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This pilot study evaluates the effectiveness of MatriDerm (MedSkin Solutions Dr. Suwelack AG) as a dermal substitute in primary cleft palate surgery, especially for closure of lateral palatal gaps. The authors retrospectively studied 20 patients (mean age: 10 mo) who underwent unilateral or bilateral cleft palate repair at Al Jalila Children's Specialty Hospital from January 2022 to December 2024. Von-Langenbeck and Bardach's palatoplasty was performed, with MatriDerm (MedSkin Solutions Dr. Suwelack AG) applied inside lateral releasing incisions. Healing was assessed at 1 week and 2 weeks postoperatively. Over 50% epithelialization was observed at 1 week, and over 75% by 2 weeks, with no scarring or arch collapse. MatriDerm (MedSkin Solutions Dr. Suwelack AG) seems to enhance mucosal healing without causing any scarring, which can affect palatal integrity and the maxillary arch growth, making an insight to further long-term research.
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http://dx.doi.org/10.1097/SCS.0000000000011724 | DOI Listing |
Oral Dis
September 2025
Department of Oral Diagnosis, School of Dentistry, University of Campinas (FOP/UNICAMP), Piracicaba, Brazil.
Ann Epidemiol
September 2025
School of Public Health, Peking University, Beijing, China. Electronic address:
Purpose: We estimated the association between maternal sexually transmitted diseases (STDs) and the risk of specific birth defects among live singleton births in the United States (US).
Methods: We conducted a population-based study using data from birth certificates for 14,602,822 live singleton births occurring from 2016 to 2019 in the US. We used logistic regression to estimate the associations between three maternal STDs (chlamydia, gonorrhea, and syphilis) and the risk of four specific birth defects (gastroschisis, cleft lip with or without cleft palate, spina bifida, and hypospadias), adjusting for socio-demographic and pregnancy-related factors.
Ann Plast Surg
September 2025
Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN.
Background: The generation of intelligible speech is the single most important outcome after cleft palate repair. The development of velopharyngeal dysfunction (VPD) compromises the outcome, and the burden of VPD remains largely unknown in low- and middle-income countries (LMICs). To scale up VPD care in these areas, we continue to explore the use of artificial intelligence (AI) and machine learning (ML) for automatic detection of VPD from speech samples alone.
View Article and Find Full Text PDFJ Clin Res Pediatr Endocrinol
September 2025
İnönü University Faculty of Medicine, Department of Medical Genetics, Malatya, Türkiye.
CHARGE syndrome is an autosomal dominant disorder caused by variations in the CHD7 gene. The characteristic findings of the syndrome include coloboma (C), heart anomalies (H), choanal atresia (A), growth and developmental delay (R), genitourinary system anomalies (G), and ear anomalies and/or hearing loss (E). A 7.
View Article and Find Full Text PDFBackground: Numerous surgical approaches are useful to treat palatal fistulas secondary cleft palate deformities. Regional flaps have been described for secondary reconstruction of cleft palate, so the facial artery musculo mucosal (FAMM) flap and the buccinator myomucosal flap are examples. The aim of this study is to assess the complication rate of 2 different flaps for fistula repair.
View Article and Find Full Text PDF