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Lung cancer (LC) is one of the leading causes of cancer related deaths worldwide and early recognition is critical for enhancing patient outcomes. However, existing LC detection techniques face challenges such as high computational demands, complex data integration, scalability limitations, and difficulties in achieving rigorous clinical validation. This research proposes an Enhanced Hyper Tuning Deep Learning (EHTDL) model utilizing bioinspired algorithms to overcome these limitations and improve accuracy and efficiency of LC detection and classification. The methodology begins with the Smooth Edge Enhancement (SEE) technique for preprocessing CT images, followed by feature extraction using GLCM-based Texture Analysis. To refine the features and reduce dimensionality, a Hybrid Feature Selection approach combining Grey Wolf optimization (GWO) and Differential Evolution (DE) is employed. Precise lung segmentation is performed using Mask R-CNN to ensure accurate delineation of lung regions. A Deep Fractal Edge Classifier (DFEC) is introduced, consisting of five fractal blocks with convolutional layers and pooling to progressively learn LC characteristics. The proposed EHTDL model achieves remarkable performance metrics, including 99% accuracy, 100% precision, 98% recall, and 99% 1-score, demonstrating its robustness and effectiveness. The model's scalability and efficiency make it suitable for real-time clinical application offering a promising solution for early LC detection and significantly enhancing patient care.
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http://dx.doi.org/10.1177/03913988251359522 | DOI Listing |
Adv Mater
September 2025
Center for Technology in Water and Wastewater, School of Civil and Environmental Engineering, University of Technology Sydney, Ultimo, NSW, 2007, Australia.
Global water scarcity demands next-generation desalination technologies that transcend the limitations of energy-intensive processes and salt accumulation. Herein, a groundbreaking interfacial solar steam generation system capable of simultaneous hypersaline desalination and ambient energy harvesting is introduced. Through hierarchical hydrogel architecture incorporating a central vertical channel and radial channels with gradient apertures, the design effectively decouples salt transport and water evaporation: solar-driven fluid convection directs water outward for evaporation, while inward salt migration prevents surface crystallization and redistributes excess heat.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Hebei Key Laboratory of Molecular Oncology, Tangshan, Hebei Province, China.
This retrospective study aims to evaluate the effectiveness of a simplified scoring model utilizing contrast-enhanced computed tomography (CECT) in distinguishing low-risk thymomas (LRTs) from thymic cysts in patients with anterior mediastinal hyper-attenuating nodules. A total of 32 patients of LRTs and 40 patients of hyper-attenuating thymic cysts who underwent chest biphasic CECT preoperatively from January 2015 to December 2022 were included. The traditional CT imaging features and clinical features of each patient were analyzed.
View Article and Find Full Text PDFMinerva Obstet Gynecol
September 2025
Brussels IVF, University Hospital of Brussels, Brussels, Belgium -
The management of assisted reproductive technology (ART) in predicted hyper-responders to ovarian stimulation represents a complex and challenging clinical scenario, whereby the benefits of higher oocyte yield must be balanced against the drawbacks and risks of ovarian hyperstimulation syndrome. This review explores advances in ART for hyper-responders, focusing on adapted stimulation protocols, ovulation triggering, cryopreservation, and personalized strategies to optimize outcomes. In-vitro maturation of oocytes, an emerging alternative, is gaining traction for increasing live birth rates in selected cases and expert centers.
View Article and Find Full Text PDFJ Neurosci
September 2025
Faculty of Psychology, Southwest University, Chongqing, China
While the hyper- and hypo- reward or punishment sensitivities (RS, PS) have received considerable attention as prominent transdiagnostic features of psychopathology, the lack of an overarching neurobiological characterization currently limits their early identification and neuromodulation. Here we combined microarray data from the Allen Human Brain Atlas with a multimodal fMRI approach to uncover the neurobiological signatures of RS and PS in a discovery-replication design (N=655 healthy participants, 442 Females). Both RS and PS were mapped separately in the brain, with the functional connectome in the fronto-striatal network encoding reward responsiveness, while the fronto-insular system was particularly engaged in punishment sensitivity.
View Article and Find Full Text PDFCommun Biol
September 2025
The Key Laboratory of Advanced Interdisciplinary Studies, School of Public healthy, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Adenosine-to-inosine (A-to-I) RNA editing is a critical post-transcriptional modification that enhances tumor genome diversity and contributes to cancer progression. In non-small cell lung cancer (NSCLC), while specific A-to-I editing events have been identified, their functional mechanisms and clinical relevance remain poorly understood. Here, through whole-transcriptome analysis of NSCLC specimens, we discovered a hyper-editing event at position c.
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