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Background: Chronic Insomnia Disorder (CID) significantly impairs both sleep quality and daytime functioning. However, current treatments have limited efficacy in improving daytime function and are often associated with side effects. This highlights the urgent need for effective and safe therapeutic approaches that can target both nocturnal and daytime symptoms.
Objective: To evaluate the clinical efficacy and safety of acupuncture in improving sleep quality and daytime functioning in patients with chronic insomnia, and to optimize its treatment protocol.
Methods: This study was a single-blind, randomised, controlled trial. The treatment group received acupuncture at HT7, BL15, LR3 and BL18, while the control group was treated at GV20, EX-HN22, BL62 and KI6. Each group underwent 10 sessions administered three times per week. The Insomnia Severity Index (ISI) served as the primary evaluation index for sleep efficacy, while the Pittsburgh Sleep Quality Index (PSQI) and polysomnography (PSG) were secondary indexes for sleep quality. The Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), Fatigue Severity Scale (FSS), and Epworth Sleepiness Scale (ESS) were used to evaluate daytime functional impairment.
Results: Totally 76 patients were included in this study and randomly assigned to the treatment group (n=38) and the control group (n=38). Both groups showed significant improvements in sleep quality and daytime functioning. The treatment group exhibited a mean ISI reduction of 7.58 points versus 5.71 points in the control group; however, this difference was not statistically significant. PSG data revealed similar improvements in total sleep time, sleep efficiency, and REM sleep percentage across groups. Notably, the treatment group demonstrated significantly greater reductions in BAI and BDI scores (p<0.05), while improvements in FSS and ESS scores were comparable.
Conclusion: Acupuncture is an effective and safe treatment to improve sleep as well as daytime functioning for chronic insomnia. The protocol using HT7, BL15, LR3 and BL18 may offer added benefits for reducing anxiety and depressive symptoms.
Clinical Trial Registration: This study was registered with the China Clinical Trial Registry (CCTR), registration ID: ChiCTR2200066102.
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http://dx.doi.org/10.2147/NSS.S521578 | DOI Listing |
Nat Sci Sleep
September 2025
Department of Ophthalmology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, People's Republic of China.
Objective: To investigate the prevalence of dry eye disease (DED) among children and adolescents aged 9 to 19 years in Fengyang County, and to explore the associations of sleep duration and social jetlag with DED, with the aim of providing scientific evidence for sleep-based interventions to prevent DED in this population.
Methods: Between November and December 2023, 14 primary and secondary schools were randomly selected in Fengyang County, Chuzhou City, Anhui Province, China. Students from Grade 4 to Grade 12 (aged 9-19 years) were invited to participate.
Front Nutr
August 2025
Department of Gastroenterology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, China.
Background: Dietary patterns influence psychological health, systemic inflammation, and gut microbiota composition in colon cancer patients. This study evaluates the associations of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) score and the Dietary Index for Gut Microbiota (DI-GM) with psychological outcomes, inflammatory markers, gut microbiota diversity (Shannon index) and composition (Firmicutes/Bacteroidetes ratio), and tumor biomarkers in colon cancer patients.
Methods: A cross-sectional study was conducted on 630 colon Cancer patients.
Front Allergy
August 2025
Department of Surgery, University of Auckland, Auckland, New Zealand.
Allergic rhinitis (AR) and chronic rhinosinusitis (CRS) are common respiratory conditions that significantly impact patient health and contribute to substantial healthcare burdens. While conventional treatments offer symptom relief, many patients continue to experience persistent symptoms, side effects, or resistance to standard therapies. This highlights the growing need for novel, non-invasive, and sustainable therapeutic strategies to manage chronic airway inflammation.
View Article and Find Full Text PDFJ Adolesc Res
September 2025
University of Southern California, Los Angeles, USA.
A community-based qualitative study identified multilevel influences on sleep duration, quality, and timing in 10 to 12-year-old Latino pre-adolescents via 11 focus groups with 46 children and 15 interviews with parents. An iterative content analysis revealed three themes negatively and positively impacted sleep: (1) Individual-level; (2) Social-level; and (3) Environmental-level influences. At the individual level, use of technology (e.
View Article and Find Full Text PDFCureus
August 2025
Pharmacology, Indira Gandhi Institute of Medical Sciences, Patna, IND.
Background Delirium and sleep disturbances are common in critically ill patients and are associated with adverse outcomes, including prolonged intensive care unit (ICU) stays. Ramelteon, a melatonin receptor agonist, may improve sleep and reduce delirium by regulating circadian rhythms. This study evaluated the efficacy of ramelteon in shortening ICU stay, decreasing delirium incidence and duration, and improving sleep quality in critically ill patients.
View Article and Find Full Text PDF