Modeling mammalian hibernation to improve organ cold preservation: Using the intestine as an example.

Cell Res

GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, Guangdong, China.

Published: September 2025


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12408813PMC
http://dx.doi.org/10.1038/s41422-025-01149-wDOI Listing

Publication Analysis

Top Keywords

modeling mammalian
4
mammalian hibernation
4
hibernation improve
4
improve organ
4
organ cold
4
cold preservation
4
preservation intestine
4
intestine example
4
modeling
1
hibernation
1

Similar Publications

Background: Neighborhoods resulting from rapid urbanization processes are often saturated with eateries for local communities, potentially increasing exposure to unhealthy foods and creating diabetogenic residential habitats.

Objective: We examined the association between proximity of commercial food outlets to local neighborhood residences and type 2 diabetes (T2D) cases to explore how local T2D rates vary by location and provide policy-driven metrics to monitor food outlet density as a potential control for high local T2D rates.

Methods: This cross-sectional ecological study included 11,354 patients with active T2D aged ≥20 years geocoded using approximate neighborhood residence aggregated to area-level rates and counts by subdistricts (mukims) in Penang, northern Malaysia.

View Article and Find Full Text PDF

Background: Lesbian, gay, bisexual, transgender, queer/questioning, intersex, asexual (LGBTQIA+) researchers and participants frequently encounter hostility in virtual environments, particularly on social media platforms where public commentary on research advertisements can foster stigmatization. Despite a growing body of work on researcher virtual hostility, little empirical research has examined the actual content and emotional tone of public responses to LGBTQIA+-focused research recruitment.

Objective: This study aimed to analyze the thematic patterns and sentiment of social media comments directed at LGBTQIA+ research recruitment advertisements, in order to better understand how virtual stigma is communicated and how it may impact both researchers and potential participants.

View Article and Find Full Text PDF

Association Between In-Hospital Applications for Long-Term Care Services and Hospital Length of Stay Among Older Adults: Ecological Cross-Sectional Study.

JMIR Form Res

September 2025

Department of Health Economics, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Research Institute, Obu, Japan.

Background: Delayed discharge among older patients presents a major challenge for the efficiency of health service delivery. Prolonged hospitalizations limit bed turnover, increase costs, and reduce the availability of hospital resources. In Japan, older adults must undergo a formal care needs certification process to access public long-term care (LTC) services.

View Article and Find Full Text PDF

Background: Primary liver cancer, particularly hepatocellular carcinoma (HCC), poses significant clinical challenges due to late-stage diagnosis, tumor heterogeneity, and rapidly evolving therapeutic strategies. While systematic reviews and meta-analyses are essential for updating clinical guidelines, their labor-intensive nature limits timely evidence synthesis.

Objective: This study proposes an automated literature screening workflow powered by large language models (LLMs) to accelerate evidence synthesis for HCC treatment guidelines.

View Article and Find Full Text PDF

Background: Sleep duration plays a crucial role in cognitive health and is closely linked to cognitive decline. However, the relationship between sleep duration and cognitive function in the Chinese population remains poorly understood.

Objective: This study aims to evaluate the association between sleep duration and cognitive function among middle-aged and older adults in China.

View Article and Find Full Text PDF