,-Disubstituted Anilines Synthesis through Smiles Rearrangement.

J Org Chem

Department of Pharmaceutical Technology (Process Chemistry), National Institute of Pharmaceutical Education and Research, S. A. S. Nagar, Punjab 160062, India.

Published: August 2025


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Article Abstract

Herein, we report a general and mild approach to effectively synthesize N-substituted anilines under metal-free conditions using sulfonyl chlorides and amines. Notably, this approach has shown a wide array of functional group tolerance, operational simplicity, and scalability, making it a useful tool for accessing ,-disubstituted anilines and functionalized products.

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http://dx.doi.org/10.1021/acs.joc.5c01125DOI Listing

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