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Determination of hip muscle paths and their moment arms is crucial in subject-specific musculoskeletal modeling. Existing approaches, including via-point, obstacle-set, and others, cannot estimate a smooth path for biarticular muscles such as iliopsoas. This study proposed a modified convex wrapping algorithm based on subject-specific medical imaging to prevent the predicted path from penetrating its underlying bone geometries. Muscle attachment points were automatically personalized using the point cloud registration method. The muscle path was then defined as the shortest path wrapped over the convex hull and searched via Dijkstra's algorithm. Moreover, a constraint plane for preventing muscle-bone penetration was obtained using the point cloud of the underlying bone. The results of the identified iliopsoas path were compared with the conventional via-point method, revealing that the proposed algorithm can overcome the shortcoming of path non-smoothness via-point paths with certain hip postures. The obtained moment arms were further validated using the magnetic-resonance-imaging-based measurement from the literature, corroborating its applications in musculoskeletal modeling and quantitative surgical planning.
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http://dx.doi.org/10.1016/j.jbiomech.2025.112802 | DOI Listing |
JB JS Open Access
September 2025
Department of Orthopaedic Surgery, Mass General Brigham, Harvard Medical School, Boston, Massachusetts.
Background: It is unclear whether the current North Atlantic Treaty Organization (NATO) trauma system will be effective in the setting of Large-Scale Combat Operations (LSCO). We sought to model the efficacy of the NATO trauma system in the setting of LSCO. We also intended to model novel scenarios that could better adapt the current system to LSCO.
View Article and Find Full Text PDFFront Vet Sci
August 2025
Department of Musculoskeletal Biology and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom.
Body composition metrics such as bodyweight, body condition score (BCS) and muscle condition score (MCS) can be readily recorded as part of veterinary examinations in ageing cats. However, the description of how these parameters change with age, whilst accounting for sex and age-related morbidity, is limited. The aim of this prospective cohort study was to evaluate age, sex and health-related changes in bodyweight, BCS and MCS in client-owned pet cats.
View Article and Find Full Text PDFClin J Pain
September 2025
Department of Clinical Psychological Science, University of Maastricht, the Netherlands.
Objectives: Although the multifactorial nature of chronic pain is well established, research has predominantly examined isolated variables or singular pathways that may contribute to this condition. We use a complex systems perspective to examine the interplay of psychological factors in the context of chronic pain.
Methods: We analyzed two cross-sectional datasets (N=935 and 1366) collected at a pain clinic and rehabilitation center in Belgium from individuals primarily with musculoskeletal pain.
Acta Pharmacol Sin
September 2025
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Chemotherapeutic resistance is a significant issue in the treatment of breast cancer, which is related to pyroptosis inhibition. Increasing evidence suggests that long non-coding RNAs (lncRNAs) contribute to tumorigenesis and drug resistance. In this study we investigated the role of the lncRNA STMN1P2 in doxorubicin resistance in breast cancer, as well as its correlation with pyroptosis inhibition.
View Article and Find Full Text PDFIntroduction: Frailty, characterized by a reduction in intrinsic capacity across multiple physiological systems, is a key concern in healthy aging. Insight in the trajectory of an individual's functional ability and intrinsic reserve capacity in a relatively younger population of older adults is lacking. This study aims to investigate the early stages of frailty by tracking trajectories of physical indicators of intrinsic capacity before frailty becomes clinically evident.
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