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http://dx.doi.org/10.1055/a-2646-1724 | DOI Listing |
ESC Heart Fail
September 2025
Department of Cardiac-, Thoracic-, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.
Aims: Non-pharmacological therapies for acute decompensated heart failure (HF) and cardiogenic shock have evolved considerably in recent decades. Short-term mechanical circulatory support (MCS) devices can be used as circulatory backup. While nearly all available devices use continuous flow, evidence indicates that pulsatile flow can be more effective.
View Article and Find Full Text PDFNeuropsychopharmacology
September 2025
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Severe worry is a transdiagnostic, highly prevalent symptom, difficult to treat and associated with significant morbidity in late life. Understanding the neural correlates of worry induction and reappraisal in older adults is key to developing novel treatments. We recruited 124 older adults ( ≥ 50 years old) with varying worry severity and clinical comorbidity (27% generalized anxiety disorder, 23% depressive disorders).
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
September 2025
Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology. Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, People's Republic of China.
Purpose: Evidence on the association between visceral obesity and diabetic retinopathy (DR) remains sparse and debatable. We aimed to use three novel indicators, body roundness index (BRI), lipid accumulation product (LAP), and visceral adiposity index (VAI), to investigate the longitudinal relationship between visceral obesity and DR, and explore the potential metabolic mechanisms.
Methods: In this prospective study based on the UK Biobank (UKB), 14,738 individuals with diabetes free of DR at baseline were included.
ACS Omega
September 2025
Materials and Manufacturing Directorate, AFRL/RXEE, Air Force Research Laboratory, Wright-Patterson AFB, Ohio 45433, United States.
This study addresses a critical limitation in direct bonded copper (DBC) materials used in power electronics by introducing a copper-zirconium (Cu/Zr) alloy interposing layer at the copper-ceramic interface. This novel design aims to mitigate mechanical stress induced by mismatched material properties, such as the coefficient of thermal expansion (CTE) and elastic modulus, during thermal cycling. The key findings of this study are (1) thermal fatigue improvement: Test samples with the Cu/Zr interface layer (Cu-Cu/Zr-AlN) three times enhanced thermal fatigue resistance, surviving 30 thermal cycles from -55 to 300 °C before delamination, while standard DBC substrates without the Cu/Zr layer failed after just 10 cycles, indicating a performance improvement with the Cu/Zr alloy, (2) durability projections: Based on the Coffin-Manson model, if the upper temperature is capped at 150 °C, the Cu-Cu/Zr-AlN substrates are projected to survive approximately 1372 cycles, underscoring their potential for long-term reliability, and (3) stress mitigation: The Cu/Zr alloy layer bridges the CTE disparity between copper and ceramic, reducing mechanical stress and improving structural integrity across a broad temperature range (-55 to 300 °C).
View Article and Find Full Text PDFUltrasonics
September 2025
Paderborn University, Paderborn, Germany.
This study investigates the phenomenon of mode repulsion in Lamb waves propagating through two coupled plates with an elastic interface. Using a spring-based coupling model and the Scaled Boundary Finite Element Method, the dispersion curves of the coupled system are analyzed under various interface conditions-weak coupling, sliding boundary, and perfect coupling. This research highlights how the mechanical stiffness of the interface influences the separation of modes and the emergence of repulsion regions.
View Article and Find Full Text PDF