Publications by authors named "Ruo-Fan Liu"
Organic ligand-protected metal nanoclusters feature ultrasmall size, well-defined compositions, and diverse chiral structures. They have the potential to combine the advantages of asymmetric organocatalysis and nanometal catalysis. The major challenge is designing and synthesizing appropriate metal nanocluster structures for achieving high catalytic activity and excellent enantioselectivity.
View Article and Find Full Text PDFOral administration of astilbin mitigates acetaminophen-induced acute liver injury in mice by modulating the gut microbiota.
Acta Pharmacol Sin
February 2025
Article Synopsis
- Acetaminophen (APAP) overdose can lead to acute liver injury (ALI), and current treatments for this condition are limited; however, astilbin, a compound from Smilax glabra with antioxidant properties, shows promise in protecting against ALI.
- In a study with mice, astilbin was administered prior to APAP exposure, and the results indicated that it helped reduce ALI by altering gut microbiota and increasing beneficial metabolites like hydroxytyrosol.
- Further analysis revealed that hydroxytyrosol also provided protective effects by reducing oxidative stress and inflammation in the liver, demonstrating that astilbin promotes liver health through its interaction with gut microbes and metabolites.
[Low Intensity Anticoagulation Therapy for Chinese Population with Heart Valve Replacement--3 000 Cases Follow-up].
Sichuan Da Xue Xue Bao Yi Xue Ban
January 2016
Objective: To investigate the effect of low-intensity anticoagulation therapy for Chinese population with heart valve replacement.
Methods: From January 2011 to March 2012, 3 000 patients with heart valve replacement in Fuwai Hospital and West China Hospital were followed-up for 1 year, the method and intensity of postoperative anticoagulation, as well as the complications were studied and analyzed.
Results: The rate of follow-up was 88.