Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Background: Schwann cells are responsible for producing the myelin sheath that surrounds the axons in the peripheral nervous system. Benign tumors that originate from Schwann cells are called schwannomas or neurilemmomas. These tumors typically present as slow-growing, solitary, encapsulated masses, often associated with nerve trunks. Schwannomas are relatively rare, with 25-45% of cases occurring in the head and neck region.

Case Presentation: This report aims to describe the presentations, work-up, and treatment of a 38-year-old Indian female patient with head and neck schwannoma in an atypical location. It was an incidental swelling noted during functional endoscopic sinus surgery. The tumor was found to be originating from the junction of the posterior and lateral pharyngeal wall near the lower edge of the torus tubarius on the left side. Complete surgical excision of the tumor was done in this case with no reported recurrence at 6 months' follow-up. The final diagnosis was made on the basis of histopathology and immunohistochemistry findings.

Conclusion: Histopathology should serve as the foundation for a definitive diagnosis. Tumor removal can be carried out using minimally invasive surgery through the endoscopic approach, resulting in fewer complications and a lowered risk of morbidity.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181876PMC
http://dx.doi.org/10.1186/s13256-025-05132-2DOI Listing

Publication Analysis

Top Keywords

schwann cells
8
head neck
8
diagnosis management
4
management unusual
4
unusual presentation
4
presentation schwannoma
4
schwannoma nasopharynx
4
nasopharynx case
4
case report
4
report background
4

Similar Publications

Vitamin D Binding Protein, a Ligand of Integrin beta 1, Motivates Both Tumor Cells and Schwann Cells to Promote Perineural Invasion in Pancreatic Ductal Adenocarcinoma.

Adv Sci (Weinh)

September 2025

State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.

Perineural invasion (PNI) is a common pathological characteristic of pancreatic ductal adenocarcinoma (PDAC), closely linked to postoperative recurrence, metastasis, and unfavorable prognosis. Nevertheless, the precise mechanisms that govern PNI in PDAC remain poorly elucidated. Here, group-specific component protein (GC) is identified as one of the most significantly upregulated genes related to PNI, primarily derived from malignant ductal cells compared to other cell types.

View Article and Find Full Text PDF

Painful diabetic neuropathy (PDN), a severe microvascular complication of diabetes, is closely associated with neuroinflammation. This study aimed to investigate the mechanism of circ_0002590 in neuroinflammation associated with PDN.The Schwann cells (HEI193) were treated with high glucose (HG, 150 mM) to simulate the diabetic microenvironment.

View Article and Find Full Text PDF

Background: Imeglimin (Ime), the first in a novel class of antidiabetic agents, has potential therapeutic effects on diabetic peripheral neuropathy (DPN). This study aimed to evaluate and compare the effects on cellular metabolic function and reactive oxygen species (ROS) levels in high glucose-treated mouse Schwann cells (SCs), an DPN model, with those of metformin (Met), a conventional antidiabetic agent known for its beneficial effects on DPN. The roles of PPARα and fatty acid-binding proteins 5 and 7 (FABP5 and FABP7), both of which have been implicated in the pathogenesis of DPN, were also investigated.

View Article and Find Full Text PDF

Senescence-regulating agents remodel mesenchymal stem cell-schwann cell circuitry for diabetic bone regeneration.

Biomaterials

August 2025

Department of Oral and Cranio-maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laborator

Bone healing requires Schwann cells (SCs) paracrine factors for mesenchymal stem cell function. Diabetes mellitus (DM) patients are susceptible to developing SCs dysfunction and impairing bone healing. Rare research considered reconstructing mesenchymal stem cell-schwann cell circuitry in diabetic bone regeneration.

View Article and Find Full Text PDF

Reduced mitochondrial quality and quantity in tumors is associated with dedifferentiation and increased malignancy. However, it remains unclear how to restore mitochondrial quantity and quality in tumors and whether mitochondrial restoration can drive tumor differentiation. Our study shows that restoring mitochondrial function using retinoic acid (RA) to boost mitochondrial biogenesis and a mitochondrial uncoupler to enhance respiration synergistically drives neuroblastoma differentiation and inhibits proliferation.

View Article and Find Full Text PDF