levels. To address the urgent need for simultaneous monitoring of these structurally similar targets, we developed a dual-potential electrochemiluminescence (ECL) immunosensor for efficient parallel detection of E2 and E3. The sensor employs poly (1-naphthylamine)-molybdenum disulfide decorated with gold-silver bimetallic nanoclusters (PNA-MoS@AuAg NCs) as an ECL emitter, utilizing the self-enhancing property of AuAg NCs for intermolecular charge transfer and dual-potential-responsive properties to generate two well-resolved ECL signals (-0.
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