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http://dx.doi.org/10.1016/j.jdcr.2025.05.004 | DOI Listing |
J Cereb Blood Flow Metab
September 2025
Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Functional PET (fPET) identifies stimulation-specific changes of physiological processes, individual molecular connectivity and group-level molecular covariance. Since there is currently no consistent analysis approach available for these techniques, we present a toolbox for unified fPET assessment. The toolbox supports analysis of data obtained with a variety of radiotracers, scanners, experimental protocols, cognitive tasks and species.
View Article and Find Full Text PDFACS Nano
September 2025
School of Microelectronics, Hefei University of Technology, Hefei 230009, China.
Near-infrared (NIR) narrowband photodetectors, featuring high sensitivity, excellent wavelength selectivity, and narrow full width at half-maximum (fwhm), enable efficient detection of specific NIR wavelengths and are widely used in optical communication, environmental monitoring, spectroscopy, and scientific research. In this study, we present a self-powered NIR photodetector based on a silicon nanowire (SiNW) array, exhibiting an ultranarrowband response centered at 1120 nm. The device employs a simple Schottky junction architecture.
View Article and Find Full Text PDFAnal Chim Acta
November 2025
Department of Chemical Engineering and Analytical Chemistry, Institute for Research on Nutrition and Food Safety (INSA·UB), University of Barcelona, Spain. Electronic address:
Background: Targeted bottom-up proteomics is of great interest for the straightforward, accurate, and sensitive measurement of specific protein biomarkers from surrogate peptide fragments. However, this approach typically relies on off-line enzymatic digestion with trypsin, a time-consuming step that may be inadequate for covering certain sequence regions containing important post-translational modifications (PTMs).
Results: In this study, we present an in-line enzymatic digestion strategy for the targeted bottom-up analysis of α-synuclein (α-syn), which is a protein biomarker of Parkinson's disease (PD).
Anal Chim Acta
November 2025
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, 266109, China. Electronic address:
Background: The separation of structural isomers is always a challenging task for liquid chromatography because of their similar physicochemical property. Research has found that materials with regular microporous structures exhibit excellent isomer separation performance. However, as the most easily available chromatographic material, silica stationary phases with regular and small mesopore structure have not yet been prepared, and it remains to be confirmed whether narrow pores in silica materials have the enhancing effect on shape selectivity in the separation of structural isomers.
View Article and Find Full Text PDFAnal Chim Acta
November 2025
NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine, Hainan Medical University, Haikou, Hainan, 571199, China. Electronic address:
Background: While paper-based colorimetric assays have seen significant progress in recent years, persistent challenges including the coffee-ring effect and infiltration effect continue to affect the color uniformity of detection results, leading to decreased sensitivity and accuracy of the detection. Recent advancements in suppressing these two effects mainly depend on chemical modification of cellulose fibers or application of specific functional coatings. However, the former's complex procedures impede large-scale implementation, while the latter's non-cellulosic additives risk unpredictable interactions with analytes or interference in colorimetric reactions.
View Article and Find Full Text PDF