Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Parkinson's disease (PD) pathogenesis involves dopaminergic neuron loss, yet the role of long non-coding RNAs (lncRNAs) remains poorly characterized. In this study, we perform a comprehensive meta-analysis of PD transcriptomes, identifying the top 50 significantly dysregulated lncRNAs (25 upregulated including NEAT1 and LINC00869; 25 downregulated including CASC2 and HULC) from 718 differentially expressed lncRNAs. Through functional enrichment analyses, we demonstrate that upregulated lncRNAs predominantly regulate neuroinflammatory pathways (NEAT1-NF-κB), α-synuclein aggregation (HOTAIR), regulation of gene expression epigenetic (MEG3) and vesicle trafficking (LINC00869), while downregulated lncRNAs control apoptotic signaling (CASC2-MAPK), lysosomal function (SFTA3), and metabolic homeostasis (HULC). Additionally, the KEGG pathway analysis convergence of ATXN8OS with spinocerebellar ataxia pathways further highlighted shared mechanisms of neurodegeneration. Notably, lncRNA-protein interaction network analysis of PD-associated lncRNAs identified two distinct interactomes: (1) an upregulated module (10 hubs/50 proteins/360 edges) enriched for neuroinflammation (NEAT1-centric), and (2) a downregulated module (8 hubs/190 proteins/1,282 edges) dominated by apoptotic regulation (CASC2-centric). These findings provide a systemic proof that lncRNAs networks may serve as diagnostic biomarkers and therapeutic targets.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.brainres.2025.149838 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Molecular subtypes of human skeletal muscle in cancer cachexia.
Nature
September 2025
Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Cancer-associated muscle wasting is associated with poor clinical outcomes, but its underlying biology is largely uncharted in humans. Unbiased analysis of the RNAome (coding and non-coding RNAs) with unsupervised clustering using integrative non-negative matrix factorization provides a means of identifying distinct molecular subtypes and was applied here to muscle of patients with colorectal or pancreatic cancer. Rectus abdominis biopsies from 84 patients were profiled using high-throughput next-generation sequencing.
View Article and Find Full Text PDFAuthor Correction: Lnc-mg is a long non-coding RNA that promotes myogenesis.
Nat Commun
September 2025
Guangdong Provincial Key Laboratory of Bioengineering Medicine & National Engineering Research Center of Genetic Medicine, Department of Cell Biology and Institute of Biomedicine, Jinan University, Huang-Pu Avenue West 601, Guangzhou, 510632, China.
Complex interplay of transcriptomic alterations, inflammatory cascades, and oxidative stress responses in a rat model of neonatal hypoxic-ischemic encephalopathy.
Gene
September 2025
Institute of Physiology, Medical School, University of Pécs H-7624 Pécs, Hungary. Electronic address:
In this edition of Gene's "Editor's Corner" we summarize the complex interactions of different molecular mechanisms behind the pathogenesis of neonatal hypoxic-ischemic encephalopathy (HIE). The topic is relevant, as the therapeutic options for HIE are limited, it is important to have as much knowledge as possible about the molecular processes underlying the disease. In the recent issue of Gene (Gene 952, 2025, 149363), Wang et al.
View Article and Find Full Text PDFThe KAP1 chromatin regulator and Paupar long non-coding RNA control subventricular zone neural stem cell maintenance and neurogenesis.
Stem Cell Reports
September 2025
Department of Physiology, Anatomy and Genetics, University of Oxford, OX1 3PT Oxford, UK. Electronic address:
Neural stem cells (NSCs) in the subventricular zone (SVZ) produce neurons throughout life. However, the epigenetic mechanisms that maintain NSCs and control neurogenesis remain unclear. We previously showed the long non-coding RNA (lncRNA) Paupar and KAP1 transcription co-factor control neuroblastoma cell growth.
View Article and Find Full Text PDFMechanistic roles of long non-coding RNAs in DNA damage response and genome stability.
Mutat Res Rev Mutat Res
September 2025
Institute of Environmental Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China. Electronic address:
To maintain genomic stability, cells have evolved complex mechanisms collectively known as the DNA damage response (DDR), which includes DNA repair, cell cycle checkpoints, apoptosis, and gene expression regulation. Recent studies have revealed that long non-coding RNAs (lncRNAs) are pivotal regulators of the DDR. Beyond their established roles in recruiting repair proteins and modulating gene expression, emerging evidence highlights two particularly intriguing functions.
View Article and Find Full Text PDF