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Article Abstract
Bovine viral diarrhea virus (BVDV) causes bovine viral diarrhea-mucosal disease that is characterized by diarrhea, fever, leukopenia, and propagation disorders in host animals. Autophagy acts an important regulatory role during virial infection. However, the molecular mechanisms that BVDV induces autophagy remain poorly defined. Here, we report that BVDV non-structural protein 4B (NS4B) promotes autophagy in MDBK cells and HEK-293T cells by reducing the level of p62 protein and increasing the production of LC3-II protein, and NS4B proteins were able to improve autophagy in MDBK cells by inhibiting the phosphorylation of mTOR protein. In addition, NS4B (90-260aa) acts a main role in promoting autophagy. The results reveal a new mechanism of BVDV to induce autophagy in host cells and also provide a new theoretical basis for the interaction between BVDV and host cells, and an important target for the prevention and control of BVDV.
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| http://dx.doi.org/10.1016/j.vetimm.2025.110973 | DOI Listing |
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